KCNQ channel openers reverse depressive symptoms via an active resilience mechanism

Potassium channels in the ventral tegmental area are known to regulate resilience against stress-induced depression. Here, the authors show over expression of KCNQ3 channels in VTA dopaminergic neurons or treatment with KCNQ channel openers normalizes depressive behaviours in mouse models.

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Autores principales:	Allyson K. Friedman, Barbara Juarez, Stacy M. Ku, Hongxing Zhang, Rhodora C. Calizo, Jessica J. Walsh, Dipesh Chaudhury, Song Zhang, Angel Hawkins, David M. Dietz, James W. Murrough, Maria Ribadeneira, Erik H. Wong, Rachael L. Neve, Ming-Hu Han
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/27a25b5d540741f383c902474985df50
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spelling	oai:doaj.org-article:27a25b5d540741f383c902474985df502021-12-02T16:49:43ZKCNQ channel openers reverse depressive symptoms via an active resilience mechanism10.1038/ncomms116712041-1723https://doaj.org/article/27a25b5d540741f383c902474985df502016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11671https://doaj.org/toc/2041-1723Potassium channels in the ventral tegmental area are known to regulate resilience against stress-induced depression. Here, the authors show over expression of KCNQ3 channels in VTA dopaminergic neurons or treatment with KCNQ channel openers normalizes depressive behaviours in mouse models.Allyson K. FriedmanBarbara JuarezStacy M. KuHongxing ZhangRhodora C. CalizoJessica J. WalshDipesh ChaudhurySong ZhangAngel HawkinsDavid M. DietzJames W. MurroughMaria RibadeneiraErik H. WongRachael L. NeveMing-Hu HanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Allyson K. Friedman Barbara Juarez Stacy M. Ku Hongxing Zhang Rhodora C. Calizo Jessica J. Walsh Dipesh Chaudhury Song Zhang Angel Hawkins David M. Dietz James W. Murrough Maria Ribadeneira Erik H. Wong Rachael L. Neve Ming-Hu Han KCNQ channel openers reverse depressive symptoms via an active resilience mechanism
description	Potassium channels in the ventral tegmental area are known to regulate resilience against stress-induced depression. Here, the authors show over expression of KCNQ3 channels in VTA dopaminergic neurons or treatment with KCNQ channel openers normalizes depressive behaviours in mouse models.
format	article
author	Allyson K. Friedman Barbara Juarez Stacy M. Ku Hongxing Zhang Rhodora C. Calizo Jessica J. Walsh Dipesh Chaudhury Song Zhang Angel Hawkins David M. Dietz James W. Murrough Maria Ribadeneira Erik H. Wong Rachael L. Neve Ming-Hu Han
author_facet	Allyson K. Friedman Barbara Juarez Stacy M. Ku Hongxing Zhang Rhodora C. Calizo Jessica J. Walsh Dipesh Chaudhury Song Zhang Angel Hawkins David M. Dietz James W. Murrough Maria Ribadeneira Erik H. Wong Rachael L. Neve Ming-Hu Han
author_sort	Allyson K. Friedman
title	KCNQ channel openers reverse depressive symptoms via an active resilience mechanism
title_short	KCNQ channel openers reverse depressive symptoms via an active resilience mechanism
title_full	KCNQ channel openers reverse depressive symptoms via an active resilience mechanism
title_fullStr	KCNQ channel openers reverse depressive symptoms via an active resilience mechanism
title_full_unstemmed	KCNQ channel openers reverse depressive symptoms via an active resilience mechanism
title_sort	kcnq channel openers reverse depressive symptoms via an active resilience mechanism
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/27a25b5d540741f383c902474985df50
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KCNQ channel openers reverse depressive symptoms via an active resilience mechanism

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