The comparison of different daidzein-PLGA nanoparticles in increasing its oral bioavailability

Yiran Ma, Xinyi Zhao, Jian Li, Qi ShenSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, ChinaAbstract: The aim of this research was to increase the oral bioavailability of daidzein by the formulations of poly(lactic-co-glycolic) acid (PLGA) nanoparticles loaded with daidzein. Amongst the...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ma YR, Zhao XY, Li J, Shen Q
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/275a513c8b984e94ac1757ed4698e519
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:275a513c8b984e94ac1757ed4698e519
record_format	dspace
spelling	oai:doaj.org-article:275a513c8b984e94ac1757ed4698e5192021-12-02T00:18:07ZThe comparison of different daidzein-PLGA nanoparticles in increasing its oral bioavailability1176-91141178-2013https://doaj.org/article/275a513c8b984e94ac1757ed4698e5192012-02-01T00:00:00Zhttp://www.dovepress.com/the-comparison-of-different-daidzein-plga-nanoparticles-in-increasing--a9197https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Yiran Ma, Xinyi Zhao, Jian Li, Qi ShenSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, ChinaAbstract: The aim of this research was to increase the oral bioavailability of daidzein by the formulations of poly(lactic-co-glycolic) acid (PLGA) nanoparticles loaded with daidzein. Amongst the various traditional and novel techniques of preparing daidzein-loaded PLGA nanoparticles, daidzein-loaded phospholipid complexes PLGA nanoparticles and daidzein-loaded cyclodextrin inclusion complexes PLGA nanoparticles were selected. The average drug entrapment efficiency, particle size, and zeta potential of daidzein-loaded phospholipid complexes PLGA nanoparticles and daidzein-loaded cyclodextrin inclusion complexes PLGA nanoparticles were 81.9% &plusmn; 5%, 309.2 &plusmn; 14.0 nm, -32.14 &plusmn; 2.53 mV and 83.2% &plusmn; 7.2%, 323.2 &plusmn; 4.8 nm, -18.73 &plusmn; 1.68 mV, respectively. The morphological characterization of nanoparticles was observed with scanning electron microscopy by stereological method and the physicochemical state of nanoparticles was valued by differential scanning calorimetry. The in vitro drug-release profile of both nanoparticle formulations fitted the Weibull dynamic equation. Pharmacokinetic studies demonstrated that after oral administration of daidzein-loaded phospholipid complexes PLGA nanoparticles and daidzein-loaded cyclodextrin inclusion complexes PLGA nanoparticles to rats at a dose of 10 mg/kg, relative bioavailability was enhanced about 5.57- and 8.85-fold, respectively, compared to daidzein suspension as control. These results describe an effective strategy for oral delivery of daidzein-loaded PLGA nanoparticles and might provide a fresh approach to enhancing the bioavailability of drugs with poor lipophilic and poor hydrophilic properties.Keywords: daidzein, phospholipid complexes, cyclodextrin inclusion complexes, PLGA, nanoparticlesMa YRZhao XYLi JShen QDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 559-570 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Ma YR Zhao XY Li J Shen Q The comparison of different daidzein-PLGA nanoparticles in increasing its oral bioavailability
description	Yiran Ma, Xinyi Zhao, Jian Li, Qi ShenSchool of Pharmacy, Shanghai Jiao Tong University, Shanghai, ChinaAbstract: The aim of this research was to increase the oral bioavailability of daidzein by the formulations of poly(lactic-co-glycolic) acid (PLGA) nanoparticles loaded with daidzein. Amongst the various traditional and novel techniques of preparing daidzein-loaded PLGA nanoparticles, daidzein-loaded phospholipid complexes PLGA nanoparticles and daidzein-loaded cyclodextrin inclusion complexes PLGA nanoparticles were selected. The average drug entrapment efficiency, particle size, and zeta potential of daidzein-loaded phospholipid complexes PLGA nanoparticles and daidzein-loaded cyclodextrin inclusion complexes PLGA nanoparticles were 81.9% &plusmn; 5%, 309.2 &plusmn; 14.0 nm, -32.14 &plusmn; 2.53 mV and 83.2% &plusmn; 7.2%, 323.2 &plusmn; 4.8 nm, -18.73 &plusmn; 1.68 mV, respectively. The morphological characterization of nanoparticles was observed with scanning electron microscopy by stereological method and the physicochemical state of nanoparticles was valued by differential scanning calorimetry. The in vitro drug-release profile of both nanoparticle formulations fitted the Weibull dynamic equation. Pharmacokinetic studies demonstrated that after oral administration of daidzein-loaded phospholipid complexes PLGA nanoparticles and daidzein-loaded cyclodextrin inclusion complexes PLGA nanoparticles to rats at a dose of 10 mg/kg, relative bioavailability was enhanced about 5.57- and 8.85-fold, respectively, compared to daidzein suspension as control. These results describe an effective strategy for oral delivery of daidzein-loaded PLGA nanoparticles and might provide a fresh approach to enhancing the bioavailability of drugs with poor lipophilic and poor hydrophilic properties.Keywords: daidzein, phospholipid complexes, cyclodextrin inclusion complexes, PLGA, nanoparticles
format	article
author	Ma YR Zhao XY Li J Shen Q
author_facet	Ma YR Zhao XY Li J Shen Q
author_sort	Ma YR
title	The comparison of different daidzein-PLGA nanoparticles in increasing its oral bioavailability
title_short	The comparison of different daidzein-PLGA nanoparticles in increasing its oral bioavailability
title_full	The comparison of different daidzein-PLGA nanoparticles in increasing its oral bioavailability
title_fullStr	The comparison of different daidzein-PLGA nanoparticles in increasing its oral bioavailability
title_full_unstemmed	The comparison of different daidzein-PLGA nanoparticles in increasing its oral bioavailability
title_sort	comparison of different daidzein-plga nanoparticles in increasing its oral bioavailability
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/275a513c8b984e94ac1757ed4698e519
work_keys_str_mv	AT mayr thecomparisonofdifferentdaidzeinplgananoparticlesinincreasingitsoralbioavailability AT zhaoxy thecomparisonofdifferentdaidzeinplgananoparticlesinincreasingitsoralbioavailability AT lij thecomparisonofdifferentdaidzeinplgananoparticlesinincreasingitsoralbioavailability AT shenq thecomparisonofdifferentdaidzeinplgananoparticlesinincreasingitsoralbioavailability AT mayr comparisonofdifferentdaidzeinplgananoparticlesinincreasingitsoralbioavailability AT zhaoxy comparisonofdifferentdaidzeinplgananoparticlesinincreasingitsoralbioavailability AT lij comparisonofdifferentdaidzeinplgananoparticlesinincreasingitsoralbioavailability AT shenq comparisonofdifferentdaidzeinplgananoparticlesinincreasingitsoralbioavailability
_version_	1718403790182285312

The comparison of different daidzein-PLGA nanoparticles in increasing its oral bioavailability

Ejemplares similares