Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment?

Antimicrobial blue light (aBL) treatment is considered low risk for the development of bacterial resistance and tolerance due to its multitarget mode of action. The aim of the current study was to demonstrate whether tolerance development occurs in Gram-negative bacteria. We evaluated the potential...

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Autores principales:	Aleksandra Rapacka-Zdonczyk, Agata Wozniak, Beata Kruszewska, Krzysztof Waleron, Mariusz Grinholc
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	antimicrobial blue light resistance tolerance <i>Escherichia coli</i> <i>Klebsiella pneumoniae</i> <i>Pseudomonas aeruginosa</i> Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/277b9fb2658145eba85b9794167e0213
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spelling	oai:doaj.org-article:277b9fb2658145eba85b9794167e02132021-11-11T17:03:41ZCan Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment?10.3390/ijms2221115791422-00671661-6596https://doaj.org/article/277b9fb2658145eba85b9794167e02132021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11579https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Antimicrobial blue light (aBL) treatment is considered low risk for the development of bacterial resistance and tolerance due to its multitarget mode of action. The aim of the current study was to demonstrate whether tolerance development occurs in Gram-negative bacteria. We evaluated the potential of tolerance/resistance development in <i>Escherichia coli</i>, <i>Klebsiella pneumoniae</i>, and <i>Pseudomonas aeruginosa</i> and demonstrated that representative Gram-negative bacteria may develop tolerance to aBL. The observed adaption was a stable feature. Assays involving <i>E. coli</i> K-12 <i>tolC</i>-, <i>tolA-</i>, <i>umuD-</i>, and <i>recA</i>-deficient mutants revealed some possible mechanisms for aBL tolerance development.Aleksandra Rapacka-ZdonczykAgata WozniakBeata KruszewskaKrzysztof WaleronMariusz GrinholcMDPI AGarticleantimicrobial blue lightresistancetolerance<i>Escherichia coli</i><i>Klebsiella pneumoniae</i><i>Pseudomonas aeruginosa</i>Biology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11579, p 11579 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	antimicrobial blue light resistance tolerance <i>Escherichia coli</i> <i>Klebsiella pneumoniae</i> <i>Pseudomonas aeruginosa</i> Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	antimicrobial blue light resistance tolerance <i>Escherichia coli</i> <i>Klebsiella pneumoniae</i> <i>Pseudomonas aeruginosa</i> Biology (General) QH301-705.5 Chemistry QD1-999 Aleksandra Rapacka-Zdonczyk Agata Wozniak Beata Kruszewska Krzysztof Waleron Mariusz Grinholc Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment?
description	Antimicrobial blue light (aBL) treatment is considered low risk for the development of bacterial resistance and tolerance due to its multitarget mode of action. The aim of the current study was to demonstrate whether tolerance development occurs in Gram-negative bacteria. We evaluated the potential of tolerance/resistance development in <i>Escherichia coli</i>, <i>Klebsiella pneumoniae</i>, and <i>Pseudomonas aeruginosa</i> and demonstrated that representative Gram-negative bacteria may develop tolerance to aBL. The observed adaption was a stable feature. Assays involving <i>E. coli</i> K-12 <i>tolC</i>-, <i>tolA-</i>, <i>umuD-</i>, and <i>recA</i>-deficient mutants revealed some possible mechanisms for aBL tolerance development.
format	article
author	Aleksandra Rapacka-Zdonczyk Agata Wozniak Beata Kruszewska Krzysztof Waleron Mariusz Grinholc
author_facet	Aleksandra Rapacka-Zdonczyk Agata Wozniak Beata Kruszewska Krzysztof Waleron Mariusz Grinholc
author_sort	Aleksandra Rapacka-Zdonczyk
title	Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment?
title_short	Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment?
title_full	Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment?
title_fullStr	Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment?
title_full_unstemmed	Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment?
title_sort	can gram-negative bacteria develop resistance to antimicrobial blue light treatment?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/277b9fb2658145eba85b9794167e0213
work_keys_str_mv	AT aleksandrarapackazdonczyk cangramnegativebacteriadevelopresistancetoantimicrobialbluelighttreatment AT agatawozniak cangramnegativebacteriadevelopresistancetoantimicrobialbluelighttreatment AT beatakruszewska cangramnegativebacteriadevelopresistancetoantimicrobialbluelighttreatment AT krzysztofwaleron cangramnegativebacteriadevelopresistancetoantimicrobialbluelighttreatment AT mariuszgrinholc cangramnegativebacteriadevelopresistancetoantimicrobialbluelighttreatment
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Can Gram-Negative Bacteria Develop Resistance to Antimicrobial Blue Light Treatment?

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