Understanding the Relationship Between the Neurologic Pupil Index and Constriction Velocity Values

Abstract The pupillary light reflex (PLR) describes the response when light hits the retina and sends a signal (cranial nerve II) to the Edinger-Westphal Nucleus which via cranial nerve III results in pupillary constriction. The Neurological Pupil indexTM (NPi) and pupil constriction velocity (CV) a...

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Autores principales:	Ifeoluwa Shoyombo, Venkatesh Aiyagari, Sonja E. Stutzman, Folefac Atem, Michelle Hill, Stephen A. Figueroa, Chad Miller, Amber Howard, DaiWai M. Olson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/27536cc104fb478abb59c310ae91e394
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spelling	oai:doaj.org-article:27536cc104fb478abb59c310ae91e3942021-12-02T12:33:00ZUnderstanding the Relationship Between the Neurologic Pupil Index and Constriction Velocity Values10.1038/s41598-018-25477-72045-2322https://doaj.org/article/27536cc104fb478abb59c310ae91e3942018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25477-7https://doaj.org/toc/2045-2322Abstract The pupillary light reflex (PLR) describes the response when light hits the retina and sends a signal (cranial nerve II) to the Edinger-Westphal Nucleus which via cranial nerve III results in pupillary constriction. The Neurological Pupil indexTM (NPi) and pupil constriction velocity (CV) are two distinct variables that can be observed and measured using a pupillometer. We examine NPi and CV in 27,462 pupil readings (1,617 subjects). NPi values <3.0 and a CV < 0.8 mm/sec were considered abnormal. Regression was used to clarify the effect of pupil size and repeated measures. An odds ratio of abnormal CV given normal NPi (and vice versa) was computed using the glimmixed (SAS) regression. Of 27,462 readings, 49.2% revealed bilaterally normal NPi wtih brisk CV, and 10.8% revealed bilaterally abnormal NPi and slow CV; 9.1% with unilaterally normal NPi and brisk CV where the opposite pupil had an abnormal NPi and slow CV. The remaining 30.9% revealed that one or both PLR had either a normal NPi with slow CV, or abnormal NPi with brisk CV. Brisk CV does not rule out an abnormal PLR; slow CV does not rule in abnormal PLR. Practitioners should consider these implications when interpreting pupillometry readings.Ifeoluwa ShoyomboVenkatesh AiyagariSonja E. StutzmanFolefac AtemMichelle HillStephen A. FigueroaChad MillerAmber HowardDaiWai M. OlsonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-6 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ifeoluwa Shoyombo Venkatesh Aiyagari Sonja E. Stutzman Folefac Atem Michelle Hill Stephen A. Figueroa Chad Miller Amber Howard DaiWai M. Olson Understanding the Relationship Between the Neurologic Pupil Index and Constriction Velocity Values
description	Abstract The pupillary light reflex (PLR) describes the response when light hits the retina and sends a signal (cranial nerve II) to the Edinger-Westphal Nucleus which via cranial nerve III results in pupillary constriction. The Neurological Pupil indexTM (NPi) and pupil constriction velocity (CV) are two distinct variables that can be observed and measured using a pupillometer. We examine NPi and CV in 27,462 pupil readings (1,617 subjects). NPi values <3.0 and a CV < 0.8 mm/sec were considered abnormal. Regression was used to clarify the effect of pupil size and repeated measures. An odds ratio of abnormal CV given normal NPi (and vice versa) was computed using the glimmixed (SAS) regression. Of 27,462 readings, 49.2% revealed bilaterally normal NPi wtih brisk CV, and 10.8% revealed bilaterally abnormal NPi and slow CV; 9.1% with unilaterally normal NPi and brisk CV where the opposite pupil had an abnormal NPi and slow CV. The remaining 30.9% revealed that one or both PLR had either a normal NPi with slow CV, or abnormal NPi with brisk CV. Brisk CV does not rule out an abnormal PLR; slow CV does not rule in abnormal PLR. Practitioners should consider these implications when interpreting pupillometry readings.
format	article
author	Ifeoluwa Shoyombo Venkatesh Aiyagari Sonja E. Stutzman Folefac Atem Michelle Hill Stephen A. Figueroa Chad Miller Amber Howard DaiWai M. Olson
author_facet	Ifeoluwa Shoyombo Venkatesh Aiyagari Sonja E. Stutzman Folefac Atem Michelle Hill Stephen A. Figueroa Chad Miller Amber Howard DaiWai M. Olson
author_sort	Ifeoluwa Shoyombo
title	Understanding the Relationship Between the Neurologic Pupil Index and Constriction Velocity Values
title_short	Understanding the Relationship Between the Neurologic Pupil Index and Constriction Velocity Values
title_full	Understanding the Relationship Between the Neurologic Pupil Index and Constriction Velocity Values
title_fullStr	Understanding the Relationship Between the Neurologic Pupil Index and Constriction Velocity Values
title_full_unstemmed	Understanding the Relationship Between the Neurologic Pupil Index and Constriction Velocity Values
title_sort	understanding the relationship between the neurologic pupil index and constriction velocity values
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/27536cc104fb478abb59c310ae91e394
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Understanding the Relationship Between the Neurologic Pupil Index and Constriction Velocity Values

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