External validation of the MRI-DRAGON score: early prediction of stroke outcome after intravenous thrombolysis.

<h4>Background and purpose</h4>The aim of our study was to validate in an independent cohort the MRI-DRAGON score, an adaptation of the (CT-) DRAGON score to predict 3-month outcome in acute ischemic stroke patients undergoing MRI before intravenous thrombolysis (IV-tPA).<h4>Method...

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Autores principales:	Guillaume Turc, Pierre Aguettaz, Nelly Ponchelle-Dequatre, Hilde Hénon, Olivier Naggara, Xavier Leclerc, Charlotte Cordonnier, Didier Leys, Jean-Louis Mas, Catherine Oppenheim
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/27745ea946114296b6c4228d2cc1fb80
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spelling	oai:doaj.org-article:27745ea946114296b6c4228d2cc1fb802021-11-18T08:17:11ZExternal validation of the MRI-DRAGON score: early prediction of stroke outcome after intravenous thrombolysis.1932-620310.1371/journal.pone.0099164https://doaj.org/article/27745ea946114296b6c4228d2cc1fb802014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24896827/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background and purpose</h4>The aim of our study was to validate in an independent cohort the MRI-DRAGON score, an adaptation of the (CT-) DRAGON score to predict 3-month outcome in acute ischemic stroke patients undergoing MRI before intravenous thrombolysis (IV-tPA).<h4>Methods</h4>We reviewed consecutive (2009-2013) anterior circulation stroke patients treated within 4.5 hours by IV-tPA in the Lille stroke unit (France), where MRI is the first-line pretherapeutic work-up. We assessed the discrimination and calibration of the MRI-DRAGON score to predict poor 3-month outcome, defined as modified Rankin Score >2, using c-statistic and the Hosmer-Lemeshow test, respectively.<h4>Results</h4>We included 230 patients (mean ±SD age 70.4±16.0 years, median [IQR] baseline NIHSS 8 [5]-[14]; poor outcome in 78(34%) patients). The c-statistic was 0.81 (95%CI 0.75-0.87), and the Hosmer-Lemeshow test was not significant (p = 0.54).<h4>Conclusions</h4>The MRI-DRAGON score showed good prognostic performance in the external validation cohort. It could therefore be used to inform the patient's relatives about long-term prognosis and help to identify poor responders to IV-tPA alone, who may be candidates for additional therapeutic strategies, if they are otherwise eligible for such procedures based on the institutional criteria.Guillaume TurcPierre AguettazNelly Ponchelle-DequatreHilde HénonOlivier NaggaraXavier LeclercCharlotte CordonnierDidier LeysJean-Louis MasCatherine OppenheimPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 6, p e99164 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guillaume Turc Pierre Aguettaz Nelly Ponchelle-Dequatre Hilde Hénon Olivier Naggara Xavier Leclerc Charlotte Cordonnier Didier Leys Jean-Louis Mas Catherine Oppenheim External validation of the MRI-DRAGON score: early prediction of stroke outcome after intravenous thrombolysis.
description	<h4>Background and purpose</h4>The aim of our study was to validate in an independent cohort the MRI-DRAGON score, an adaptation of the (CT-) DRAGON score to predict 3-month outcome in acute ischemic stroke patients undergoing MRI before intravenous thrombolysis (IV-tPA).<h4>Methods</h4>We reviewed consecutive (2009-2013) anterior circulation stroke patients treated within 4.5 hours by IV-tPA in the Lille stroke unit (France), where MRI is the first-line pretherapeutic work-up. We assessed the discrimination and calibration of the MRI-DRAGON score to predict poor 3-month outcome, defined as modified Rankin Score >2, using c-statistic and the Hosmer-Lemeshow test, respectively.<h4>Results</h4>We included 230 patients (mean ±SD age 70.4±16.0 years, median [IQR] baseline NIHSS 8 [5]-[14]; poor outcome in 78(34%) patients). The c-statistic was 0.81 (95%CI 0.75-0.87), and the Hosmer-Lemeshow test was not significant (p = 0.54).<h4>Conclusions</h4>The MRI-DRAGON score showed good prognostic performance in the external validation cohort. It could therefore be used to inform the patient's relatives about long-term prognosis and help to identify poor responders to IV-tPA alone, who may be candidates for additional therapeutic strategies, if they are otherwise eligible for such procedures based on the institutional criteria.
format	article
author	Guillaume Turc Pierre Aguettaz Nelly Ponchelle-Dequatre Hilde Hénon Olivier Naggara Xavier Leclerc Charlotte Cordonnier Didier Leys Jean-Louis Mas Catherine Oppenheim
author_facet	Guillaume Turc Pierre Aguettaz Nelly Ponchelle-Dequatre Hilde Hénon Olivier Naggara Xavier Leclerc Charlotte Cordonnier Didier Leys Jean-Louis Mas Catherine Oppenheim
author_sort	Guillaume Turc
title	External validation of the MRI-DRAGON score: early prediction of stroke outcome after intravenous thrombolysis.
title_short	External validation of the MRI-DRAGON score: early prediction of stroke outcome after intravenous thrombolysis.
title_full	External validation of the MRI-DRAGON score: early prediction of stroke outcome after intravenous thrombolysis.
title_fullStr	External validation of the MRI-DRAGON score: early prediction of stroke outcome after intravenous thrombolysis.
title_full_unstemmed	External validation of the MRI-DRAGON score: early prediction of stroke outcome after intravenous thrombolysis.
title_sort	external validation of the mri-dragon score: early prediction of stroke outcome after intravenous thrombolysis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/27745ea946114296b6c4228d2cc1fb80
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External validation of the MRI-DRAGON score: early prediction of stroke outcome after intravenous thrombolysis.

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