Interventions on Metabolism: Making Antibiotic-Susceptible Bacteria

ABSTRACT Antibiotics act on bacterial metabolism, and antibiotic resistance involves changes in this metabolism. Interventions on metabolism with drugs might therefore modify drug susceptibility and drug resistance. In their recent article, Martin Vestergaard et al. (mBio 8:e01114-17, 2017, https://...

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Autores principales:	Fernando Baquero, José-Luis Martínez
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2017
Materias:	antibiotic resistance bacterial metabolism polymyxins recovering susceptibility Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/278551a7959f4f019b5cf07871f6702e
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spelling	oai:doaj.org-article:278551a7959f4f019b5cf07871f6702e2021-11-15T15:51:56ZInterventions on Metabolism: Making Antibiotic-Susceptible Bacteria10.1128/mBio.01950-172150-7511https://doaj.org/article/278551a7959f4f019b5cf07871f6702e2017-12-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01950-17https://doaj.org/toc/2150-7511ABSTRACT Antibiotics act on bacterial metabolism, and antibiotic resistance involves changes in this metabolism. Interventions on metabolism with drugs might therefore modify drug susceptibility and drug resistance. In their recent article, Martin Vestergaard et al. (mBio 8:e01114-17, 2017, https://doi.org/10.1128/mBio.01114-17 ) illustrate the possibility of converting intrinsically resistant bacteria into susceptible ones. They reported that inhibition of a central metabolic enzyme, ATP synthase, allows otherwise ineffective polymyxin antibiotics to act on Staphylococcus aureus. The study of the intrinsic resistome of bacterial pathogens has shown that several metabolic genes, including multigene transcriptional regulators, contribute to antibiotic resistance. In some cases, these genes only marginally increase antibiotic resistance, but reduced levels of susceptibility might be critical in the evolution or resistance under low antibiotic concentrations or in the clinical response of highly resistant bacteria. Drug interventions on bacterial metabolism might constitute a critical adjuvant therapy in combination with antibiotics to ensure susceptibility of pathogens with intrinsic or acquired antimicrobial resistance.Fernando BaqueroJosé-Luis MartínezAmerican Society for Microbiologyarticleantibiotic resistancebacterial metabolismpolymyxinsrecovering susceptibilityMicrobiologyQR1-502ENmBio, Vol 8, Iss 6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	antibiotic resistance bacterial metabolism polymyxins recovering susceptibility Microbiology QR1-502
spellingShingle	antibiotic resistance bacterial metabolism polymyxins recovering susceptibility Microbiology QR1-502 Fernando Baquero José-Luis Martínez Interventions on Metabolism: Making Antibiotic-Susceptible Bacteria
description	ABSTRACT Antibiotics act on bacterial metabolism, and antibiotic resistance involves changes in this metabolism. Interventions on metabolism with drugs might therefore modify drug susceptibility and drug resistance. In their recent article, Martin Vestergaard et al. (mBio 8:e01114-17, 2017, https://doi.org/10.1128/mBio.01114-17 ) illustrate the possibility of converting intrinsically resistant bacteria into susceptible ones. They reported that inhibition of a central metabolic enzyme, ATP synthase, allows otherwise ineffective polymyxin antibiotics to act on Staphylococcus aureus. The study of the intrinsic resistome of bacterial pathogens has shown that several metabolic genes, including multigene transcriptional regulators, contribute to antibiotic resistance. In some cases, these genes only marginally increase antibiotic resistance, but reduced levels of susceptibility might be critical in the evolution or resistance under low antibiotic concentrations or in the clinical response of highly resistant bacteria. Drug interventions on bacterial metabolism might constitute a critical adjuvant therapy in combination with antibiotics to ensure susceptibility of pathogens with intrinsic or acquired antimicrobial resistance.
format	article
author	Fernando Baquero José-Luis Martínez
author_facet	Fernando Baquero José-Luis Martínez
author_sort	Fernando Baquero
title	Interventions on Metabolism: Making Antibiotic-Susceptible Bacteria
title_short	Interventions on Metabolism: Making Antibiotic-Susceptible Bacteria
title_full	Interventions on Metabolism: Making Antibiotic-Susceptible Bacteria
title_fullStr	Interventions on Metabolism: Making Antibiotic-Susceptible Bacteria
title_full_unstemmed	Interventions on Metabolism: Making Antibiotic-Susceptible Bacteria
title_sort	interventions on metabolism: making antibiotic-susceptible bacteria
publisher	American Society for Microbiology
publishDate	2017
url	https://doaj.org/article/278551a7959f4f019b5cf07871f6702e
work_keys_str_mv	AT fernandobaquero interventionsonmetabolismmakingantibioticsusceptiblebacteria AT joseluismartinez interventionsonmetabolismmakingantibioticsusceptiblebacteria
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Interventions on Metabolism: Making Antibiotic-Susceptible Bacteria

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