JNK Activation Turns on LPS- and Gram-Negative Bacteria-Induced NADPH Oxidase-Dependent Suicidal NETosis

Abstract Neutrophils cast neutrophil extracellular traps (NETs) to ensnare microbial pathogens. Nevertheless, the molecular rheostats that regulate NETosis in response to bacteria are not clearly established. We hypothesized that stress-activated protein kinase or c-Jun N-terminal Kinase (SAPK/JNK)...

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Auteurs principaux: Meraj A. Khan, Armin Farahvash, David N. Douda, Johann-Christoph Licht, Hartmut Grasemann, Neil Sweezey, Nades Palaniyar
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Accès en ligne:https://doaj.org/article/2755d4df15b743fba2daff2f45656a21
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