Emergence of a Plasmid-Encoded Resistance-Nodulation-Division Efflux Pump Conferring Resistance to Multiple Drugs, Including Tigecycline, in <named-content content-type="genus-species">Klebsiella pneumoniae</named-content>

Emergence of a Plasmid-Encoded Resistance-Nodulation-Division Efflux Pump Conferring Resistance to Multiple Drugs, Including Tigecycline, in <named-content content-type="genus-species">Klebsiella pneumoniae</named-content>

ABSTRACT Transporters belonging to the chromosomally encoded resistance-nodulation-division (RND) superfamily mediate multidrug resistance in Gram-negative bacteria. However, the cotransfer of large gene clusters encoding RND-type pumps from the chromosome to a plasmid appears infrequent, and no pla...

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Main Authors: Luchao Lv, Miao Wan, Chengzhen Wang, Xun Gao, Qiwen Yang, Sally R. Partridge, Yang Wang, Zhiyong Zong, Yohei Doi, Jianzhong Shen, Peiyao Jia, Qianhua Song, Qianhui Zhang, Jun Yang, Xianhui Huang, Minggui Wang, Jian-Hua Liu
Format: article
Language:EN
Published: American Society for Microbiology 2020
Subjects:
Enterobacteriaceae
antimicrobial agents
efflux pumps
mechanisms of resistance
multidrug resistance
plasmid-mediated resistance
Microbiology
QR1-502
Online Access:https://doaj.org/article/275a9babc0f443eb9dcb6b4e5a071b96
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