Sedative Effect and Standardization Parameters of Herbal Medicinal Product Obtained from the Ocimum americanum L. Herb

Sedative phytomedications continue to play an important role in the management of a considerable amount of anxiety symptoms because of the various side effects of synthetic sedatives and tranquilizers. However, developing new herbal drugs needs their appropriate quality control according to the rele...

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Autores principales:	Shanaida M., Golembiovska O., Jasicka-Misiak I., Oleshchuk O., Beley N., Kernychna I., Wieczorek P.P.
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2021
Materias:	american basil herb tincture sedative activity polyphenols linalool chromatographic analysis Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/2778697a75f04732a0719398dbee5228
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spelling	oai:doaj.org-article:2778697a75f04732a0719398dbee52282021-12-05T14:11:05ZSedative Effect and Standardization Parameters of Herbal Medicinal Product Obtained from the Ocimum americanum L. Herb2453-672510.2478/afpuc-2020-0015https://doaj.org/article/2778697a75f04732a0719398dbee52282021-04-01T00:00:00Zhttps://doi.org/10.2478/afpuc-2020-0015https://doaj.org/toc/2453-6725Sedative phytomedications continue to play an important role in the management of a considerable amount of anxiety symptoms because of the various side effects of synthetic sedatives and tranquilizers. However, developing new herbal drugs needs their appropriate quality control according to the relevant requirements. The aim of the study was to determine the sedative properties of the tinctures obtained from the American basil (Ocimum americanum L., Lamiaceae Martinov family) herb and to develop the standardization parameters for the promising herbal medicinal product. The open field test was used to evaluate the sedative effect of the prepared tinctures: (1) with the added of O. americanum essential oil (OATEs) and (2) without adding O. americanum essential oil (OAT). The standardization parameters for the OATEs were developed using validated High-Performance Thin Layer Chromatography (HPTLC) and High-Performance Liquid Chromatography (HPLC) methods. The HPTLC analysis was used for the chromatographic fingerprints of polyphenols and for identifying linalool in the OATEs. The HPLC analysis found the significant content of rosmarinic acid (RA) (0.26%) in the OATEs. In conclusion, the developed OATEs can be considered as the new herbal medicinal product with significant sedative properties.Shanaida M.Golembiovska O.Jasicka-Misiak I.Oleshchuk O.Beley N.Kernychna I.Wieczorek P.P.Sciendoarticleamerican basilherbtincturesedative activitypolyphenolslinaloolchromatographic analysisTherapeutics. PharmacologyRM1-950ENEuropean Pharmaceutical Journal, Vol 68, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	american basil herb tincture sedative activity polyphenols linalool chromatographic analysis Therapeutics. Pharmacology RM1-950
spellingShingle	american basil herb tincture sedative activity polyphenols linalool chromatographic analysis Therapeutics. Pharmacology RM1-950 Shanaida M. Golembiovska O. Jasicka-Misiak I. Oleshchuk O. Beley N. Kernychna I. Wieczorek P.P. Sedative Effect and Standardization Parameters of Herbal Medicinal Product Obtained from the Ocimum americanum L. Herb
description	Sedative phytomedications continue to play an important role in the management of a considerable amount of anxiety symptoms because of the various side effects of synthetic sedatives and tranquilizers. However, developing new herbal drugs needs their appropriate quality control according to the relevant requirements. The aim of the study was to determine the sedative properties of the tinctures obtained from the American basil (Ocimum americanum L., Lamiaceae Martinov family) herb and to develop the standardization parameters for the promising herbal medicinal product. The open field test was used to evaluate the sedative effect of the prepared tinctures: (1) with the added of O. americanum essential oil (OATEs) and (2) without adding O. americanum essential oil (OAT). The standardization parameters for the OATEs were developed using validated High-Performance Thin Layer Chromatography (HPTLC) and High-Performance Liquid Chromatography (HPLC) methods. The HPTLC analysis was used for the chromatographic fingerprints of polyphenols and for identifying linalool in the OATEs. The HPLC analysis found the significant content of rosmarinic acid (RA) (0.26%) in the OATEs. In conclusion, the developed OATEs can be considered as the new herbal medicinal product with significant sedative properties.
format	article
author	Shanaida M. Golembiovska O. Jasicka-Misiak I. Oleshchuk O. Beley N. Kernychna I. Wieczorek P.P.
author_facet	Shanaida M. Golembiovska O. Jasicka-Misiak I. Oleshchuk O. Beley N. Kernychna I. Wieczorek P.P.
author_sort	Shanaida M.
title	Sedative Effect and Standardization Parameters of Herbal Medicinal Product Obtained from the Ocimum americanum L. Herb
title_short	Sedative Effect and Standardization Parameters of Herbal Medicinal Product Obtained from the Ocimum americanum L. Herb
title_full	Sedative Effect and Standardization Parameters of Herbal Medicinal Product Obtained from the Ocimum americanum L. Herb
title_fullStr	Sedative Effect and Standardization Parameters of Herbal Medicinal Product Obtained from the Ocimum americanum L. Herb
title_full_unstemmed	Sedative Effect and Standardization Parameters of Herbal Medicinal Product Obtained from the Ocimum americanum L. Herb
title_sort	sedative effect and standardization parameters of herbal medicinal product obtained from the ocimum americanum l. herb
publisher	Sciendo
publishDate	2021
url	https://doaj.org/article/2778697a75f04732a0719398dbee5228
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Sedative Effect and Standardization Parameters of Herbal Medicinal Product Obtained from the Ocimum americanum L. Herb

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