Adaptive Mistranslation Accelerates the Evolution of Fluconazole Resistance and Induces Major Genomic and Gene Expression Alterations in <named-content content-type="genus-species">Candida albicans</named-content>

Adaptive Mistranslation Accelerates the Evolution of Fluconazole Resistance and Induces Major Genomic and Gene Expression Alterations in <named-content content-type="genus-species">Candida albicans</named-content>

ABSTRACT Regulated erroneous protein translation (adaptive mistranslation) increases proteome diversity and produces advantageous phenotypic variability in the human pathogen Candida albicans. It also increases fitness in the presence of fluconazole, but the underlying molecular mechanism is not und...

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Autores principales: Tobias Weil, Rodrigo Santamaría, Wanseon Lee, Johan Rung, Noemi Tocci, Darren Abbey, Ana R. Bezerra, Laura Carreto, Gabriela R. Moura, Mónica Bayés, Ivo G. Gut, Attila Csikasz-Nagy, Duccio Cavalieri, Judith Berman, Manuel A. S. Santos
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2017
Materias:
Candida albicans
fluconazole
LOH
aneuploidy
codon ambiguity
drug resistance evolution
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/27634fd55d184dabb3cf213225caa91a
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