A case of HPV-53-related cervical cancer in an elderly patient

Marusya Lieveld,1 Elizaveta Padalko,2,3 Marleen Praet,4 Davy Vanden Broeck1 1Department of Uro/gynaecology, Ghent University Hospital, Ghent, Belgium; 2Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent, Belgium; 3School of Life Sciences, Hasselt Univers...

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Autores principales:	Lieveld M, Padalko E, Praet M, Vanden Broeck D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	HPV53 HRM cervical cancer Anyplex II HPV 28 Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/279245116601433cb6a5936270b50c78
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spelling	oai:doaj.org-article:279245116601433cb6a5936270b50c782021-12-02T04:54:03ZA case of HPV-53-related cervical cancer in an elderly patient1178-1998https://doaj.org/article/279245116601433cb6a5936270b50c782014-11-01T00:00:00Zhttps://www.dovepress.com/a-case-of-hpv-53-related-cervical-cancer-in-an-elderly-patient-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Marusya Lieveld,1 Elizaveta Padalko,2,3 Marleen Praet,4 Davy Vanden Broeck1 1Department of Uro/gynaecology, Ghent University Hospital, Ghent, Belgium; 2Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent, Belgium; 3School of Life Sciences, Hasselt University, Diepenbeek, Belgium; 4N. Goormaghtigh Institute of Pathology, Ghent University Hospital, Ghent, BelgiumZappacosta et al1 recently published a case report concerning a human papillomavirus (HPV)-positive invasive cervical cancer in a 79-year-old women who had a history of normal Pap smears. In this article, Anyplex II HPV28 (Seegene) is used for HPV genotyping of formalin-fixed paraffin embedded (FFPE) tissue, liquid based cytology (LBC) specimens and urine samples. It is suggested that HPV53 is present exclusively in the cervical cancer cells, lymph node metastases, and atypical urinary cells of one single case while the surrounding CIN2+ tissue revealed ten different HPV strains. Unfortunately, the HPV genotype results for lymph nodes and urinary cells are not presented while these results underline the potential role of HPV53 in oncogenesis. Moreover, it is generally accepted that one lesion is caused by one HPV infection, detection of multiple HPV types thus indicates the presence of multiple infections,2 suggesting that this patient may have several lesions. Read the original article  Lieveld MPadalko EPraet MVanden Broeck DDove Medical PressarticleHPV53HRMcervical cancerAnyplex II HPV 28GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 9, Pp 1933-1938 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	HPV53 HRM cervical cancer Anyplex II HPV 28 Geriatrics RC952-954.6
spellingShingle	HPV53 HRM cervical cancer Anyplex II HPV 28 Geriatrics RC952-954.6 Lieveld M Padalko E Praet M Vanden Broeck D A case of HPV-53-related cervical cancer in an elderly patient
description	Marusya Lieveld,1 Elizaveta Padalko,2,3 Marleen Praet,4 Davy Vanden Broeck1 1Department of Uro/gynaecology, Ghent University Hospital, Ghent, Belgium; 2Department of Clinical Chemistry, Microbiology and Immunology, Ghent University Hospital, Ghent, Belgium; 3School of Life Sciences, Hasselt University, Diepenbeek, Belgium; 4N. Goormaghtigh Institute of Pathology, Ghent University Hospital, Ghent, BelgiumZappacosta et al1 recently published a case report concerning a human papillomavirus (HPV)-positive invasive cervical cancer in a 79-year-old women who had a history of normal Pap smears. In this article, Anyplex II HPV28 (Seegene) is used for HPV genotyping of formalin-fixed paraffin embedded (FFPE) tissue, liquid based cytology (LBC) specimens and urine samples. It is suggested that HPV53 is present exclusively in the cervical cancer cells, lymph node metastases, and atypical urinary cells of one single case while the surrounding CIN2+ tissue revealed ten different HPV strains. Unfortunately, the HPV genotype results for lymph nodes and urinary cells are not presented while these results underline the potential role of HPV53 in oncogenesis. Moreover, it is generally accepted that one lesion is caused by one HPV infection, detection of multiple HPV types thus indicates the presence of multiple infections,2 suggesting that this patient may have several lesions. Read the original article
format	article
author	Lieveld M Padalko E Praet M Vanden Broeck D
author_facet	Lieveld M Padalko E Praet M Vanden Broeck D
author_sort	Lieveld M
title	A case of HPV-53-related cervical cancer in an elderly patient
title_short	A case of HPV-53-related cervical cancer in an elderly patient
title_full	A case of HPV-53-related cervical cancer in an elderly patient
title_fullStr	A case of HPV-53-related cervical cancer in an elderly patient
title_full_unstemmed	A case of HPV-53-related cervical cancer in an elderly patient
title_sort	case of hpv-53-related cervical cancer in an elderly patient
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/279245116601433cb6a5936270b50c78
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A case of HPV-53-related cervical cancer in an elderly patient

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