Role and inhibition of GLI1 protein in cancer
Eloise Mastrangelo, Mario Milani CNR – Biophysics Institute, c/o Dipartimento di Bioscienze, Università degli Studi di Milano, Milano, Italy Abstract: GLI1 is a transcriptional regulator involved in the development of different types of cancer. GLI1 transcriptional activity is r...
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| Autores principales: | , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Dove Medical Press
2018
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/27805103872545978363f9c384ba49ea |
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| Sumario: | Eloise Mastrangelo, Mario Milani CNR – Biophysics Institute, c/o Dipartimento di Bioscienze, Università degli Studi di Milano, Milano, Italy Abstract: GLI1 is a transcriptional regulator involved in the development of different types of cancer. GLI1 transcriptional activity is regulated within the Hedgehog pathway (canonical activity), but can also be controlled independently (non-canonical activity) in the context of other signaling pathways. Experimental evidences show GLI1 involvement in both small- and non–small-cell lung cancers. Direct inhibition of the protein, in combination with other chemotherapeutic agents, represents a promising strategy for the treatment of different malignancies. Keywords: Hedgehog pathway, transcriptional regulator, lung cancer, inhibitors |
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