Bone loss in hepatitis B virus-infected patients can be associated with greater osteoclastic activity independently of the retroviral use

Abstract Nucleoside/nucleotide analogs such as tenofovir, have been used as long-term therapy for the treatment of hepatitis B and side effects such as the reduction in bone mineral density have been associated with their use. To determine the relationships between bone, hormonal, biochemical, and m...

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Autores principales:	Renata Dessordi, Ligia Moriguchi Watanabe, Mariana Palma Guimarães, Elen Almeida Romão, Ana de Lourdes Candolo Martinelli, Rodrigo de Carvalho Santana, Anderson Marliere Navarro
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/27776a7327db4dcf8f4c8d4df2b24432
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spelling	oai:doaj.org-article:27776a7327db4dcf8f4c8d4df2b244322021-12-02T17:15:28ZBone loss in hepatitis B virus-infected patients can be associated with greater osteoclastic activity independently of the retroviral use10.1038/s41598-021-89486-92045-2322https://doaj.org/article/27776a7327db4dcf8f4c8d4df2b244322021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89486-9https://doaj.org/toc/2045-2322Abstract Nucleoside/nucleotide analogs such as tenofovir, have been used as long-term therapy for the treatment of hepatitis B and side effects such as the reduction in bone mineral density have been associated with their use. To determine the relationships between bone, hormonal, biochemical, and mineral parameters in patients with hepatitis B treated with nucleoside/nucleotide antiviral. A cross-sectional study was conducted with 81 adult patients with chronic hepatitis B infection. Dual-energy X-ray absorptiometry (DXA) was performed to assess bone mineral density. Biochemical analyses were performed for osteocalcin, deoxypyridinoline, parathyroid hormone, vitamin D, IGF-1, TSH, testosterone, estradiol, FSH, transaminases, urea, creatinine, calcium, serum and urinary phosphorus, magnesium, and FGF-23, body composition was performed by DXA. Participants, both gender, were divided according to the use of antiretrovirals: Group1: 27 inactive virus carriers without medication; Group2: 27 patients using tenofovir; and Group3: 27 patients using lamivudine or entecavir. DXA readings diagnosed osteopenia in the lumbar spine for 7.4% of individuals in Group1, 15% in Group2, and 3.7% in Group3. For all groups, we observed normal values in bone formation markers, osteocalcin levels as well as parathyroid hormone, insulin growth factor 1, and FGF-23. In all groups, we found increased levels of urinary deoxypyridinoline, a bone resorption marker. Increased levels in the bone resorption markers indicated a high resorptive activity of bone tissue. These data suggested high resorption activity of bone tissue in hepatitis B virus-infected patients independent of the use of antiretrovirals.Renata DessordiLigia Moriguchi WatanabeMariana Palma GuimarãesElen Almeida RomãoAna de Lourdes Candolo MartinelliRodrigo de Carvalho SantanaAnderson Marliere NavarroNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Renata Dessordi Ligia Moriguchi Watanabe Mariana Palma Guimarães Elen Almeida Romão Ana de Lourdes Candolo Martinelli Rodrigo de Carvalho Santana Anderson Marliere Navarro Bone loss in hepatitis B virus-infected patients can be associated with greater osteoclastic activity independently of the retroviral use
description	Abstract Nucleoside/nucleotide analogs such as tenofovir, have been used as long-term therapy for the treatment of hepatitis B and side effects such as the reduction in bone mineral density have been associated with their use. To determine the relationships between bone, hormonal, biochemical, and mineral parameters in patients with hepatitis B treated with nucleoside/nucleotide antiviral. A cross-sectional study was conducted with 81 adult patients with chronic hepatitis B infection. Dual-energy X-ray absorptiometry (DXA) was performed to assess bone mineral density. Biochemical analyses were performed for osteocalcin, deoxypyridinoline, parathyroid hormone, vitamin D, IGF-1, TSH, testosterone, estradiol, FSH, transaminases, urea, creatinine, calcium, serum and urinary phosphorus, magnesium, and FGF-23, body composition was performed by DXA. Participants, both gender, were divided according to the use of antiretrovirals: Group1: 27 inactive virus carriers without medication; Group2: 27 patients using tenofovir; and Group3: 27 patients using lamivudine or entecavir. DXA readings diagnosed osteopenia in the lumbar spine for 7.4% of individuals in Group1, 15% in Group2, and 3.7% in Group3. For all groups, we observed normal values in bone formation markers, osteocalcin levels as well as parathyroid hormone, insulin growth factor 1, and FGF-23. In all groups, we found increased levels of urinary deoxypyridinoline, a bone resorption marker. Increased levels in the bone resorption markers indicated a high resorptive activity of bone tissue. These data suggested high resorption activity of bone tissue in hepatitis B virus-infected patients independent of the use of antiretrovirals.
format	article
author	Renata Dessordi Ligia Moriguchi Watanabe Mariana Palma Guimarães Elen Almeida Romão Ana de Lourdes Candolo Martinelli Rodrigo de Carvalho Santana Anderson Marliere Navarro
author_facet	Renata Dessordi Ligia Moriguchi Watanabe Mariana Palma Guimarães Elen Almeida Romão Ana de Lourdes Candolo Martinelli Rodrigo de Carvalho Santana Anderson Marliere Navarro
author_sort	Renata Dessordi
title	Bone loss in hepatitis B virus-infected patients can be associated with greater osteoclastic activity independently of the retroviral use
title_short	Bone loss in hepatitis B virus-infected patients can be associated with greater osteoclastic activity independently of the retroviral use
title_full	Bone loss in hepatitis B virus-infected patients can be associated with greater osteoclastic activity independently of the retroviral use
title_fullStr	Bone loss in hepatitis B virus-infected patients can be associated with greater osteoclastic activity independently of the retroviral use
title_full_unstemmed	Bone loss in hepatitis B virus-infected patients can be associated with greater osteoclastic activity independently of the retroviral use
title_sort	bone loss in hepatitis b virus-infected patients can be associated with greater osteoclastic activity independently of the retroviral use
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/27776a7327db4dcf8f4c8d4df2b24432
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Bone loss in hepatitis B virus-infected patients can be associated with greater osteoclastic activity independently of the retroviral use

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