Role and inhibition of GLI1 protein in cancer

Eloise Mastrangelo, Mario Milani CNR – Biophysics Institute, c/o Dipartimento di Bioscienze, Università degli Studi di Milano, Milano, Italy Abstract: GLI1 is a transcriptional regulator involved in the development of different types of cancer. GLI1 transcriptional activity is r...

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Autores principales:	Mastrangelo E, Milani M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Hedgehog pathway transcriptional regulator lung cancer inhibitors Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/27805103872545978363f9c384ba49ea
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spelling	oai:doaj.org-article:27805103872545978363f9c384ba49ea2021-12-02T05:10:51ZRole and inhibition of GLI1 protein in cancer1179-2728https://doaj.org/article/27805103872545978363f9c384ba49ea2018-03-01T00:00:00Zhttps://www.dovepress.com/role-and-inhibition-of-gli1-protein-in-cancer-peer-reviewed-article-LCTThttps://doaj.org/toc/1179-2728Eloise Mastrangelo, Mario Milani CNR – Biophysics Institute, c/o Dipartimento di Bioscienze, Università degli Studi di Milano, Milano, Italy Abstract: GLI1 is a transcriptional regulator involved in the development of different types of cancer. GLI1 transcriptional activity is regulated within the Hedgehog pathway (canonical activity), but can also be controlled independently (non-canonical activity) in the context of other signaling pathways. Experimental evidences show GLI1 involvement in both small- and non–small-cell lung cancers. Direct inhibition of the protein, in combination with other chemotherapeutic agents, represents a promising strategy for the treatment of different malignancies. Keywords: Hedgehog pathway, transcriptional regulator, lung cancer, inhibitorsMastrangelo EMilani MDove Medical PressarticleHedgehog pathwaytranscriptional regulatorlung cancerinhibitorsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENLung Cancer: Targets and Therapy, Vol Volume 9, Pp 35-43 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Hedgehog pathway transcriptional regulator lung cancer inhibitors Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Hedgehog pathway transcriptional regulator lung cancer inhibitors Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Mastrangelo E Milani M Role and inhibition of GLI1 protein in cancer
description	Eloise Mastrangelo, Mario Milani CNR – Biophysics Institute, c/o Dipartimento di Bioscienze, Università degli Studi di Milano, Milano, Italy Abstract: GLI1 is a transcriptional regulator involved in the development of different types of cancer. GLI1 transcriptional activity is regulated within the Hedgehog pathway (canonical activity), but can also be controlled independently (non-canonical activity) in the context of other signaling pathways. Experimental evidences show GLI1 involvement in both small- and non–small-cell lung cancers. Direct inhibition of the protein, in combination with other chemotherapeutic agents, represents a promising strategy for the treatment of different malignancies. Keywords: Hedgehog pathway, transcriptional regulator, lung cancer, inhibitors
format	article
author	Mastrangelo E Milani M
author_facet	Mastrangelo E Milani M
author_sort	Mastrangelo E
title	Role and inhibition of GLI1 protein in cancer
title_short	Role and inhibition of GLI1 protein in cancer
title_full	Role and inhibition of GLI1 protein in cancer
title_fullStr	Role and inhibition of GLI1 protein in cancer
title_full_unstemmed	Role and inhibition of GLI1 protein in cancer
title_sort	role and inhibition of gli1 protein in cancer
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/27805103872545978363f9c384ba49ea
work_keys_str_mv	AT mastrangeloe roleandinhibitionofgli1proteinincancer AT milanim roleandinhibitionofgli1proteinincancer
_version_	1718400521097707520

Role and inhibition of GLI1 protein in cancer

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