Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies

The bone microenvironment may alter therapeutic responses of disseminated breast cancer cells. Here the authors establish anex vivobone metastasis model, termed BICA, to delineate the effects of bone microenvironment and to rapidly discover anti-metastasis drugs.

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Autores principales:	Hai Wang, Lin Tian, Amit Goldstein, Jun Liu, Hin-Ching Lo, Kuanwei Sheng, Thomas Welte, Stephen T.C. Wong, Zbigniew Gugala, Fabio Stossi, Chenghang Zong, Zonghai Li, Michael A. Mancini, Xiang H.-F. Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/277b6262d22942908dfbeb83711138c3
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spelling	oai:doaj.org-article:277b6262d22942908dfbeb83711138c32021-12-02T14:42:08ZBone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies10.1038/ncomms150452041-1723https://doaj.org/article/277b6262d22942908dfbeb83711138c32017-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms15045https://doaj.org/toc/2041-1723The bone microenvironment may alter therapeutic responses of disseminated breast cancer cells. Here the authors establish anex vivobone metastasis model, termed BICA, to delineate the effects of bone microenvironment and to rapidly discover anti-metastasis drugs.Hai WangLin TianAmit GoldsteinJun LiuHin-Ching LoKuanwei ShengThomas WelteStephen T.C. WongZbigniew GugalaFabio StossiChenghang ZongZonghai LiMichael A. ManciniXiang H.-F. ZhangNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hai Wang Lin Tian Amit Goldstein Jun Liu Hin-Ching Lo Kuanwei Sheng Thomas Welte Stephen T.C. Wong Zbigniew Gugala Fabio Stossi Chenghang Zong Zonghai Li Michael A. Mancini Xiang H.-F. Zhang Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies
description	The bone microenvironment may alter therapeutic responses of disseminated breast cancer cells. Here the authors establish anex vivobone metastasis model, termed BICA, to delineate the effects of bone microenvironment and to rapidly discover anti-metastasis drugs.
format	article
author	Hai Wang Lin Tian Amit Goldstein Jun Liu Hin-Ching Lo Kuanwei Sheng Thomas Welte Stephen T.C. Wong Zbigniew Gugala Fabio Stossi Chenghang Zong Zonghai Li Michael A. Mancini Xiang H.-F. Zhang
author_facet	Hai Wang Lin Tian Amit Goldstein Jun Liu Hin-Ching Lo Kuanwei Sheng Thomas Welte Stephen T.C. Wong Zbigniew Gugala Fabio Stossi Chenghang Zong Zonghai Li Michael A. Mancini Xiang H.-F. Zhang
author_sort	Hai Wang
title	Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies
title_short	Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies
title_full	Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies
title_fullStr	Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies
title_full_unstemmed	Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies
title_sort	bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/277b6262d22942908dfbeb83711138c3
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Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies

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