Association Between the A118G Polymorphism of the OPRM1 Gene and Suicidal Depression in a Large Cohort of Outpatients with Depression
Benedicte Nobile,1,2 Emilie Olie,1– 3 Nicolas Ramoz,4 Jonathan Dubois,1,2 Sebastien Guillaume,1– 3 Philip Gorwood,4 Philippe Courtet1– 3 1Department of Emergency Psychiatry and Acute Care, CHU Montpellier, Montpellier, France; 2IGF, University of Montpellier, CNRS, INSERM, Montpellier, France; 3Fond...
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| Formato: | article |
| Lenguaje: | EN |
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Dove Medical Press
2021
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| Acceso en línea: | https://doaj.org/article/277bd3355c124d6c96ac0cdf19ccfc83 |
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| Sumario: | Benedicte Nobile,1,2 Emilie Olie,1– 3 Nicolas Ramoz,4 Jonathan Dubois,1,2 Sebastien Guillaume,1– 3 Philip Gorwood,4 Philippe Courtet1– 3 1Department of Emergency Psychiatry and Acute Care, CHU Montpellier, Montpellier, France; 2IGF, University of Montpellier, CNRS, INSERM, Montpellier, France; 3FondaMental Foundation, Créteil, France; 4Inserm UMRS1266, Institute of Psychiatry and Neuroscience of Paris, Paris, FranceCorrespondence: Benedicte Nobile Email benedicte.nobile@gmail.comBackground: Growing evidences suggest that depression with suicidal ideation (SI) could be a specific phenotype with its own characteristics. Moreover, opioid system deregulation might be implicated in suicidal behaviour (SB). The aim of this study was to determine whether the A118G polymorphism (rs1799971) in ORPM1 (the gene encoding opioid receptor mu 1) is associated with suicidal depression (ie, moderate to severe depression with SI) in a large cohort of outpatients with depression.Methods: GENESE is a large, prospective, naturalistic cohort of French adult outpatients with depression (DSM-IV criteria), treated and followed for 6 weeks. Depression severity was assessed with the Hospital Anxiety and Depression Scale (HADS), and SI with the suicidal item of the Montgomery–Åsberg Depression Rating Scale (MADRS-SI). From this cohort, patients with moderate or severe depression (HADS-D subscale score > 11) were selected and classified as without SI (MADRS-SI < 2), or with SI (MADRS-SI ≥ 2).Results: The AA/AG genotypes of the A118G polymorphism were significantly associated with suicidal depression in the non-adjusted (OR = 2.32, 95% CI = [1.28; 4.18]; p-value = 0.005) and in the adjusted models (OR = 2.54, 95% CI = [1.35; 4.78]; p-value = 0.004).Conclusion: Outpatients with depression harbouring the A allele are at higher risk of SI (and possibly SB) than those carrying the G allele. More studies are needed to better understand the link between this polymorphism and SB.Keywords: suicide, suicidal ideation, opioid system, A118G, OPRM1 |
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