Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis

Chitinase-3-like-1 (Chi3l1) has been involved in inflammation and pulmonary metastasis. Here the authors show that Chi3l1 inhibits the T cell response by negatively regulating their activation and that, in a mouse model of melanoma, T cell-targeted silencing of Chi3l1 results in reduced lung metasta...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Do-Hyun Kim, Hong-Jai Park, Sangho Lim, Ja-Hyun Koo, Hong-Gyun Lee, Jin Ouk Choi, Ji Hoon Oh, Sang-Jun Ha, Min-Jong Kang, Chang-Min Lee, Chun Geun Lee, Jack A. Elias, Je-Min Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/278c64fb54e544eda2674e6aee00955b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:278c64fb54e544eda2674e6aee00955b
record_format	dspace
spelling	oai:doaj.org-article:278c64fb54e544eda2674e6aee00955b2021-12-02T14:41:06ZRegulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis10.1038/s41467-017-02731-62041-1723https://doaj.org/article/278c64fb54e544eda2674e6aee00955b2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02731-6https://doaj.org/toc/2041-1723Chitinase-3-like-1 (Chi3l1) has been involved in inflammation and pulmonary metastasis. Here the authors show that Chi3l1 inhibits the T cell response by negatively regulating their activation and that, in a mouse model of melanoma, T cell-targeted silencing of Chi3l1 results in reduced lung metastasis.Do-Hyun KimHong-Jai ParkSangho LimJa-Hyun KooHong-Gyun LeeJin Ouk ChoiJi Hoon OhSang-Jun HaMin-Jong KangChang-Min LeeChun Geun LeeJack A. EliasJe-Min ChoiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Do-Hyun Kim Hong-Jai Park Sangho Lim Ja-Hyun Koo Hong-Gyun Lee Jin Ouk Choi Ji Hoon Oh Sang-Jun Ha Min-Jong Kang Chang-Min Lee Chun Geun Lee Jack A. Elias Je-Min Choi Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis
description	Chitinase-3-like-1 (Chi3l1) has been involved in inflammation and pulmonary metastasis. Here the authors show that Chi3l1 inhibits the T cell response by negatively regulating their activation and that, in a mouse model of melanoma, T cell-targeted silencing of Chi3l1 results in reduced lung metastasis.
format	article
author	Do-Hyun Kim Hong-Jai Park Sangho Lim Ja-Hyun Koo Hong-Gyun Lee Jin Ouk Choi Ji Hoon Oh Sang-Jun Ha Min-Jong Kang Chang-Min Lee Chun Geun Lee Jack A. Elias Je-Min Choi
author_facet	Do-Hyun Kim Hong-Jai Park Sangho Lim Ja-Hyun Koo Hong-Gyun Lee Jin Ouk Choi Ji Hoon Oh Sang-Jun Ha Min-Jong Kang Chang-Min Lee Chun Geun Lee Jack A. Elias Je-Min Choi
author_sort	Do-Hyun Kim
title	Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis
title_short	Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis
title_full	Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis
title_fullStr	Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis
title_full_unstemmed	Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis
title_sort	regulation of chitinase-3-like-1 in t cell elicits th1 and cytotoxic responses to inhibit lung metastasis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/278c64fb54e544eda2674e6aee00955b
work_keys_str_mv	AT dohyunkim regulationofchitinase3like1intcellelicitsth1andcytotoxicresponsestoinhibitlungmetastasis AT hongjaipark regulationofchitinase3like1intcellelicitsth1andcytotoxicresponsestoinhibitlungmetastasis AT sangholim regulationofchitinase3like1intcellelicitsth1andcytotoxicresponsestoinhibitlungmetastasis AT jahyunkoo regulationofchitinase3like1intcellelicitsth1andcytotoxicresponsestoinhibitlungmetastasis AT honggyunlee regulationofchitinase3like1intcellelicitsth1andcytotoxicresponsestoinhibitlungmetastasis AT jinoukchoi regulationofchitinase3like1intcellelicitsth1andcytotoxicresponsestoinhibitlungmetastasis AT jihoonoh regulationofchitinase3like1intcellelicitsth1andcytotoxicresponsestoinhibitlungmetastasis AT sangjunha regulationofchitinase3like1intcellelicitsth1andcytotoxicresponsestoinhibitlungmetastasis AT minjongkang regulationofchitinase3like1intcellelicitsth1andcytotoxicresponsestoinhibitlungmetastasis AT changminlee regulationofchitinase3like1intcellelicitsth1andcytotoxicresponsestoinhibitlungmetastasis AT chungeunlee regulationofchitinase3like1intcellelicitsth1andcytotoxicresponsestoinhibitlungmetastasis AT jackaelias regulationofchitinase3like1intcellelicitsth1andcytotoxicresponsestoinhibitlungmetastasis AT jeminchoi regulationofchitinase3like1intcellelicitsth1andcytotoxicresponsestoinhibitlungmetastasis
_version_	1718389979704459264

Regulation of chitinase-3-like-1 in T cell elicits Th1 and cytotoxic responses to inhibit lung metastasis

Ejemplares similares