The results of intragastric рH-monitoring related to stress ulcer prophylaxis method in comatose patients

Aim. Analyzing dynamics of intragastric рН related to stress ulcer prophylaxis method in comatose patients. Materials and Methods. The prospective study included 100 comatose patients with brain stroke with consciousness level of 5-8 by Glasgow Coma Scale. All patients were given tube enteral nu...

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Autores principales:	U.A. Fesenko, K.M. Loboyko
Formato:	article
Lenguaje:	EN UK
Publicado:	Danylo Halytsky Lviv National Medical University 2016
Materias:	stress ulcer prophylaxis, intragastric рн, coma, brain stroke Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/2769edc39c704172b27ce57a687760a1
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spelling	oai:doaj.org-article:2769edc39c704172b27ce57a687760a12021-11-10T19:50:05ZThe results of intragastric рH-monitoring related to stress ulcer prophylaxis method in comatose patients1029-42442415-3303https://doaj.org/article/2769edc39c704172b27ce57a687760a12016-12-01T00:00:00Zhttps://amljournal.com/index.php/journal/article/view/173https://doaj.org/toc/1029-4244https://doaj.org/toc/2415-3303Aim. Analyzing dynamics of intragastric рН related to stress ulcer prophylaxis method in comatose patients. Materials and Methods. The prospective study included 100 comatose patients with brain stroke with consciousness level of 5-8 by Glasgow Coma Scale. All patients were given tube enteral nutrition . The patients were divided into three groups: group HB (n=18) received Н-2-histamine blocker agent; group IPI (n=38) received ion pump inhibitor, and group EN (n=44) received no medication for stress ulcer prophylaxis. The maximal, minimal and average daily intragastric рН levels were analyzed on the 1st, 3rd, and 5th days of stay in the intensive care unit. Results and Discussion. The average daily intragastric pH level in group HB was 2,4±0,44 on day 1,- 4,54±1,5 on day 3, and- 3,85±0,77 on day 5. This parameter in the group IPI was 1,66±0,45 on day 1, 5,9±1,43 on day 3, and 5,37±1,44 on day 5; in the group EN: 2,98±0,65 on day 1,- 3,41±0,45 on day 3, and 3,45±0,5 on day 5. Conclusions. Early enteral nutrition ensures the optimal level of intragastric pH. The ion pump inhibitors provide more potent inhibition of acidity of gastric content compared to the Н-2-histamine blocker agents. Intragastric рН-monitoring is useful in evaluating the stress ulcer prophylaxis effectiveness in comatose patients.U.A. FesenkoK.M. LoboykoDanylo Halytsky Lviv National Medical Universityarticlestress ulcer prophylaxis, intragastric рн, coma, brain strokeMedicine (General)R5-920ENUKActa Medica Leopoliensia, Vol 22, Iss 4, Pp 27-31 (2016)
institution	DOAJ
collection	DOAJ
language	EN UK
topic	stress ulcer prophylaxis, intragastric рн, coma, brain stroke Medicine (General) R5-920
spellingShingle	stress ulcer prophylaxis, intragastric рн, coma, brain stroke Medicine (General) R5-920 U.A. Fesenko K.M. Loboyko The results of intragastric рH-monitoring related to stress ulcer prophylaxis method in comatose patients
description	Aim. Analyzing dynamics of intragastric рН related to stress ulcer prophylaxis method in comatose patients. Materials and Methods. The prospective study included 100 comatose patients with brain stroke with consciousness level of 5-8 by Glasgow Coma Scale. All patients were given tube enteral nutrition . The patients were divided into three groups: group HB (n=18) received Н-2-histamine blocker agent; group IPI (n=38) received ion pump inhibitor, and group EN (n=44) received no medication for stress ulcer prophylaxis. The maximal, minimal and average daily intragastric рН levels were analyzed on the 1st, 3rd, and 5th days of stay in the intensive care unit. Results and Discussion. The average daily intragastric pH level in group HB was 2,4±0,44 on day 1,- 4,54±1,5 on day 3, and- 3,85±0,77 on day 5. This parameter in the group IPI was 1,66±0,45 on day 1, 5,9±1,43 on day 3, and 5,37±1,44 on day 5; in the group EN: 2,98±0,65 on day 1,- 3,41±0,45 on day 3, and 3,45±0,5 on day 5. Conclusions. Early enteral nutrition ensures the optimal level of intragastric pH. The ion pump inhibitors provide more potent inhibition of acidity of gastric content compared to the Н-2-histamine blocker agents. Intragastric рН-monitoring is useful in evaluating the stress ulcer prophylaxis effectiveness in comatose patients.
format	article
author	U.A. Fesenko K.M. Loboyko
author_facet	U.A. Fesenko K.M. Loboyko
author_sort	U.A. Fesenko
title	The results of intragastric рH-monitoring related to stress ulcer prophylaxis method in comatose patients
title_short	The results of intragastric рH-monitoring related to stress ulcer prophylaxis method in comatose patients
title_full	The results of intragastric рH-monitoring related to stress ulcer prophylaxis method in comatose patients
title_fullStr	The results of intragastric рH-monitoring related to stress ulcer prophylaxis method in comatose patients
title_full_unstemmed	The results of intragastric рH-monitoring related to stress ulcer prophylaxis method in comatose patients
title_sort	results of intragastric рh-monitoring related to stress ulcer prophylaxis method in comatose patients
publisher	Danylo Halytsky Lviv National Medical University
publishDate	2016
url	https://doaj.org/article/2769edc39c704172b27ce57a687760a1
work_keys_str_mv	AT uafesenko theresultsofintragastricrhmonitoringrelatedtostressulcerprophylaxismethodincomatosepatients AT kmloboyko theresultsofintragastricrhmonitoringrelatedtostressulcerprophylaxismethodincomatosepatients AT uafesenko resultsofintragastricrhmonitoringrelatedtostressulcerprophylaxismethodincomatosepatients AT kmloboyko resultsofintragastricrhmonitoringrelatedtostressulcerprophylaxismethodincomatosepatients
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The results of intragastric рH-monitoring related to stress ulcer prophylaxis method in comatose patients

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