Association Between the A118G Polymorphism of the OPRM1 Gene and Suicidal Depression in a Large Cohort of Outpatients with Depression

Benedicte Nobile,1,2 Emilie Olie,1– 3 Nicolas Ramoz,4 Jonathan Dubois,1,2 Sebastien Guillaume,1– 3 Philip Gorwood,4 Philippe Courtet1– 3 1Department of Emergency Psychiatry and Acute Care, CHU Montpellier, Montpellier, France; 2IGF, University of Montpellier, CNRS, INSERM, Montpellier, France; 3Fond...

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Autores principales:	Nobile B, Olie E, Ramoz N, Dubois J, Guillaume S, Gorwood P, Courtet P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	suicide suicidal ideation opioid system a118g oprm1 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/277bd3355c124d6c96ac0cdf19ccfc83
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spelling	oai:doaj.org-article:277bd3355c124d6c96ac0cdf19ccfc832021-12-02T17:15:59ZAssociation Between the A118G Polymorphism of the OPRM1 Gene and Suicidal Depression in a Large Cohort of Outpatients with Depression1178-2021https://doaj.org/article/277bd3355c124d6c96ac0cdf19ccfc832021-10-01T00:00:00Zhttps://www.dovepress.com/association-between-the-a118g-polymorphism-of-the-oprm1-gene-and-suici-peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Benedicte Nobile,1,2 Emilie Olie,1– 3 Nicolas Ramoz,4 Jonathan Dubois,1,2 Sebastien Guillaume,1– 3 Philip Gorwood,4 Philippe Courtet1– 3 1Department of Emergency Psychiatry and Acute Care, CHU Montpellier, Montpellier, France; 2IGF, University of Montpellier, CNRS, INSERM, Montpellier, France; 3FondaMental Foundation, Créteil, France; 4Inserm UMRS1266, Institute of Psychiatry and Neuroscience of Paris, Paris, FranceCorrespondence: Benedicte Nobile Email benedicte.nobile@gmail.comBackground: Growing evidences suggest that depression with suicidal ideation (SI) could be a specific phenotype with its own characteristics. Moreover, opioid system deregulation might be implicated in suicidal behaviour (SB). The aim of this study was to determine whether the A118G polymorphism (rs1799971) in ORPM1 (the gene encoding opioid receptor mu 1) is associated with suicidal depression (ie, moderate to severe depression with SI) in a large cohort of outpatients with depression.Methods: GENESE is a large, prospective, naturalistic cohort of French adult outpatients with depression (DSM-IV criteria), treated and followed for 6 weeks. Depression severity was assessed with the Hospital Anxiety and Depression Scale (HADS), and SI with the suicidal item of the Montgomery–Åsberg Depression Rating Scale (MADRS-SI). From this cohort, patients with moderate or severe depression (HADS-D subscale score > 11) were selected and classified as without SI (MADRS-SI < 2), or with SI (MADRS-SI ≥ 2).Results: The AA/AG genotypes of the A118G polymorphism were significantly associated with suicidal depression in the non-adjusted (OR = 2.32, 95% CI = [1.28; 4.18]; p-value = 0.005) and in the adjusted models (OR = 2.54, 95% CI = [1.35; 4.78]; p-value = 0.004).Conclusion: Outpatients with depression harbouring the A allele are at higher risk of SI (and possibly SB) than those carrying the G allele. More studies are needed to better understand the link between this polymorphism and SB.Keywords: suicide, suicidal ideation, opioid system, A118G, OPRM1Nobile BOlie ERamoz NDubois JGuillaume SGorwood PCourtet PDove Medical Pressarticlesuicidesuicidal ideationopioid systema118goprm1Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 3109-3118 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	suicide suicidal ideation opioid system a118g oprm1 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	suicide suicidal ideation opioid system a118g oprm1 Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Nobile B Olie E Ramoz N Dubois J Guillaume S Gorwood P Courtet P Association Between the A118G Polymorphism of the OPRM1 Gene and Suicidal Depression in a Large Cohort of Outpatients with Depression
description	Benedicte Nobile,1,2 Emilie Olie,1– 3 Nicolas Ramoz,4 Jonathan Dubois,1,2 Sebastien Guillaume,1– 3 Philip Gorwood,4 Philippe Courtet1– 3 1Department of Emergency Psychiatry and Acute Care, CHU Montpellier, Montpellier, France; 2IGF, University of Montpellier, CNRS, INSERM, Montpellier, France; 3FondaMental Foundation, Créteil, France; 4Inserm UMRS1266, Institute of Psychiatry and Neuroscience of Paris, Paris, FranceCorrespondence: Benedicte Nobile Email benedicte.nobile@gmail.comBackground: Growing evidences suggest that depression with suicidal ideation (SI) could be a specific phenotype with its own characteristics. Moreover, opioid system deregulation might be implicated in suicidal behaviour (SB). The aim of this study was to determine whether the A118G polymorphism (rs1799971) in ORPM1 (the gene encoding opioid receptor mu 1) is associated with suicidal depression (ie, moderate to severe depression with SI) in a large cohort of outpatients with depression.Methods: GENESE is a large, prospective, naturalistic cohort of French adult outpatients with depression (DSM-IV criteria), treated and followed for 6 weeks. Depression severity was assessed with the Hospital Anxiety and Depression Scale (HADS), and SI with the suicidal item of the Montgomery–Åsberg Depression Rating Scale (MADRS-SI). From this cohort, patients with moderate or severe depression (HADS-D subscale score > 11) were selected and classified as without SI (MADRS-SI < 2), or with SI (MADRS-SI ≥ 2).Results: The AA/AG genotypes of the A118G polymorphism were significantly associated with suicidal depression in the non-adjusted (OR = 2.32, 95% CI = [1.28; 4.18]; p-value = 0.005) and in the adjusted models (OR = 2.54, 95% CI = [1.35; 4.78]; p-value = 0.004).Conclusion: Outpatients with depression harbouring the A allele are at higher risk of SI (and possibly SB) than those carrying the G allele. More studies are needed to better understand the link between this polymorphism and SB.Keywords: suicide, suicidal ideation, opioid system, A118G, OPRM1
format	article
author	Nobile B Olie E Ramoz N Dubois J Guillaume S Gorwood P Courtet P
author_facet	Nobile B Olie E Ramoz N Dubois J Guillaume S Gorwood P Courtet P
author_sort	Nobile B
title	Association Between the A118G Polymorphism of the OPRM1 Gene and Suicidal Depression in a Large Cohort of Outpatients with Depression
title_short	Association Between the A118G Polymorphism of the OPRM1 Gene and Suicidal Depression in a Large Cohort of Outpatients with Depression
title_full	Association Between the A118G Polymorphism of the OPRM1 Gene and Suicidal Depression in a Large Cohort of Outpatients with Depression
title_fullStr	Association Between the A118G Polymorphism of the OPRM1 Gene and Suicidal Depression in a Large Cohort of Outpatients with Depression
title_full_unstemmed	Association Between the A118G Polymorphism of the OPRM1 Gene and Suicidal Depression in a Large Cohort of Outpatients with Depression
title_sort	association between the a118g polymorphism of the oprm1 gene and suicidal depression in a large cohort of outpatients with depression
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/277bd3355c124d6c96ac0cdf19ccfc83
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Association Between the A118G Polymorphism of the OPRM1 Gene and Suicidal Depression in a Large Cohort of Outpatients with Depression

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