A positive feedback loop bi-stably activates fibroblasts

Normal adult tissue fibroblasts can be activated during wound healing, pathologic fibrosis and in cancer stroma, but the regulatory network that controls its dynamics is unknown. Here the authors show that fibroblasts are activated by a positive feedback loop formed by Twist1, Prrx1, and Tenascin-C...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	So-Young Yeo, Keun-Woo Lee, Dongkwan Shin, Sugyun An, Kwang-Hyun Cho, Seok-Hyung Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/2764ab54e1634e5dbd32e110b5ef0b15
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:2764ab54e1634e5dbd32e110b5ef0b15
record_format	dspace
spelling	oai:doaj.org-article:2764ab54e1634e5dbd32e110b5ef0b152021-12-02T17:32:32ZA positive feedback loop bi-stably activates fibroblasts10.1038/s41467-018-05274-62041-1723https://doaj.org/article/2764ab54e1634e5dbd32e110b5ef0b152018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05274-6https://doaj.org/toc/2041-1723Normal adult tissue fibroblasts can be activated during wound healing, pathologic fibrosis and in cancer stroma, but the regulatory network that controls its dynamics is unknown. Here the authors show that fibroblasts are activated by a positive feedback loop formed by Twist1, Prrx1, and Tenascin-C bi-stably.So-Young YeoKeun-Woo LeeDongkwan ShinSugyun AnKwang-Hyun ChoSeok-Hyung KimNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q So-Young Yeo Keun-Woo Lee Dongkwan Shin Sugyun An Kwang-Hyun Cho Seok-Hyung Kim A positive feedback loop bi-stably activates fibroblasts
description	Normal adult tissue fibroblasts can be activated during wound healing, pathologic fibrosis and in cancer stroma, but the regulatory network that controls its dynamics is unknown. Here the authors show that fibroblasts are activated by a positive feedback loop formed by Twist1, Prrx1, and Tenascin-C bi-stably.
format	article
author	So-Young Yeo Keun-Woo Lee Dongkwan Shin Sugyun An Kwang-Hyun Cho Seok-Hyung Kim
author_facet	So-Young Yeo Keun-Woo Lee Dongkwan Shin Sugyun An Kwang-Hyun Cho Seok-Hyung Kim
author_sort	So-Young Yeo
title	A positive feedback loop bi-stably activates fibroblasts
title_short	A positive feedback loop bi-stably activates fibroblasts
title_full	A positive feedback loop bi-stably activates fibroblasts
title_fullStr	A positive feedback loop bi-stably activates fibroblasts
title_full_unstemmed	A positive feedback loop bi-stably activates fibroblasts
title_sort	positive feedback loop bi-stably activates fibroblasts
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/2764ab54e1634e5dbd32e110b5ef0b15
work_keys_str_mv	AT soyoungyeo apositivefeedbackloopbistablyactivatesfibroblasts AT keunwoolee apositivefeedbackloopbistablyactivatesfibroblasts AT dongkwanshin apositivefeedbackloopbistablyactivatesfibroblasts AT sugyunan apositivefeedbackloopbistablyactivatesfibroblasts AT kwanghyuncho apositivefeedbackloopbistablyactivatesfibroblasts AT seokhyungkim apositivefeedbackloopbistablyactivatesfibroblasts AT soyoungyeo positivefeedbackloopbistablyactivatesfibroblasts AT keunwoolee positivefeedbackloopbistablyactivatesfibroblasts AT dongkwanshin positivefeedbackloopbistablyactivatesfibroblasts AT sugyunan positivefeedbackloopbistablyactivatesfibroblasts AT kwanghyuncho positivefeedbackloopbistablyactivatesfibroblasts AT seokhyungkim positivefeedbackloopbistablyactivatesfibroblasts
_version_	1718380235494260736

A positive feedback loop bi-stably activates fibroblasts

Ejemplares similares