Serum BDNF concentrations show strong seasonal variation and correlations with the amount of ambient sunlight.

Earlier findings show seasonality in processes and behaviors such as brain plasticity and depression that in part are regulated by Brain-Derived Neurotrophic Factor (BDNF). Based on this we investigated seasonal variation in serum BDNF concentrations in 2,851 persons who took part in the Netherlands...

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Autores principales:	Marc L Molendijk, Judith P M Haffmans, Boudewijn A A Bus, Philip Spinhoven, Brenda W J H Penninx, Jos Prickaerts, Richard C Oude Voshaar, Bernet M Elzinga
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/27739a79ebae4c4f8c3b99d0fb3691f3
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spelling	oai:doaj.org-article:27739a79ebae4c4f8c3b99d0fb3691f32021-11-18T08:10:11ZSerum BDNF concentrations show strong seasonal variation and correlations with the amount of ambient sunlight.1932-620310.1371/journal.pone.0048046https://doaj.org/article/27739a79ebae4c4f8c3b99d0fb3691f32012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23133609/?tool=EBIhttps://doaj.org/toc/1932-6203Earlier findings show seasonality in processes and behaviors such as brain plasticity and depression that in part are regulated by Brain-Derived Neurotrophic Factor (BDNF). Based on this we investigated seasonal variation in serum BDNF concentrations in 2,851 persons who took part in the Netherlands Study of Depression and Anxiety (NESDA). Analyses by month of sampling (monthly n's >196) showed pronounced seasonal variation in serum BDNF concentrations (P<.0001) with increasing concentrations in the spring-summer period (standardized regression weight (ß) = 0.19, P<.0001) and decreasing concentrations in the autumn-winter period (ß = -0.17, P<.0001). Effect sizes [Cohen's d] ranged from 0.27 to 0.66 for monthly significant differences. We found similar seasonal variation for both sexes and for persons with a DSM-IV depression diagnosis and healthy control subjects. In explorative analyses we found that the number of sunshine hours (a major trigger to entrain seasonality) in the week of blood withdrawal and the 10 weeks prior to this event positively correlated with serum BDNF concentrations (Pearson's correlation coefficients ranged: 0.05-0.18) and this could partly explain the observed monthly variation. These results provide strong evidence that serum BDNF concentrations systematically vary over the year. This finding is important for our understanding of those factors that regulate BDNF expression and may provide novel avenues to understand seasonal dependent changes in behavior and illness such as depression. Finally, the findings reported here should be taken into account when designing and interpreting studies on BDNF.Marc L MolendijkJudith P M HaffmansBoudewijn A A BusPhilip SpinhovenBrenda W J H PenninxJos PrickaertsRichard C Oude VoshaarBernet M ElzingaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e48046 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marc L Molendijk Judith P M Haffmans Boudewijn A A Bus Philip Spinhoven Brenda W J H Penninx Jos Prickaerts Richard C Oude Voshaar Bernet M Elzinga Serum BDNF concentrations show strong seasonal variation and correlations with the amount of ambient sunlight.
description	Earlier findings show seasonality in processes and behaviors such as brain plasticity and depression that in part are regulated by Brain-Derived Neurotrophic Factor (BDNF). Based on this we investigated seasonal variation in serum BDNF concentrations in 2,851 persons who took part in the Netherlands Study of Depression and Anxiety (NESDA). Analyses by month of sampling (monthly n's >196) showed pronounced seasonal variation in serum BDNF concentrations (P<.0001) with increasing concentrations in the spring-summer period (standardized regression weight (ß) = 0.19, P<.0001) and decreasing concentrations in the autumn-winter period (ß = -0.17, P<.0001). Effect sizes [Cohen's d] ranged from 0.27 to 0.66 for monthly significant differences. We found similar seasonal variation for both sexes and for persons with a DSM-IV depression diagnosis and healthy control subjects. In explorative analyses we found that the number of sunshine hours (a major trigger to entrain seasonality) in the week of blood withdrawal and the 10 weeks prior to this event positively correlated with serum BDNF concentrations (Pearson's correlation coefficients ranged: 0.05-0.18) and this could partly explain the observed monthly variation. These results provide strong evidence that serum BDNF concentrations systematically vary over the year. This finding is important for our understanding of those factors that regulate BDNF expression and may provide novel avenues to understand seasonal dependent changes in behavior and illness such as depression. Finally, the findings reported here should be taken into account when designing and interpreting studies on BDNF.
format	article
author	Marc L Molendijk Judith P M Haffmans Boudewijn A A Bus Philip Spinhoven Brenda W J H Penninx Jos Prickaerts Richard C Oude Voshaar Bernet M Elzinga
author_facet	Marc L Molendijk Judith P M Haffmans Boudewijn A A Bus Philip Spinhoven Brenda W J H Penninx Jos Prickaerts Richard C Oude Voshaar Bernet M Elzinga
author_sort	Marc L Molendijk
title	Serum BDNF concentrations show strong seasonal variation and correlations with the amount of ambient sunlight.
title_short	Serum BDNF concentrations show strong seasonal variation and correlations with the amount of ambient sunlight.
title_full	Serum BDNF concentrations show strong seasonal variation and correlations with the amount of ambient sunlight.
title_fullStr	Serum BDNF concentrations show strong seasonal variation and correlations with the amount of ambient sunlight.
title_full_unstemmed	Serum BDNF concentrations show strong seasonal variation and correlations with the amount of ambient sunlight.
title_sort	serum bdnf concentrations show strong seasonal variation and correlations with the amount of ambient sunlight.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/27739a79ebae4c4f8c3b99d0fb3691f3
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Serum BDNF concentrations show strong seasonal variation and correlations with the amount of ambient sunlight.

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