The Dimension of Time in Host-Microbiome Interactions

ABSTRACT The intestinal microbiota contains trillions of commensal microorganisms that shape multiple aspects of host physiology and disease. In contrast to the host’s genome, the microbiome is amenable to change over the course of an organism’s lifetime, providing an opportunity to therapeutically...

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Autores principales:	Giulia T. Uhr, Lenka Dohnalová, Christoph A. Thaiss
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	microbiome short-term and long-term interventions temporal dynamics Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/2758dfeb0e7e4d7aa13fcf3bf7e1e44a
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spelling	oai:doaj.org-article:2758dfeb0e7e4d7aa13fcf3bf7e1e44a2021-12-02T18:39:16ZThe Dimension of Time in Host-Microbiome Interactions10.1128/mSystems.00216-182379-5077https://doaj.org/article/2758dfeb0e7e4d7aa13fcf3bf7e1e44a2019-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00216-18https://doaj.org/toc/2379-5077ABSTRACT The intestinal microbiota contains trillions of commensal microorganisms that shape multiple aspects of host physiology and disease. In contrast to the host’s genome, the microbiome is amenable to change over the course of an organism’s lifetime, providing an opportunity to therapeutically modulate the microbiome’s impact on human pathophysiology. In this Perspective, we highlight environmental factors that regulate the temporal dynamics of the intestinal microbiome, with a particular focus on the different time scales at which they act. We propose that the identification of transient and intermediate states of microbiome responses to perturbations is essential for understanding the rules that govern the behavior of this ecosystem. The delineation of microbiome dynamics is also helpful for distinguishing cause and effect in microbiome responses to environmental stimuli. Understanding the dimension of time in host-microbiome interactions is therefore critical for therapeutic strategies that aim at short-term or long-term engineering of the intestinal microbial community.Giulia T. UhrLenka DohnalováChristoph A. ThaissAmerican Society for Microbiologyarticlemicrobiomeshort-term and long-term interventionstemporal dynamicsMicrobiologyQR1-502ENmSystems, Vol 4, Iss 1 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	microbiome short-term and long-term interventions temporal dynamics Microbiology QR1-502
spellingShingle	microbiome short-term and long-term interventions temporal dynamics Microbiology QR1-502 Giulia T. Uhr Lenka Dohnalová Christoph A. Thaiss The Dimension of Time in Host-Microbiome Interactions
description	ABSTRACT The intestinal microbiota contains trillions of commensal microorganisms that shape multiple aspects of host physiology and disease. In contrast to the host’s genome, the microbiome is amenable to change over the course of an organism’s lifetime, providing an opportunity to therapeutically modulate the microbiome’s impact on human pathophysiology. In this Perspective, we highlight environmental factors that regulate the temporal dynamics of the intestinal microbiome, with a particular focus on the different time scales at which they act. We propose that the identification of transient and intermediate states of microbiome responses to perturbations is essential for understanding the rules that govern the behavior of this ecosystem. The delineation of microbiome dynamics is also helpful for distinguishing cause and effect in microbiome responses to environmental stimuli. Understanding the dimension of time in host-microbiome interactions is therefore critical for therapeutic strategies that aim at short-term or long-term engineering of the intestinal microbial community.
format	article
author	Giulia T. Uhr Lenka Dohnalová Christoph A. Thaiss
author_facet	Giulia T. Uhr Lenka Dohnalová Christoph A. Thaiss
author_sort	Giulia T. Uhr
title	The Dimension of Time in Host-Microbiome Interactions
title_short	The Dimension of Time in Host-Microbiome Interactions
title_full	The Dimension of Time in Host-Microbiome Interactions
title_fullStr	The Dimension of Time in Host-Microbiome Interactions
title_full_unstemmed	The Dimension of Time in Host-Microbiome Interactions
title_sort	dimension of time in host-microbiome interactions
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/2758dfeb0e7e4d7aa13fcf3bf7e1e44a
work_keys_str_mv	AT giuliatuhr thedimensionoftimeinhostmicrobiomeinteractions AT lenkadohnalova thedimensionoftimeinhostmicrobiomeinteractions AT christophathaiss thedimensionoftimeinhostmicrobiomeinteractions AT giuliatuhr dimensionoftimeinhostmicrobiomeinteractions AT lenkadohnalova dimensionoftimeinhostmicrobiomeinteractions AT christophathaiss dimensionoftimeinhostmicrobiomeinteractions
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The Dimension of Time in Host-Microbiome Interactions

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