Complement C3 mediates early hippocampal neurodegeneration and memory impairment in experimental multiple sclerosis

Complement C3 mediates early hippocampal neurodegeneration and memory impairment in experimental multiple sclerosis

Memory impairment is one of the disabling manifestations of multiple sclerosis (MS) possibly present from the early stages of the disease and for which there is no specific treatment. Hippocampal synaptic dysfunction and dendritic loss, associated with microglial activation, can underlie memory defi...

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Autores principales: Julien Bourel, Vincent Planche, Nadège Dubourdieu, Aymeric Oliveira, Alexandra Séré, Eva-Gunnel Ducourneau, Marion Tible, Marlène Maitre, Thierry Lesté-Lasserre, Agnes Nadjar, Aline Desmedt, Philippe Ciofi, Stéphane H. Oliet, Aude Panatier, Thomas Tourdias
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
Materias:
Multiple sclerosis
Memory deficit
hippocampus
Neurodegeneration
Complement
Microglia
Neurosciences. Biological psychiatry. Neuropsychiatry
RC321-571
Acceso en línea:https://doaj.org/article/2795f1f4556d468198d33235f37e06f4
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https://doaj.org/article/2795f1f4556d468198d33235f37e06f4

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