The interaction of Ag2O nanoparticles with Escherichia coli: inhibition–sterilization process

Abstract Silver-based antibacterial agents have obtained wide attention due to the fact that bacteria in the environment is ubiquitous, which has become one of the most difficult problems for human health. However, the antibacterial mechanism and process are still inconclusive. Here, Ag2O nanopartic...

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Autores principales: Danqing Li, Shuai Chen, Ke Zhang, Nan Gao, Miao Zhang, Gadah Albasher, Jiangfan Shi, Chuanyi Wang
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/2755392b696e4b1b9596e9b3c6f607f1
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spelling oai:doaj.org-article:2755392b696e4b1b9596e9b3c6f607f12021-12-02T10:49:34ZThe interaction of Ag2O nanoparticles with Escherichia coli: inhibition–sterilization process10.1038/s41598-021-81305-52045-2322https://doaj.org/article/2755392b696e4b1b9596e9b3c6f607f12021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81305-5https://doaj.org/toc/2045-2322Abstract Silver-based antibacterial agents have obtained wide attention due to the fact that bacteria in the environment is ubiquitous, which has become one of the most difficult problems for human health. However, the antibacterial mechanism and process are still inconclusive. Here, Ag2O nanoparticles (NPs) with uniform spherical morphology and small size (around 30 nm) were prepared. The as-prepared Ag2O NPs induced high antibacterial activity (100% inhibition ratio) against E. coli. A two-step antibacterial process was proposed and confirmed, which divided into inhibition and sterilization steps. The optical density measurement, malondialdehyde concentration detection, morphologic imaging with electronic microscopy and Fourier transform infrared spectroscopic analysis unveiled the interaction of Ag2O NPs with E. coli, which verified the inhibition–sterilization process we proposed.Danqing LiShuai ChenKe ZhangNan GaoMiao ZhangGadah AlbasherJiangfan ShiChuanyi WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Danqing Li
Shuai Chen
Ke Zhang
Nan Gao
Miao Zhang
Gadah Albasher
Jiangfan Shi
Chuanyi Wang
The interaction of Ag2O nanoparticles with Escherichia coli: inhibition–sterilization process
description Abstract Silver-based antibacterial agents have obtained wide attention due to the fact that bacteria in the environment is ubiquitous, which has become one of the most difficult problems for human health. However, the antibacterial mechanism and process are still inconclusive. Here, Ag2O nanoparticles (NPs) with uniform spherical morphology and small size (around 30 nm) were prepared. The as-prepared Ag2O NPs induced high antibacterial activity (100% inhibition ratio) against E. coli. A two-step antibacterial process was proposed and confirmed, which divided into inhibition and sterilization steps. The optical density measurement, malondialdehyde concentration detection, morphologic imaging with electronic microscopy and Fourier transform infrared spectroscopic analysis unveiled the interaction of Ag2O NPs with E. coli, which verified the inhibition–sterilization process we proposed.
format article
author Danqing Li
Shuai Chen
Ke Zhang
Nan Gao
Miao Zhang
Gadah Albasher
Jiangfan Shi
Chuanyi Wang
author_facet Danqing Li
Shuai Chen
Ke Zhang
Nan Gao
Miao Zhang
Gadah Albasher
Jiangfan Shi
Chuanyi Wang
author_sort Danqing Li
title The interaction of Ag2O nanoparticles with Escherichia coli: inhibition–sterilization process
title_short The interaction of Ag2O nanoparticles with Escherichia coli: inhibition–sterilization process
title_full The interaction of Ag2O nanoparticles with Escherichia coli: inhibition–sterilization process
title_fullStr The interaction of Ag2O nanoparticles with Escherichia coli: inhibition–sterilization process
title_full_unstemmed The interaction of Ag2O nanoparticles with Escherichia coli: inhibition–sterilization process
title_sort interaction of ag2o nanoparticles with escherichia coli: inhibition–sterilization process
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/2755392b696e4b1b9596e9b3c6f607f1
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