Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells

Quantitative methods to assess the quality of hPSC-derived organoids have not been developed. Here they present a prediction algorithm to assess the transcriptomic similarity between hPSC-derived organoids and the corresponding human target organs and perform validation on lung bud organoids, antral...

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Autores principales:	Mi-Ok Lee, Su-gi Lee, Cho-Rok Jung, Ye Seul Son, Jae-Woon Ryu, Kwang Bo Jung, Jun-Ho Ahn, Jung-Hwa Oh, Hyang-Ae Lee, Jung Hwa Lim, Janghwan Kim, Insu Jang, Jinhyuk Choi, Jaeeun Jung, Kunhyang Park, Byungwook Lee, Dae-Soo Kim, Mi-Young Son, Hyun-Soo Cho
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/27708e935ee5482783e2d1c6359a3d60
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spelling	oai:doaj.org-article:27708e935ee5482783e2d1c6359a3d602021-12-02T16:17:53ZDevelopment of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells10.1038/s41467-021-24746-w2041-1723https://doaj.org/article/27708e935ee5482783e2d1c6359a3d602021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24746-whttps://doaj.org/toc/2041-1723Quantitative methods to assess the quality of hPSC-derived organoids have not been developed. Here they present a prediction algorithm to assess the transcriptomic similarity between hPSC-derived organoids and the corresponding human target organs and perform validation on lung bud organoids, antral gastric organoids, and cardiomyocytes.Mi-Ok LeeSu-gi LeeCho-Rok JungYe Seul SonJae-Woon RyuKwang Bo JungJun-Ho AhnJung-Hwa OhHyang-Ae LeeJung Hwa LimJanghwan KimInsu JangJinhyuk ChoiJaeeun JungKunhyang ParkByungwook LeeDae-Soo KimMi-Young SonHyun-Soo ChoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mi-Ok Lee Su-gi Lee Cho-Rok Jung Ye Seul Son Jae-Woon Ryu Kwang Bo Jung Jun-Ho Ahn Jung-Hwa Oh Hyang-Ae Lee Jung Hwa Lim Janghwan Kim Insu Jang Jinhyuk Choi Jaeeun Jung Kunhyang Park Byungwook Lee Dae-Soo Kim Mi-Young Son Hyun-Soo Cho Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells
description	Quantitative methods to assess the quality of hPSC-derived organoids have not been developed. Here they present a prediction algorithm to assess the transcriptomic similarity between hPSC-derived organoids and the corresponding human target organs and perform validation on lung bud organoids, antral gastric organoids, and cardiomyocytes.
format	article
author	Mi-Ok Lee Su-gi Lee Cho-Rok Jung Ye Seul Son Jae-Woon Ryu Kwang Bo Jung Jun-Ho Ahn Jung-Hwa Oh Hyang-Ae Lee Jung Hwa Lim Janghwan Kim Insu Jang Jinhyuk Choi Jaeeun Jung Kunhyang Park Byungwook Lee Dae-Soo Kim Mi-Young Son Hyun-Soo Cho
author_facet	Mi-Ok Lee Su-gi Lee Cho-Rok Jung Ye Seul Son Jae-Woon Ryu Kwang Bo Jung Jun-Ho Ahn Jung-Hwa Oh Hyang-Ae Lee Jung Hwa Lim Janghwan Kim Insu Jang Jinhyuk Choi Jaeeun Jung Kunhyang Park Byungwook Lee Dae-Soo Kim Mi-Young Son Hyun-Soo Cho
author_sort	Mi-Ok Lee
title	Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells
title_short	Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells
title_full	Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells
title_fullStr	Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells
title_full_unstemmed	Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells
title_sort	development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/27708e935ee5482783e2d1c6359a3d60
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Development of a quantitative prediction algorithm for target organ-specific similarity of human pluripotent stem cell-derived organoids and cells

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