Fluoxetine Potentiates Phagocytosis and Autophagy in Microglia

Fluoxetine is a classic antidepressant drug, and its immunomodulatory effects have recently been reported in many disease models. In addition, it has strong antineuroinflammatory effects in stroke and neurodegenerative animal models. However, the effect of fluoxetine on microglia phagocytosis and it...

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Autores principales:	Sung Hee Park, Young-Sun Lee, Hyun-Jeong Yang, Gyun Jee Song
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	fluoxetine microglia phagocytosis autophagy neuroinflammation Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/275886f91cb34c54afc63941b6fec0bb
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spelling	oai:doaj.org-article:275886f91cb34c54afc63941b6fec0bb2021-12-01T08:33:42ZFluoxetine Potentiates Phagocytosis and Autophagy in Microglia1663-981210.3389/fphar.2021.770610https://doaj.org/article/275886f91cb34c54afc63941b6fec0bb2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.770610/fullhttps://doaj.org/toc/1663-9812Fluoxetine is a classic antidepressant drug, and its immunomodulatory effects have recently been reported in many disease models. In addition, it has strong antineuroinflammatory effects in stroke and neurodegenerative animal models. However, the effect of fluoxetine on microglia phagocytosis and its molecular mechanisms have not yet been studied. In this study, we investigated whether fluoxetine has a regulatory effect on microglial function. Microglia cell lines and primary mouse microglia were treated with fluoxetine, and the production of inflammatory cytokines and neurotrophic factors and the phagocytosis of amyloid β were measured. Fluoxetine significantly attenuated the production of lipopolysaccharide-induced proinflammatory cytokines and oxidative stress in microglia. Fluoxetine also significantly potentiated microglia phagocytosis and autophagy. In addition, autophagy flux inhibitors attenuated fluoxetine-induced phagocytosis. In conclusion, fluoxetine induces autophagy and potentiates phagocytosis in microglia, which can be a novel molecular mechanism of the neuroinflammatory and neuroprotective effects of fluoxetine.Sung Hee ParkYoung-Sun LeeYoung-Sun LeeHyun-Jeong YangGyun Jee SongGyun Jee SongFrontiers Media S.A.articlefluoxetinemicrogliaphagocytosisautophagyneuroinflammationTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	fluoxetine microglia phagocytosis autophagy neuroinflammation Therapeutics. Pharmacology RM1-950
spellingShingle	fluoxetine microglia phagocytosis autophagy neuroinflammation Therapeutics. Pharmacology RM1-950 Sung Hee Park Young-Sun Lee Young-Sun Lee Hyun-Jeong Yang Gyun Jee Song Gyun Jee Song Fluoxetine Potentiates Phagocytosis and Autophagy in Microglia
description	Fluoxetine is a classic antidepressant drug, and its immunomodulatory effects have recently been reported in many disease models. In addition, it has strong antineuroinflammatory effects in stroke and neurodegenerative animal models. However, the effect of fluoxetine on microglia phagocytosis and its molecular mechanisms have not yet been studied. In this study, we investigated whether fluoxetine has a regulatory effect on microglial function. Microglia cell lines and primary mouse microglia were treated with fluoxetine, and the production of inflammatory cytokines and neurotrophic factors and the phagocytosis of amyloid β were measured. Fluoxetine significantly attenuated the production of lipopolysaccharide-induced proinflammatory cytokines and oxidative stress in microglia. Fluoxetine also significantly potentiated microglia phagocytosis and autophagy. In addition, autophagy flux inhibitors attenuated fluoxetine-induced phagocytosis. In conclusion, fluoxetine induces autophagy and potentiates phagocytosis in microglia, which can be a novel molecular mechanism of the neuroinflammatory and neuroprotective effects of fluoxetine.
format	article
author	Sung Hee Park Young-Sun Lee Young-Sun Lee Hyun-Jeong Yang Gyun Jee Song Gyun Jee Song
author_facet	Sung Hee Park Young-Sun Lee Young-Sun Lee Hyun-Jeong Yang Gyun Jee Song Gyun Jee Song
author_sort	Sung Hee Park
title	Fluoxetine Potentiates Phagocytosis and Autophagy in Microglia
title_short	Fluoxetine Potentiates Phagocytosis and Autophagy in Microglia
title_full	Fluoxetine Potentiates Phagocytosis and Autophagy in Microglia
title_fullStr	Fluoxetine Potentiates Phagocytosis and Autophagy in Microglia
title_full_unstemmed	Fluoxetine Potentiates Phagocytosis and Autophagy in Microglia
title_sort	fluoxetine potentiates phagocytosis and autophagy in microglia
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/275886f91cb34c54afc63941b6fec0bb
work_keys_str_mv	AT sungheepark fluoxetinepotentiatesphagocytosisandautophagyinmicroglia AT youngsunlee fluoxetinepotentiatesphagocytosisandautophagyinmicroglia AT youngsunlee fluoxetinepotentiatesphagocytosisandautophagyinmicroglia AT hyunjeongyang fluoxetinepotentiatesphagocytosisandautophagyinmicroglia AT gyunjeesong fluoxetinepotentiatesphagocytosisandautophagyinmicroglia AT gyunjeesong fluoxetinepotentiatesphagocytosisandautophagyinmicroglia
_version_	1718405343743049728

Fluoxetine Potentiates Phagocytosis and Autophagy in Microglia

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