The electrochemical reaction controlled optical response of cholestrol oxidase (COx) conjugated CdSe/ZnS quantum dots

Abstract This paper reports the enhanced performance of cholesterol oxidase (COx) conjugated CdSe/ZnS quantum dots (QDs) by using water-soluble mercaptoacitic acid (MAA) as linker. The functionalized MAA-CdSe/ZnS QDs conjugated in four different dilutions of cholesterol oxidase significantly affecte...

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Autores principales:	Humaira Arshad, Madeeha Chaudhry, Shahid Mehmood, Ayesha Farooq, Minqiang Wang, A. S. Bhatti
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/2788072febb340d2ae730741f2f089bd
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spelling	oai:doaj.org-article:2788072febb340d2ae730741f2f089bd2021-12-02T15:10:30ZThe electrochemical reaction controlled optical response of cholestrol oxidase (COx) conjugated CdSe/ZnS quantum dots10.1038/s41598-020-77499-92045-2322https://doaj.org/article/2788072febb340d2ae730741f2f089bd2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77499-9https://doaj.org/toc/2045-2322Abstract This paper reports the enhanced performance of cholesterol oxidase (COx) conjugated CdSe/ZnS quantum dots (QDs) by using water-soluble mercaptoacitic acid (MAA) as linker. The functionalized MAA-CdSe/ZnS QDs conjugated in four different dilutions of cholesterol oxidase significantly affected QDs photoluminescence intensities, which affected the process of charge transfer from QDs to MAA. The conjugation of COx to MAA-QDs in increased dilutions resulted in the regain of PL intensities, which were attributed to the passivation of MAA HOMO/LUMO states. The electrochemical impedance spectroscopy and cyclic voltammetry of the conjugated QDs were performed to get study the charge transfer mechanism. The 1:1000 diluted COx conjugated MAA-CdSe/ZnS QDs was found to have the lowest charge transfer resistance of 228 Ω, the highest diffusion (~ 1.39 × 10–13 cm2/s) and charge transfer rates (~ 4.5 × 10–6 s−1) between the electrode and the redox species. The current study demonstrated the sensitivity of electrochemical and optical based detection on the alkaline.Humaira ArshadMadeeha ChaudhryShahid MehmoodAyesha FarooqMinqiang WangA. S. BhattiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Humaira Arshad Madeeha Chaudhry Shahid Mehmood Ayesha Farooq Minqiang Wang A. S. Bhatti The electrochemical reaction controlled optical response of cholestrol oxidase (COx) conjugated CdSe/ZnS quantum dots
description	Abstract This paper reports the enhanced performance of cholesterol oxidase (COx) conjugated CdSe/ZnS quantum dots (QDs) by using water-soluble mercaptoacitic acid (MAA) as linker. The functionalized MAA-CdSe/ZnS QDs conjugated in four different dilutions of cholesterol oxidase significantly affected QDs photoluminescence intensities, which affected the process of charge transfer from QDs to MAA. The conjugation of COx to MAA-QDs in increased dilutions resulted in the regain of PL intensities, which were attributed to the passivation of MAA HOMO/LUMO states. The electrochemical impedance spectroscopy and cyclic voltammetry of the conjugated QDs were performed to get study the charge transfer mechanism. The 1:1000 diluted COx conjugated MAA-CdSe/ZnS QDs was found to have the lowest charge transfer resistance of 228 Ω, the highest diffusion (~ 1.39 × 10–13 cm2/s) and charge transfer rates (~ 4.5 × 10–6 s−1) between the electrode and the redox species. The current study demonstrated the sensitivity of electrochemical and optical based detection on the alkaline.
format	article
author	Humaira Arshad Madeeha Chaudhry Shahid Mehmood Ayesha Farooq Minqiang Wang A. S. Bhatti
author_facet	Humaira Arshad Madeeha Chaudhry Shahid Mehmood Ayesha Farooq Minqiang Wang A. S. Bhatti
author_sort	Humaira Arshad
title	The electrochemical reaction controlled optical response of cholestrol oxidase (COx) conjugated CdSe/ZnS quantum dots
title_short	The electrochemical reaction controlled optical response of cholestrol oxidase (COx) conjugated CdSe/ZnS quantum dots
title_full	The electrochemical reaction controlled optical response of cholestrol oxidase (COx) conjugated CdSe/ZnS quantum dots
title_fullStr	The electrochemical reaction controlled optical response of cholestrol oxidase (COx) conjugated CdSe/ZnS quantum dots
title_full_unstemmed	The electrochemical reaction controlled optical response of cholestrol oxidase (COx) conjugated CdSe/ZnS quantum dots
title_sort	electrochemical reaction controlled optical response of cholestrol oxidase (cox) conjugated cdse/zns quantum dots
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/2788072febb340d2ae730741f2f089bd
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The electrochemical reaction controlled optical response of cholestrol oxidase (COx) conjugated CdSe/ZnS quantum dots

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