FREQUENCY, RISK FACTORS, TREATMENT AND OUTCOMES OF HYPERINSULINEMIC HYPOGLYCEMIA IN NEONATES PRESENTING WITH PROLONGED HYPOGLYCEMIA IN A TERTIARY CARE HOSPITAL OF KARACHI, PAKISTAN

Objective: To identify frequency of hyperinsulinemic hypoglycemia in neonates with prolonged hypoglycemia, its risk factors, treatment and outcome. Study Design: Cross-sectional analytical study. Place and Duration of Study: The department of Pediatrics, neonatal unit of a tertiary care hospit...

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Autores principales:	Vinod Kumar Hasija, Waqar Khowaja, Saroop Chand, Adnan Mirza, Shabina Arrif
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2020
Materias:	glucose infusion rate hyperinsulinemic hypoglycemia prolonged hypoglycemia small for gestational age (sga) Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/276db194cfe74b81b8a6c1f3b40154d7
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spelling	oai:doaj.org-article:276db194cfe74b81b8a6c1f3b40154d72021-12-02T17:18:25ZFREQUENCY, RISK FACTORS, TREATMENT AND OUTCOMES OF HYPERINSULINEMIC HYPOGLYCEMIA IN NEONATES PRESENTING WITH PROLONGED HYPOGLYCEMIA IN A TERTIARY CARE HOSPITAL OF KARACHI, PAKISTAN0030-96482411-8842https://doaj.org/article/276db194cfe74b81b8a6c1f3b40154d72020-10-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/5557https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To identify frequency of hyperinsulinemic hypoglycemia in neonates with prolonged hypoglycemia, its risk factors, treatment and outcome. Study Design: Cross-sectional analytical study. Place and Duration of Study: The department of Pediatrics, neonatal unit of a tertiary care hospital, from Jan 2014 to Dec 2018. Methodology: Data on infants with prolonged hypoglycemia was collected retrospectively from hospital medical records. Cases of Hyperinsulinemic hypoglycemia were analyzed for demographic characteristics, associated risk factors, and details of time and age of diagnosis along with the management. Results: Fifty two cases (50.9%) were studied and treated for Hyperinsulinemic hypoglycemia out of 102 with prolong hypoglycemia. Male gender, Pregnancy induced hypertension, maternal diabetes and Small for gestational age were common risk factors associated with hyperinsulinemic hypoglycemia (p<0.05). Mean days taken to maintain normoglycemia on feed and medicine (off IV) was 7.7 ± 3.3, while total duration of medicine required for normoglycemia on feed only was 23.5 ± 2.0 days. Overall 48 cases (92%) were cured, 29 (56%) patients were treated with diazoxide, whereas 3 (6.0%) cases were lost to follow up in outpatient department and 1 (2.0%) patient died. Conclusion: Hyperinsulinemia remains a common cause of prolonged hypoglycemia in neonates. Male gender, Pregnancy induced hypertension, diabetes, and Small for gestational age are associated risk factors. Diazoxide is a safe and effective therapy.Vinod Kumar HasijaWaqar KhowajaSaroop ChandAdnan MirzaShabina ArrifArmy Medical College Rawalpindiarticleglucose infusion ratehyperinsulinemic hypoglycemiaprolonged hypoglycemiasmall for gestational age (sga)MedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 70, Iss 5, Pp 1321-1326 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	glucose infusion rate hyperinsulinemic hypoglycemia prolonged hypoglycemia small for gestational age (sga) Medicine R Medicine (General) R5-920
spellingShingle	glucose infusion rate hyperinsulinemic hypoglycemia prolonged hypoglycemia small for gestational age (sga) Medicine R Medicine (General) R5-920 Vinod Kumar Hasija Waqar Khowaja Saroop Chand Adnan Mirza Shabina Arrif FREQUENCY, RISK FACTORS, TREATMENT AND OUTCOMES OF HYPERINSULINEMIC HYPOGLYCEMIA IN NEONATES PRESENTING WITH PROLONGED HYPOGLYCEMIA IN A TERTIARY CARE HOSPITAL OF KARACHI, PAKISTAN
description	Objective: To identify frequency of hyperinsulinemic hypoglycemia in neonates with prolonged hypoglycemia, its risk factors, treatment and outcome. Study Design: Cross-sectional analytical study. Place and Duration of Study: The department of Pediatrics, neonatal unit of a tertiary care hospital, from Jan 2014 to Dec 2018. Methodology: Data on infants with prolonged hypoglycemia was collected retrospectively from hospital medical records. Cases of Hyperinsulinemic hypoglycemia were analyzed for demographic characteristics, associated risk factors, and details of time and age of diagnosis along with the management. Results: Fifty two cases (50.9%) were studied and treated for Hyperinsulinemic hypoglycemia out of 102 with prolong hypoglycemia. Male gender, Pregnancy induced hypertension, maternal diabetes and Small for gestational age were common risk factors associated with hyperinsulinemic hypoglycemia (p<0.05). Mean days taken to maintain normoglycemia on feed and medicine (off IV) was 7.7 ± 3.3, while total duration of medicine required for normoglycemia on feed only was 23.5 ± 2.0 days. Overall 48 cases (92%) were cured, 29 (56%) patients were treated with diazoxide, whereas 3 (6.0%) cases were lost to follow up in outpatient department and 1 (2.0%) patient died. Conclusion: Hyperinsulinemia remains a common cause of prolonged hypoglycemia in neonates. Male gender, Pregnancy induced hypertension, diabetes, and Small for gestational age are associated risk factors. Diazoxide is a safe and effective therapy.
format	article
author	Vinod Kumar Hasija Waqar Khowaja Saroop Chand Adnan Mirza Shabina Arrif
author_facet	Vinod Kumar Hasija Waqar Khowaja Saroop Chand Adnan Mirza Shabina Arrif
author_sort	Vinod Kumar Hasija
title	FREQUENCY, RISK FACTORS, TREATMENT AND OUTCOMES OF HYPERINSULINEMIC HYPOGLYCEMIA IN NEONATES PRESENTING WITH PROLONGED HYPOGLYCEMIA IN A TERTIARY CARE HOSPITAL OF KARACHI, PAKISTAN
title_short	FREQUENCY, RISK FACTORS, TREATMENT AND OUTCOMES OF HYPERINSULINEMIC HYPOGLYCEMIA IN NEONATES PRESENTING WITH PROLONGED HYPOGLYCEMIA IN A TERTIARY CARE HOSPITAL OF KARACHI, PAKISTAN
title_full	FREQUENCY, RISK FACTORS, TREATMENT AND OUTCOMES OF HYPERINSULINEMIC HYPOGLYCEMIA IN NEONATES PRESENTING WITH PROLONGED HYPOGLYCEMIA IN A TERTIARY CARE HOSPITAL OF KARACHI, PAKISTAN
title_fullStr	FREQUENCY, RISK FACTORS, TREATMENT AND OUTCOMES OF HYPERINSULINEMIC HYPOGLYCEMIA IN NEONATES PRESENTING WITH PROLONGED HYPOGLYCEMIA IN A TERTIARY CARE HOSPITAL OF KARACHI, PAKISTAN
title_full_unstemmed	FREQUENCY, RISK FACTORS, TREATMENT AND OUTCOMES OF HYPERINSULINEMIC HYPOGLYCEMIA IN NEONATES PRESENTING WITH PROLONGED HYPOGLYCEMIA IN A TERTIARY CARE HOSPITAL OF KARACHI, PAKISTAN
title_sort	frequency, risk factors, treatment and outcomes of hyperinsulinemic hypoglycemia in neonates presenting with prolonged hypoglycemia in a tertiary care hospital of karachi, pakistan
publisher	Army Medical College Rawalpindi
publishDate	2020
url	https://doaj.org/article/276db194cfe74b81b8a6c1f3b40154d7
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_version_	1718381075371130880

FREQUENCY, RISK FACTORS, TREATMENT AND OUTCOMES OF HYPERINSULINEMIC HYPOGLYCEMIA IN NEONATES PRESENTING WITH PROLONGED HYPOGLYCEMIA IN A TERTIARY CARE HOSPITAL OF KARACHI, PAKISTAN

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