Short term synaptic depression imposes a frequency dependent filter on synaptic information transfer.

Depletion of synaptic neurotransmitter vesicles induces a form of short term depression in synapses throughout the nervous system. This plasticity affects how synapses filter presynaptic spike trains. The filtering properties of short term depression are often studied using a deterministic synapse m...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Robert Rosenbaum, Jonathan Rubin, Brent Doiron
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Acceso en línea:https://doaj.org/article/27513d8901d640a5adabfd9427a9f9dc
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:27513d8901d640a5adabfd9427a9f9dc
record_format dspace
spelling oai:doaj.org-article:27513d8901d640a5adabfd9427a9f9dc2021-11-18T05:51:14ZShort term synaptic depression imposes a frequency dependent filter on synaptic information transfer.1553-734X1553-735810.1371/journal.pcbi.1002557https://doaj.org/article/27513d8901d640a5adabfd9427a9f9dc2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22737062/pdf/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Depletion of synaptic neurotransmitter vesicles induces a form of short term depression in synapses throughout the nervous system. This plasticity affects how synapses filter presynaptic spike trains. The filtering properties of short term depression are often studied using a deterministic synapse model that predicts the mean synaptic response to a presynaptic spike train, but ignores variability introduced by the probabilistic nature of vesicle release and stochasticity in synaptic recovery time. We show that this additional variability has important consequences for the synaptic filtering of presynaptic information. In particular, a synapse model with stochastic vesicle dynamics suppresses information encoded at lower frequencies more than information encoded at higher frequencies, while a model that ignores this stochasticity transfers information encoded at any frequency equally well. This distinction between the two models persists even when large numbers of synaptic contacts are considered. Our study provides strong evidence that the stochastic nature neurotransmitter vesicle dynamics must be considered when analyzing the information flow across a synapse.Robert RosenbaumJonathan RubinBrent DoironPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 8, Iss 6, p e1002557 (2012)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Robert Rosenbaum
Jonathan Rubin
Brent Doiron
Short term synaptic depression imposes a frequency dependent filter on synaptic information transfer.
description Depletion of synaptic neurotransmitter vesicles induces a form of short term depression in synapses throughout the nervous system. This plasticity affects how synapses filter presynaptic spike trains. The filtering properties of short term depression are often studied using a deterministic synapse model that predicts the mean synaptic response to a presynaptic spike train, but ignores variability introduced by the probabilistic nature of vesicle release and stochasticity in synaptic recovery time. We show that this additional variability has important consequences for the synaptic filtering of presynaptic information. In particular, a synapse model with stochastic vesicle dynamics suppresses information encoded at lower frequencies more than information encoded at higher frequencies, while a model that ignores this stochasticity transfers information encoded at any frequency equally well. This distinction between the two models persists even when large numbers of synaptic contacts are considered. Our study provides strong evidence that the stochastic nature neurotransmitter vesicle dynamics must be considered when analyzing the information flow across a synapse.
format article
author Robert Rosenbaum
Jonathan Rubin
Brent Doiron
author_facet Robert Rosenbaum
Jonathan Rubin
Brent Doiron
author_sort Robert Rosenbaum
title Short term synaptic depression imposes a frequency dependent filter on synaptic information transfer.
title_short Short term synaptic depression imposes a frequency dependent filter on synaptic information transfer.
title_full Short term synaptic depression imposes a frequency dependent filter on synaptic information transfer.
title_fullStr Short term synaptic depression imposes a frequency dependent filter on synaptic information transfer.
title_full_unstemmed Short term synaptic depression imposes a frequency dependent filter on synaptic information transfer.
title_sort short term synaptic depression imposes a frequency dependent filter on synaptic information transfer.
publisher Public Library of Science (PLoS)
publishDate 2012
url https://doaj.org/article/27513d8901d640a5adabfd9427a9f9dc
work_keys_str_mv AT robertrosenbaum shorttermsynapticdepressionimposesafrequencydependentfilteronsynapticinformationtransfer
AT jonathanrubin shorttermsynapticdepressionimposesafrequencydependentfilteronsynapticinformationtransfer
AT brentdoiron shorttermsynapticdepressionimposesafrequencydependentfilteronsynapticinformationtransfer
_version_ 1718424715884756992