National profile and treatment outcomes of patients with extrapulmonary tuberculosis in Bénin.

<h4>Background</h4>In sub-Saharan Africa, there is a dearth of published literature on extrapulmonary tuberculosis (EPTB).<h4>Objective</h4>To describe demographic, diagnostic and HIV-status characteristics of patients with EPTB in Bénin, their treatment outcomes, and among t...

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Autores principales:	Serge Ade, Anthony D Harries, Arnaud Trébucq, Gabriel Ade, Gildas Agodokpessi, Christine Adjonou, Sophie Azon, Sévérin Anagonou
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/278c052d62c340ddb24afa27d5010d89
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spelling	oai:doaj.org-article:278c052d62c340ddb24afa27d5010d892021-11-18T08:22:04ZNational profile and treatment outcomes of patients with extrapulmonary tuberculosis in Bénin.1932-620310.1371/journal.pone.0095603https://doaj.org/article/278c052d62c340ddb24afa27d5010d892014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24755603/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>In sub-Saharan Africa, there is a dearth of published literature on extrapulmonary tuberculosis (EPTB).<h4>Objective</h4>To describe demographic, diagnostic and HIV-status characteristics of patients with EPTB in Bénin, their treatment outcomes, and among those who completed their treatment in the Centre National Hospitalier de Pneumo-Phtisiologie (CNHP-P), the proportion whose bodyweight increased during treatment.<h4>Material and findings</h4>This was a retrospective cohort study with comparisons made between EPTB and new smear-positive pulmonary tuberculosis (NPTB) patients diagnosed in the country from January to December 2011. There were 383 EPTB patients (9% of all TB cases) with a mean age of 35 years, male/female ratio of 1.3 and important regional variation. There were significantly more females (p = 0.001), children <15 years (p<0.001) and HIV-positive patients (p = 0.005) with EPTB compared with NPTB. Pleural effusion, spinal and lymph node tuberculosis accounted for 66% of all EPTB. Children <15 years represented 16% of cases, with lymph node disease being most common among them (p<0.001). Of 130 EPTB patients registered in CNHP-P, 7% had a confirmed bacteriological/histological diagnosis. There were 331 (86%) patients who successfully completed treatment. More patients with EPTB were lost-to-follow-up compared with NPTB (p<0.001) with all these patients from one region. The best treatment completion rates were in children <15 years (OR:3.5, 95%CI:1.0-14.8) while patients with pleural effusion and ascites had the worst outcomes. Of 72 HIV-coinfected patients, 88% were on antiretroviral therapy (ART). HIV-positive status was associated with poor outcomes while those on ART fared better. In the CNHP-P, more than 80% who completed their treatment showed an increase in bodyweight and this was more evident in HIV-positive compared with HIV-negative patients (p = 0.03).<h4>Conclusion</h4>Patients with EPTB generally do well in Bénin, although the TB Programme would benefit through more attention to accurate diagnosis and earlier start of ART in HIV-infected patients.Serge AdeAnthony D HarriesArnaud TrébucqGabriel AdeGildas AgodokpessiChristine AdjonouSophie AzonSévérin AnagonouPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 4, p e95603 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Serge Ade Anthony D Harries Arnaud Trébucq Gabriel Ade Gildas Agodokpessi Christine Adjonou Sophie Azon Sévérin Anagonou National profile and treatment outcomes of patients with extrapulmonary tuberculosis in Bénin.
description	<h4>Background</h4>In sub-Saharan Africa, there is a dearth of published literature on extrapulmonary tuberculosis (EPTB).<h4>Objective</h4>To describe demographic, diagnostic and HIV-status characteristics of patients with EPTB in Bénin, their treatment outcomes, and among those who completed their treatment in the Centre National Hospitalier de Pneumo-Phtisiologie (CNHP-P), the proportion whose bodyweight increased during treatment.<h4>Material and findings</h4>This was a retrospective cohort study with comparisons made between EPTB and new smear-positive pulmonary tuberculosis (NPTB) patients diagnosed in the country from January to December 2011. There were 383 EPTB patients (9% of all TB cases) with a mean age of 35 years, male/female ratio of 1.3 and important regional variation. There were significantly more females (p = 0.001), children <15 years (p<0.001) and HIV-positive patients (p = 0.005) with EPTB compared with NPTB. Pleural effusion, spinal and lymph node tuberculosis accounted for 66% of all EPTB. Children <15 years represented 16% of cases, with lymph node disease being most common among them (p<0.001). Of 130 EPTB patients registered in CNHP-P, 7% had a confirmed bacteriological/histological diagnosis. There were 331 (86%) patients who successfully completed treatment. More patients with EPTB were lost-to-follow-up compared with NPTB (p<0.001) with all these patients from one region. The best treatment completion rates were in children <15 years (OR:3.5, 95%CI:1.0-14.8) while patients with pleural effusion and ascites had the worst outcomes. Of 72 HIV-coinfected patients, 88% were on antiretroviral therapy (ART). HIV-positive status was associated with poor outcomes while those on ART fared better. In the CNHP-P, more than 80% who completed their treatment showed an increase in bodyweight and this was more evident in HIV-positive compared with HIV-negative patients (p = 0.03).<h4>Conclusion</h4>Patients with EPTB generally do well in Bénin, although the TB Programme would benefit through more attention to accurate diagnosis and earlier start of ART in HIV-infected patients.
format	article
author	Serge Ade Anthony D Harries Arnaud Trébucq Gabriel Ade Gildas Agodokpessi Christine Adjonou Sophie Azon Sévérin Anagonou
author_facet	Serge Ade Anthony D Harries Arnaud Trébucq Gabriel Ade Gildas Agodokpessi Christine Adjonou Sophie Azon Sévérin Anagonou
author_sort	Serge Ade
title	National profile and treatment outcomes of patients with extrapulmonary tuberculosis in Bénin.
title_short	National profile and treatment outcomes of patients with extrapulmonary tuberculosis in Bénin.
title_full	National profile and treatment outcomes of patients with extrapulmonary tuberculosis in Bénin.
title_fullStr	National profile and treatment outcomes of patients with extrapulmonary tuberculosis in Bénin.
title_full_unstemmed	National profile and treatment outcomes of patients with extrapulmonary tuberculosis in Bénin.
title_sort	national profile and treatment outcomes of patients with extrapulmonary tuberculosis in bénin.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/278c052d62c340ddb24afa27d5010d89
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National profile and treatment outcomes of patients with extrapulmonary tuberculosis in Bénin.

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