Culture positivity may correlate with long-term mortality in critically ill patients

Abstract Background The long-term outcome is currently a crucial issue in critical care, and we aim to address the association between culture positivity and long-term mortality in critically ill patients. Methods We used the 2015–2019 critical care database at Taichung Veterans General Hospital and...

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Autores principales:	Wei-Fan Ou, Li-Ting Wong, Chieh-Liang Wu, Wen-Cheng Chao
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Critical illness Long-term outcome Survival analysis Culture positivity Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/277e55be14244288a7ab7e74171e17ee
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spelling	oai:doaj.org-article:277e55be14244288a7ab7e74171e17ee2021-11-28T12:41:43ZCulture positivity may correlate with long-term mortality in critically ill patients10.1186/s12879-021-06898-81471-2334https://doaj.org/article/277e55be14244288a7ab7e74171e17ee2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12879-021-06898-8https://doaj.org/toc/1471-2334Abstract Background The long-term outcome is currently a crucial issue in critical care, and we aim to address the association between culture positivity and long-term mortality in critically ill patients. Methods We used the 2015–2019 critical care database at Taichung Veterans General Hospital and Taiwanese nationwide death registration files. Multivariable Cox proportional hazards regression model was conducted to determine hazard ratio (HR) and 95% confidence interval (CI). Results We enrolled 4488 critically ill patients, and the overall mortality was 55.2%. The follow-up duration among survivors was 2.2 ± 1.3 years. We found that 52.6% (2362/4488) of critically ill patients had at least one positive culture during the admission, and the number of patients with positive culture in the blood, respiratory tract and urinary tract were 593, 1831 and 831, respectively. We identified that a positive culture from blood (aHR 1.233; 95% CI 1.104–1.378), respiratory tract (aHR 1.217; 95% CI 1.109–1.364) and urinary tract (aHR 1.230; 95% CI 1.109–1.364) correlated with an increased risk of long-term mortality after adjusting relevant covariates. Conclusions Through linking two databases, we found that positive culture in the blood, respiratory tract and urinary tract during admission correlated with increased long-term overall mortality in critically ill patients.Wei-Fan OuLi-Ting WongChieh-Liang WuWen-Cheng ChaoBMCarticleCritical illnessLong-term outcomeSurvival analysisCulture positivityInfectious and parasitic diseasesRC109-216ENBMC Infectious Diseases, Vol 21, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Critical illness Long-term outcome Survival analysis Culture positivity Infectious and parasitic diseases RC109-216
spellingShingle	Critical illness Long-term outcome Survival analysis Culture positivity Infectious and parasitic diseases RC109-216 Wei-Fan Ou Li-Ting Wong Chieh-Liang Wu Wen-Cheng Chao Culture positivity may correlate with long-term mortality in critically ill patients
description	Abstract Background The long-term outcome is currently a crucial issue in critical care, and we aim to address the association between culture positivity and long-term mortality in critically ill patients. Methods We used the 2015–2019 critical care database at Taichung Veterans General Hospital and Taiwanese nationwide death registration files. Multivariable Cox proportional hazards regression model was conducted to determine hazard ratio (HR) and 95% confidence interval (CI). Results We enrolled 4488 critically ill patients, and the overall mortality was 55.2%. The follow-up duration among survivors was 2.2 ± 1.3 years. We found that 52.6% (2362/4488) of critically ill patients had at least one positive culture during the admission, and the number of patients with positive culture in the blood, respiratory tract and urinary tract were 593, 1831 and 831, respectively. We identified that a positive culture from blood (aHR 1.233; 95% CI 1.104–1.378), respiratory tract (aHR 1.217; 95% CI 1.109–1.364) and urinary tract (aHR 1.230; 95% CI 1.109–1.364) correlated with an increased risk of long-term mortality after adjusting relevant covariates. Conclusions Through linking two databases, we found that positive culture in the blood, respiratory tract and urinary tract during admission correlated with increased long-term overall mortality in critically ill patients.
format	article
author	Wei-Fan Ou Li-Ting Wong Chieh-Liang Wu Wen-Cheng Chao
author_facet	Wei-Fan Ou Li-Ting Wong Chieh-Liang Wu Wen-Cheng Chao
author_sort	Wei-Fan Ou
title	Culture positivity may correlate with long-term mortality in critically ill patients
title_short	Culture positivity may correlate with long-term mortality in critically ill patients
title_full	Culture positivity may correlate with long-term mortality in critically ill patients
title_fullStr	Culture positivity may correlate with long-term mortality in critically ill patients
title_full_unstemmed	Culture positivity may correlate with long-term mortality in critically ill patients
title_sort	culture positivity may correlate with long-term mortality in critically ill patients
publisher	BMC
publishDate	2021
url	https://doaj.org/article/277e55be14244288a7ab7e74171e17ee
work_keys_str_mv	AT weifanou culturepositivitymaycorrelatewithlongtermmortalityincriticallyillpatients AT litingwong culturepositivitymaycorrelatewithlongtermmortalityincriticallyillpatients AT chiehliangwu culturepositivitymaycorrelatewithlongtermmortalityincriticallyillpatients AT wenchengchao culturepositivitymaycorrelatewithlongtermmortalityincriticallyillpatients
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Culture positivity may correlate with long-term mortality in critically ill patients

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