High-efficiency RNA-based reprogramming of human primary fibroblasts

Induced pluripotent stem cells (iPSCs) have potential for regenerative medicine applications, but are generated with very low efficiency. Here, the authors show highly efficient reprogramming of human primary fibroblasts to iPSCs via the synergistic activity of synthetic modified mRNAs, mature miRNA...

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Autores principales:	Igor Kogut, Sandra M. McCarthy, Maryna Pavlova, David P. Astling, Xiaomi Chen, Ana Jakimenko, Kenneth L. Jones, Andrew Getahun, John C. Cambier, Anna M. G. Pasmooij, Marcel F. Jonkman, Dennis R. Roop, Ganna Bilousova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/279523f467794ff7bb0f3d426b9968a3
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spelling	oai:doaj.org-article:279523f467794ff7bb0f3d426b9968a32021-12-02T14:40:31ZHigh-efficiency RNA-based reprogramming of human primary fibroblasts10.1038/s41467-018-03190-32041-1723https://doaj.org/article/279523f467794ff7bb0f3d426b9968a32018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03190-3https://doaj.org/toc/2041-1723Induced pluripotent stem cells (iPSCs) have potential for regenerative medicine applications, but are generated with very low efficiency. Here, the authors show highly efficient reprogramming of human primary fibroblasts to iPSCs via the synergistic activity of synthetic modified mRNAs, mature miRNA mimics, and optimized culture methods.Igor KogutSandra M. McCarthyMaryna PavlovaDavid P. AstlingXiaomi ChenAna JakimenkoKenneth L. JonesAndrew GetahunJohn C. CambierAnna M. G. PasmooijMarcel F. JonkmanDennis R. RoopGanna BilousovaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Igor Kogut Sandra M. McCarthy Maryna Pavlova David P. Astling Xiaomi Chen Ana Jakimenko Kenneth L. Jones Andrew Getahun John C. Cambier Anna M. G. Pasmooij Marcel F. Jonkman Dennis R. Roop Ganna Bilousova High-efficiency RNA-based reprogramming of human primary fibroblasts
description	Induced pluripotent stem cells (iPSCs) have potential for regenerative medicine applications, but are generated with very low efficiency. Here, the authors show highly efficient reprogramming of human primary fibroblasts to iPSCs via the synergistic activity of synthetic modified mRNAs, mature miRNA mimics, and optimized culture methods.
format	article
author	Igor Kogut Sandra M. McCarthy Maryna Pavlova David P. Astling Xiaomi Chen Ana Jakimenko Kenneth L. Jones Andrew Getahun John C. Cambier Anna M. G. Pasmooij Marcel F. Jonkman Dennis R. Roop Ganna Bilousova
author_facet	Igor Kogut Sandra M. McCarthy Maryna Pavlova David P. Astling Xiaomi Chen Ana Jakimenko Kenneth L. Jones Andrew Getahun John C. Cambier Anna M. G. Pasmooij Marcel F. Jonkman Dennis R. Roop Ganna Bilousova
author_sort	Igor Kogut
title	High-efficiency RNA-based reprogramming of human primary fibroblasts
title_short	High-efficiency RNA-based reprogramming of human primary fibroblasts
title_full	High-efficiency RNA-based reprogramming of human primary fibroblasts
title_fullStr	High-efficiency RNA-based reprogramming of human primary fibroblasts
title_full_unstemmed	High-efficiency RNA-based reprogramming of human primary fibroblasts
title_sort	high-efficiency rna-based reprogramming of human primary fibroblasts
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/279523f467794ff7bb0f3d426b9968a3
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High-efficiency RNA-based reprogramming of human primary fibroblasts

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