Centrosomal-associated Proteins: Potential therapeutic targets for solid tumors?

The centrosome is a special organelle in human cells and an organizing unit for microtubules and signaling molecules. In addition, the centrosome is tightly restricted during the cell cycle and forms the basal body of the cilia in ciliated cells. Centrosome abnormality is frequently observed in mali...

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Autores principales:	Yi Luan, Mingli Li, Yi Zhao, Qianqian Li, Jia Wen, Siqi Gao, Yang Yang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Centrosome Cancer Structure Centrosomal-associated Proteins Therapeutic targets Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/27523eb27725425d821e938d6a49a361
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spelling	oai:doaj.org-article:27523eb27725425d821e938d6a49a3612021-11-14T04:29:18ZCentrosomal-associated Proteins: Potential therapeutic targets for solid tumors?0753-332210.1016/j.biopha.2021.112292https://doaj.org/article/27523eb27725425d821e938d6a49a3612021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221010763https://doaj.org/toc/0753-3322The centrosome is a special organelle in human cells and an organizing unit for microtubules and signaling molecules. In addition, the centrosome is tightly restricted during the cell cycle and forms the basal body of the cilia in ciliated cells. Centrosome abnormality is frequently observed in malignant tumors. The dysregulation of centrosome-associated proteins leads to multipolar mitosis, aneuploidy, and nondirected cell migration, and therefore promotes cancer progression. The overduplication of primary centrosome and the accumulation of chromosome, comprise the majority cause of chromosomal mis-segregation in cancer cells. This review discusses the structure and function of the centrosome and the role of its associated proteins in the progression of solid tumors. We summarized the effects of centrosome amplification abnormalities and other centrosome-related phenotypes on tumors. The mechanism of the delineation of centrosome amplification with tumor malignancy remains to be decided. A better understanding of centrosome abnormality in tumorigenesis may be useful to screen novel therapeutic strategies for the treatment of solid tumors.Yi LuanMingli LiYi ZhaoQianqian LiJia WenSiqi GaoYang YangElsevierarticleCentrosomeCancerStructureCentrosomal-associated ProteinsTherapeutic targetsTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112292- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Centrosome Cancer Structure Centrosomal-associated Proteins Therapeutic targets Therapeutics. Pharmacology RM1-950
spellingShingle	Centrosome Cancer Structure Centrosomal-associated Proteins Therapeutic targets Therapeutics. Pharmacology RM1-950 Yi Luan Mingli Li Yi Zhao Qianqian Li Jia Wen Siqi Gao Yang Yang Centrosomal-associated Proteins: Potential therapeutic targets for solid tumors?
description	The centrosome is a special organelle in human cells and an organizing unit for microtubules and signaling molecules. In addition, the centrosome is tightly restricted during the cell cycle and forms the basal body of the cilia in ciliated cells. Centrosome abnormality is frequently observed in malignant tumors. The dysregulation of centrosome-associated proteins leads to multipolar mitosis, aneuploidy, and nondirected cell migration, and therefore promotes cancer progression. The overduplication of primary centrosome and the accumulation of chromosome, comprise the majority cause of chromosomal mis-segregation in cancer cells. This review discusses the structure and function of the centrosome and the role of its associated proteins in the progression of solid tumors. We summarized the effects of centrosome amplification abnormalities and other centrosome-related phenotypes on tumors. The mechanism of the delineation of centrosome amplification with tumor malignancy remains to be decided. A better understanding of centrosome abnormality in tumorigenesis may be useful to screen novel therapeutic strategies for the treatment of solid tumors.
format	article
author	Yi Luan Mingli Li Yi Zhao Qianqian Li Jia Wen Siqi Gao Yang Yang
author_facet	Yi Luan Mingli Li Yi Zhao Qianqian Li Jia Wen Siqi Gao Yang Yang
author_sort	Yi Luan
title	Centrosomal-associated Proteins: Potential therapeutic targets for solid tumors?
title_short	Centrosomal-associated Proteins: Potential therapeutic targets for solid tumors?
title_full	Centrosomal-associated Proteins: Potential therapeutic targets for solid tumors?
title_fullStr	Centrosomal-associated Proteins: Potential therapeutic targets for solid tumors?
title_full_unstemmed	Centrosomal-associated Proteins: Potential therapeutic targets for solid tumors?
title_sort	centrosomal-associated proteins: potential therapeutic targets for solid tumors?
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/27523eb27725425d821e938d6a49a361
work_keys_str_mv	AT yiluan centrosomalassociatedproteinspotentialtherapeutictargetsforsolidtumors AT minglili centrosomalassociatedproteinspotentialtherapeutictargetsforsolidtumors AT yizhao centrosomalassociatedproteinspotentialtherapeutictargetsforsolidtumors AT qianqianli centrosomalassociatedproteinspotentialtherapeutictargetsforsolidtumors AT jiawen centrosomalassociatedproteinspotentialtherapeutictargetsforsolidtumors AT siqigao centrosomalassociatedproteinspotentialtherapeutictargetsforsolidtumors AT yangyang centrosomalassociatedproteinspotentialtherapeutictargetsforsolidtumors
_version_	1718430005743058944

Centrosomal-associated Proteins: Potential therapeutic targets for solid tumors?

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