Enhanced osseointegration through direct energy deposition porous coating for cementless orthopedic implant fixation

Abstract Direct energy deposition (DED) is a newly developed 3D metal printing technique that can be utilized on a porous surface coating of joint implants, however there is still a lack of studies on what advantages DED has over conventional techniques. We conducted a systematic mechanical and biol...

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Autores principales:	Dong Jin Ryu, Ara Jung, Hun Yeong Ban, Tae Yang Kwak, Eun Joo Shin, Bomi Gweon, Dohyung Lim, Joon Ho Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/275bf498a0c640f7b1bf04260a2549eb
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spelling	oai:doaj.org-article:275bf498a0c640f7b1bf04260a2549eb2021-11-21T12:25:22ZEnhanced osseointegration through direct energy deposition porous coating for cementless orthopedic implant fixation10.1038/s41598-021-01739-92045-2322https://doaj.org/article/275bf498a0c640f7b1bf04260a2549eb2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01739-9https://doaj.org/toc/2045-2322Abstract Direct energy deposition (DED) is a newly developed 3D metal printing technique that can be utilized on a porous surface coating of joint implants, however there is still a lack of studies on what advantages DED has over conventional techniques. We conducted a systematic mechanical and biological comparative study of porous coatings prepared using the DED method and other commercially available technologies including titanium plasma spray (TPS), and powder bed fusion (PBF). DED showed higher porosity surface (48.54%) than TPS (21.4%) and PBF (35.91%) with comparable fatigue cycle. At initial cell adhesion, cells on DED and PBF surface appeared to spread well with distinct actin stress fibers through immunofluorescence study. It means that the osteoblasts bind more strongly to the DED and PBF surface. Also, DED surface showed higher cell proliferation (1.27 times higher than TPS and PBF) and osteoblast cell activity (1.28 times higher than PBF) for 2 weeks culture in vitro test. In addition, DED surface showed better bone to implant contact and new bone formation than TPS in in vivo study. DED surface also showed consistently good osseointegration performance throughout the early and late period of osseointegration. Collectively, these results show that the DED coating method is an innovative technology that can be utilized to make cementless joint implants.Dong Jin RyuAra JungHun Yeong BanTae Yang KwakEun Joo ShinBomi GweonDohyung LimJoon Ho WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dong Jin Ryu Ara Jung Hun Yeong Ban Tae Yang Kwak Eun Joo Shin Bomi Gweon Dohyung Lim Joon Ho Wang Enhanced osseointegration through direct energy deposition porous coating for cementless orthopedic implant fixation
description	Abstract Direct energy deposition (DED) is a newly developed 3D metal printing technique that can be utilized on a porous surface coating of joint implants, however there is still a lack of studies on what advantages DED has over conventional techniques. We conducted a systematic mechanical and biological comparative study of porous coatings prepared using the DED method and other commercially available technologies including titanium plasma spray (TPS), and powder bed fusion (PBF). DED showed higher porosity surface (48.54%) than TPS (21.4%) and PBF (35.91%) with comparable fatigue cycle. At initial cell adhesion, cells on DED and PBF surface appeared to spread well with distinct actin stress fibers through immunofluorescence study. It means that the osteoblasts bind more strongly to the DED and PBF surface. Also, DED surface showed higher cell proliferation (1.27 times higher than TPS and PBF) and osteoblast cell activity (1.28 times higher than PBF) for 2 weeks culture in vitro test. In addition, DED surface showed better bone to implant contact and new bone formation than TPS in in vivo study. DED surface also showed consistently good osseointegration performance throughout the early and late period of osseointegration. Collectively, these results show that the DED coating method is an innovative technology that can be utilized to make cementless joint implants.
format	article
author	Dong Jin Ryu Ara Jung Hun Yeong Ban Tae Yang Kwak Eun Joo Shin Bomi Gweon Dohyung Lim Joon Ho Wang
author_facet	Dong Jin Ryu Ara Jung Hun Yeong Ban Tae Yang Kwak Eun Joo Shin Bomi Gweon Dohyung Lim Joon Ho Wang
author_sort	Dong Jin Ryu
title	Enhanced osseointegration through direct energy deposition porous coating for cementless orthopedic implant fixation
title_short	Enhanced osseointegration through direct energy deposition porous coating for cementless orthopedic implant fixation
title_full	Enhanced osseointegration through direct energy deposition porous coating for cementless orthopedic implant fixation
title_fullStr	Enhanced osseointegration through direct energy deposition porous coating for cementless orthopedic implant fixation
title_full_unstemmed	Enhanced osseointegration through direct energy deposition porous coating for cementless orthopedic implant fixation
title_sort	enhanced osseointegration through direct energy deposition porous coating for cementless orthopedic implant fixation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/275bf498a0c640f7b1bf04260a2549eb
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Enhanced osseointegration through direct energy deposition porous coating for cementless orthopedic implant fixation

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