Dynamics of changes and relationship between nitric oxide gasotransmitter and ribonucleasis indicators in patients with severe traumatic brain injury

Aim. To investigate the relationship between nitric oxide gasotransmitter and acid, alkaline ribonucleases enzymes in patients with severe traumatic brain injury and to determine the dynamics of peculiarities in case of their changes during the course of treatment. Material and Methods. The study...

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Autores principales:	V. Shevaha, A. Payenok, N. Matolinets, A. Netliukh, B. Zadorozhna, O. Kobyletskyy, T. Gutor
Formato:	article
Lenguaje:	EN UK
Publicado:	Danylo Halytsky Lviv National Medical University 2019
Materias:	traumatic brain injury, nitric oxide, ribonuclease, death, treatment consequences Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/27560cd8581241e285cd9f075d0cc891
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spelling	oai:doaj.org-article:27560cd8581241e285cd9f075d0cc8912021-11-10T19:49:51ZDynamics of changes and relationship between nitric oxide gasotransmitter and ribonucleasis indicators in patients with severe traumatic brain injury1029-42442415-330310.25040/aml2019.02.004https://doaj.org/article/27560cd8581241e285cd9f075d0cc8912019-09-01T00:00:00Zhttps://amljournal.com/index.php/journal/article/view/55https://doaj.org/toc/1029-4244https://doaj.org/toc/2415-3303Aim. To investigate the relationship between nitric oxide gasotransmitter and acid, alkaline ribonucleases enzymes in patients with severe traumatic brain injury and to determine the dynamics of peculiarities in case of their changes during the course of treatment. Material and Methods. The study investigated diagnostic data and treatment outcomes of 72 patients with severe traumatic brain injury aged 18-76 years (mean age 42.26±15.02 years), grouped into four groups by the Glasgow Outcome Scale: "Death", "Significant disability ","Moderate disability ", "Recovery". Results and Discussion. A significant growth of nitric oxide indicatorwas observed in patients with adverse effects (subsequently died or remained disabled) and it decreased over time to treat patient groups with relatively favorable treatment outcomes (moderate disability and recovery). The diagnostic markers of further adverse effects on life at the start of treatment (first day) include the level of urinary nitric oxide below 1.1 µmol/l and the level of RNase less than 25 IU/ml respectively. The direct correlation relationship between the value of nitric oxide level and RNase level on the 1st, 3rd, 7th and 9th (p<0.05) days of treatment has been proved. Conclusions. The results of the study would be important for the prompt assessment of the patient's condition and decision making regarding the treatment methods, minimizing the effect of the injury and predicting probable consequences of traumatic brain injury.V. ShevahaA. PayenokN. MatolinetsA. NetliukhB. ZadorozhnaO. KobyletskyyT. GutorDanylo Halytsky Lviv National Medical Universityarticletraumatic brain injury, nitric oxide, ribonuclease, death, treatment consequencesMedicine (General)R5-920ENUKActa Medica Leopoliensia, Vol 25, Iss 2-3, Pp 4-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN UK
topic	traumatic brain injury, nitric oxide, ribonuclease, death, treatment consequences Medicine (General) R5-920
spellingShingle	traumatic brain injury, nitric oxide, ribonuclease, death, treatment consequences Medicine (General) R5-920 V. Shevaha A. Payenok N. Matolinets A. Netliukh B. Zadorozhna O. Kobyletskyy T. Gutor Dynamics of changes and relationship between nitric oxide gasotransmitter and ribonucleasis indicators in patients with severe traumatic brain injury
description	Aim. To investigate the relationship between nitric oxide gasotransmitter and acid, alkaline ribonucleases enzymes in patients with severe traumatic brain injury and to determine the dynamics of peculiarities in case of their changes during the course of treatment. Material and Methods. The study investigated diagnostic data and treatment outcomes of 72 patients with severe traumatic brain injury aged 18-76 years (mean age 42.26±15.02 years), grouped into four groups by the Glasgow Outcome Scale: "Death", "Significant disability ","Moderate disability ", "Recovery". Results and Discussion. A significant growth of nitric oxide indicatorwas observed in patients with adverse effects (subsequently died or remained disabled) and it decreased over time to treat patient groups with relatively favorable treatment outcomes (moderate disability and recovery). The diagnostic markers of further adverse effects on life at the start of treatment (first day) include the level of urinary nitric oxide below 1.1 µmol/l and the level of RNase less than 25 IU/ml respectively. The direct correlation relationship between the value of nitric oxide level and RNase level on the 1st, 3rd, 7th and 9th (p<0.05) days of treatment has been proved. Conclusions. The results of the study would be important for the prompt assessment of the patient's condition and decision making regarding the treatment methods, minimizing the effect of the injury and predicting probable consequences of traumatic brain injury.
format	article
author	V. Shevaha A. Payenok N. Matolinets A. Netliukh B. Zadorozhna O. Kobyletskyy T. Gutor
author_facet	V. Shevaha A. Payenok N. Matolinets A. Netliukh B. Zadorozhna O. Kobyletskyy T. Gutor
author_sort	V. Shevaha
title	Dynamics of changes and relationship between nitric oxide gasotransmitter and ribonucleasis indicators in patients with severe traumatic brain injury
title_short	Dynamics of changes and relationship between nitric oxide gasotransmitter and ribonucleasis indicators in patients with severe traumatic brain injury
title_full	Dynamics of changes and relationship between nitric oxide gasotransmitter and ribonucleasis indicators in patients with severe traumatic brain injury
title_fullStr	Dynamics of changes and relationship between nitric oxide gasotransmitter and ribonucleasis indicators in patients with severe traumatic brain injury
title_full_unstemmed	Dynamics of changes and relationship between nitric oxide gasotransmitter and ribonucleasis indicators in patients with severe traumatic brain injury
title_sort	dynamics of changes and relationship between nitric oxide gasotransmitter and ribonucleasis indicators in patients with severe traumatic brain injury
publisher	Danylo Halytsky Lviv National Medical University
publishDate	2019
url	https://doaj.org/article/27560cd8581241e285cd9f075d0cc891
work_keys_str_mv	AT vshevaha dynamicsofchangesandrelationshipbetweennitricoxidegasotransmitterandribonucleasisindicatorsinpatientswithseveretraumaticbraininjury AT apayenok dynamicsofchangesandrelationshipbetweennitricoxidegasotransmitterandribonucleasisindicatorsinpatientswithseveretraumaticbraininjury AT nmatolinets dynamicsofchangesandrelationshipbetweennitricoxidegasotransmitterandribonucleasisindicatorsinpatientswithseveretraumaticbraininjury AT anetliukh dynamicsofchangesandrelationshipbetweennitricoxidegasotransmitterandribonucleasisindicatorsinpatientswithseveretraumaticbraininjury AT bzadorozhna dynamicsofchangesandrelationshipbetweennitricoxidegasotransmitterandribonucleasisindicatorsinpatientswithseveretraumaticbraininjury AT okobyletskyy dynamicsofchangesandrelationshipbetweennitricoxidegasotransmitterandribonucleasisindicatorsinpatientswithseveretraumaticbraininjury AT tgutor dynamicsofchangesandrelationshipbetweennitricoxidegasotransmitterandribonucleasisindicatorsinpatientswithseveretraumaticbraininjury
_version_	1718439760132833280

Dynamics of changes and relationship between nitric oxide gasotransmitter and ribonucleasis indicators in patients with severe traumatic brain injury

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