HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis
The expression of telomerase catalytic subunit hTERT is frequently upregulated in many cancers. Here, the authors show HoxC5 and miR-615-3p can negatively regulate hTERT to impede tumorigenesis by targeting the newly evolved cis-regulatory genomic elements of hTERT.
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Nature Portfolio
2018
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oai:doaj.org-article:277e679dd3d749c1b6f4ca18ea1500632021-12-02T15:34:05ZHoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis10.1038/s41467-017-02601-12041-1723https://doaj.org/article/277e679dd3d749c1b6f4ca18ea1500632018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02601-1https://doaj.org/toc/2041-1723The expression of telomerase catalytic subunit hTERT is frequently upregulated in many cancers. Here, the authors show HoxC5 and miR-615-3p can negatively regulate hTERT to impede tumorigenesis by targeting the newly evolved cis-regulatory genomic elements of hTERT.TingDong YanWen Fong OoiAditi QamraAlice CheungDongLiang MaGopinath Meenakshi SundaramChang XuManjie XingLaiFong PoonJing WangYan Ping LohJess Hui Jie HoJoscelyn Jun Quan NgMuhammad Khairul RamleeLuay AswadSteve G. RozenSujoy GhoshFrederic A. BardPrabha SampathVinay TergaonkarJames O. J. DaviesJim R. HughesEyleen GohXuezhi BiMelissa Jane FullwoodPatrick TanShang LiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018) |
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DOAJ |
| language |
EN |
| topic |
Science Q |
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Science Q TingDong Yan Wen Fong Ooi Aditi Qamra Alice Cheung DongLiang Ma Gopinath Meenakshi Sundaram Chang Xu Manjie Xing LaiFong Poon Jing Wang Yan Ping Loh Jess Hui Jie Ho Joscelyn Jun Quan Ng Muhammad Khairul Ramlee Luay Aswad Steve G. Rozen Sujoy Ghosh Frederic A. Bard Prabha Sampath Vinay Tergaonkar James O. J. Davies Jim R. Hughes Eyleen Goh Xuezhi Bi Melissa Jane Fullwood Patrick Tan Shang Li HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis |
| description |
The expression of telomerase catalytic subunit hTERT is frequently upregulated in many cancers. Here, the authors show HoxC5 and miR-615-3p can negatively regulate hTERT to impede tumorigenesis by targeting the newly evolved cis-regulatory genomic elements of hTERT. |
| format |
article |
| author |
TingDong Yan Wen Fong Ooi Aditi Qamra Alice Cheung DongLiang Ma Gopinath Meenakshi Sundaram Chang Xu Manjie Xing LaiFong Poon Jing Wang Yan Ping Loh Jess Hui Jie Ho Joscelyn Jun Quan Ng Muhammad Khairul Ramlee Luay Aswad Steve G. Rozen Sujoy Ghosh Frederic A. Bard Prabha Sampath Vinay Tergaonkar James O. J. Davies Jim R. Hughes Eyleen Goh Xuezhi Bi Melissa Jane Fullwood Patrick Tan Shang Li |
| author_facet |
TingDong Yan Wen Fong Ooi Aditi Qamra Alice Cheung DongLiang Ma Gopinath Meenakshi Sundaram Chang Xu Manjie Xing LaiFong Poon Jing Wang Yan Ping Loh Jess Hui Jie Ho Joscelyn Jun Quan Ng Muhammad Khairul Ramlee Luay Aswad Steve G. Rozen Sujoy Ghosh Frederic A. Bard Prabha Sampath Vinay Tergaonkar James O. J. Davies Jim R. Hughes Eyleen Goh Xuezhi Bi Melissa Jane Fullwood Patrick Tan Shang Li |
| author_sort |
TingDong Yan |
| title |
HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis |
| title_short |
HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis |
| title_full |
HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis |
| title_fullStr |
HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis |
| title_full_unstemmed |
HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis |
| title_sort |
hoxc5 and mir-615-3p target newly evolved genomic regions to repress htert and inhibit tumorigenesis |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/277e679dd3d749c1b6f4ca18ea150063 |
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| _version_ |
1718386888025309184 |