Antibody-secreting cell destiny emerges during the initial stages of B-cell activation

The development of activated B cells into antibody-secreting cells (ASC) is a critical step for humoral immunity. Here the authors show, using adoptive transfers and single cell RNA sequencing, that commitment to ASC occurs soon following B cell activation, and is coordinated by specific transcripto...

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Autores principales:	Christopher D. Scharer, Dillon G. Patterson, Tian Mi, Madeline J. Price, Sakeenah L. Hicks, Jeremy M. Boss
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/279286b32b4a46bfa72d332ce28e2321
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spelling	oai:doaj.org-article:279286b32b4a46bfa72d332ce28e23212021-12-02T19:06:29ZAntibody-secreting cell destiny emerges during the initial stages of B-cell activation10.1038/s41467-020-17798-x2041-1723https://doaj.org/article/279286b32b4a46bfa72d332ce28e23212020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17798-xhttps://doaj.org/toc/2041-1723The development of activated B cells into antibody-secreting cells (ASC) is a critical step for humoral immunity. Here the authors show, using adoptive transfers and single cell RNA sequencing, that commitment to ASC occurs soon following B cell activation, and is coordinated by specific transcriptome programs and proliferation kinetics.Christopher D. ScharerDillon G. PattersonTian MiMadeline J. PriceSakeenah L. HicksJeremy M. BossNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Christopher D. Scharer Dillon G. Patterson Tian Mi Madeline J. Price Sakeenah L. Hicks Jeremy M. Boss Antibody-secreting cell destiny emerges during the initial stages of B-cell activation
description	The development of activated B cells into antibody-secreting cells (ASC) is a critical step for humoral immunity. Here the authors show, using adoptive transfers and single cell RNA sequencing, that commitment to ASC occurs soon following B cell activation, and is coordinated by specific transcriptome programs and proliferation kinetics.
format	article
author	Christopher D. Scharer Dillon G. Patterson Tian Mi Madeline J. Price Sakeenah L. Hicks Jeremy M. Boss
author_facet	Christopher D. Scharer Dillon G. Patterson Tian Mi Madeline J. Price Sakeenah L. Hicks Jeremy M. Boss
author_sort	Christopher D. Scharer
title	Antibody-secreting cell destiny emerges during the initial stages of B-cell activation
title_short	Antibody-secreting cell destiny emerges during the initial stages of B-cell activation
title_full	Antibody-secreting cell destiny emerges during the initial stages of B-cell activation
title_fullStr	Antibody-secreting cell destiny emerges during the initial stages of B-cell activation
title_full_unstemmed	Antibody-secreting cell destiny emerges during the initial stages of B-cell activation
title_sort	antibody-secreting cell destiny emerges during the initial stages of b-cell activation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/279286b32b4a46bfa72d332ce28e2321
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Antibody-secreting cell destiny emerges during the initial stages of B-cell activation

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