Frequencies of MNS Blood Group Antigens and Phenotypes in Southwestern Saudi Arabia

Amr J Halawani,1 Mahmoud M Habibullah,2,3 Gasim Dobie,2 Alaa Alhazmi,2,3 Farkad Bantun,4 Mohammed H Nahari,5 Ibrahim Dawmary,6 Hisham I Abu-Tawil6,7 1Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia; 2Department of Medical Laborator...

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Autores principales:	Halawani AJ, Habibullah MM, Dobie G, Alhazmi A, Bantun F, Nahari MH, Dawmary I, Abu-Tawil HI
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	mns blood group blood donors transfusion saudi arabia Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/27a85f44f2e64a26a1e6c317b7b18507
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spelling	oai:doaj.org-article:27a85f44f2e64a26a1e6c317b7b185072021-12-05T18:27:45ZFrequencies of MNS Blood Group Antigens and Phenotypes in Southwestern Saudi Arabia1178-7074https://doaj.org/article/27a85f44f2e64a26a1e6c317b7b185072021-12-01T00:00:00Zhttps://www.dovepress.com/frequencies-of-mns-blood-group-antigens-and-phenotypes-in-southwestern-peer-reviewed-fulltext-article-IJGMhttps://doaj.org/toc/1178-7074Amr J Halawani,1 Mahmoud M Habibullah,2,3 Gasim Dobie,2 Alaa Alhazmi,2,3 Farkad Bantun,4 Mohammed H Nahari,5 Ibrahim Dawmary,6 Hisham I Abu-Tawil6,7 1Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia; 2Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia; 3SMIRES for Consultation in Specialized Medical Laboratories, Jazan University, Jazan, Saudi Arabia; 4Department of Microbiology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia; 5Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Najran University, Najran, Saudi Arabia; 6Department of Laboratory and Blood Bank, Prince Mohammed bin Nasser Hospital, Ministry of Health, Jazan, Saudi Arabia; 7Department of Laboratory and Blood Bank, King Faisal Medical City for Southern Regions, Ministry of Health, Abha, Saudi ArabiaCorrespondence: Amr J Halawani Makkah, 24381 8156, Saudi ArabiaEmail ajjhalawani@uqu.edu.saPurpose: Knowledge of the prevalence of blood group antigens in a given population is important for the prevention of hemolytic reactions. The MNS blood group system (002) has four polymorphic antigens—M, N, S, and s. Anti-S and anti-s antibodies may result in immediate and delayed hemolytic transfusion reactions, and hemolytic disease of the fetus and newborn may occur. The present study investigated the frequencies of the main antigens and phenotypes of the MNS blood group system.Subjects and Methods: We randomly obtained 149 samples from anonymous Saudi blood donors living in Jazan Province. Serotyping was conducted using a gel card to investigate (M, N, S, and s) antigens and phenotypes.Results: The frequencies of MNS antigens were as follows: M = 89.26%, N = 51.67%, S = 61.07%, and s = 82.55%. Regarding the MNS phenotypes, nine phenotypes were observed in the study population. The most common phenotype was M+N–S+s+ (n = 36, 24.16%), in contrast to the least common phenotype M+N–S–s– (n = 1, 0.67%). The prevalence of the MNS phenotypes in the current study population was highly and significantly different from that in Europeans (P = 0.044) and African Americans (P = 0.000).Conclusion: In summary, this study reports the frequencies of the MNS antigens and phenotypes in Jazan Province, Saudi Arabia. The most common phenotype was M+N–S+s+, whereas the least observed phenotype was M+N–S–s–. The outcomes of this study may assist the blood banks in Jazan Province to establish an extended phenotyping protocol including the MNS antigens, in particular S and s antigens, to preclude any alloimmunization events.Keywords: MNS blood group, blood donors, transfusion, Saudi ArabiaHalawani AJHabibullah MMDobie GAlhazmi ABantun FNahari MHDawmary IAbu-Tawil HIDove Medical Pressarticlemns blood groupblood donorstransfusionsaudi arabiaMedicine (General)R5-920ENInternational Journal of General Medicine, Vol Volume 14, Pp 9315-9319 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mns blood group blood donors transfusion saudi arabia Medicine (General) R5-920
spellingShingle	mns blood group blood donors transfusion saudi arabia Medicine (General) R5-920 Halawani AJ Habibullah MM Dobie G Alhazmi A Bantun F Nahari MH Dawmary I Abu-Tawil HI Frequencies of MNS Blood Group Antigens and Phenotypes in Southwestern Saudi Arabia
description	Amr J Halawani,1 Mahmoud M Habibullah,2,3 Gasim Dobie,2 Alaa Alhazmi,2,3 Farkad Bantun,4 Mohammed H Nahari,5 Ibrahim Dawmary,6 Hisham I Abu-Tawil6,7 1Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia; 2Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia; 3SMIRES for Consultation in Specialized Medical Laboratories, Jazan University, Jazan, Saudi Arabia; 4Department of Microbiology, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia; 5Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Najran University, Najran, Saudi Arabia; 6Department of Laboratory and Blood Bank, Prince Mohammed bin Nasser Hospital, Ministry of Health, Jazan, Saudi Arabia; 7Department of Laboratory and Blood Bank, King Faisal Medical City for Southern Regions, Ministry of Health, Abha, Saudi ArabiaCorrespondence: Amr J Halawani Makkah, 24381 8156, Saudi ArabiaEmail ajjhalawani@uqu.edu.saPurpose: Knowledge of the prevalence of blood group antigens in a given population is important for the prevention of hemolytic reactions. The MNS blood group system (002) has four polymorphic antigens—M, N, S, and s. Anti-S and anti-s antibodies may result in immediate and delayed hemolytic transfusion reactions, and hemolytic disease of the fetus and newborn may occur. The present study investigated the frequencies of the main antigens and phenotypes of the MNS blood group system.Subjects and Methods: We randomly obtained 149 samples from anonymous Saudi blood donors living in Jazan Province. Serotyping was conducted using a gel card to investigate (M, N, S, and s) antigens and phenotypes.Results: The frequencies of MNS antigens were as follows: M = 89.26%, N = 51.67%, S = 61.07%, and s = 82.55%. Regarding the MNS phenotypes, nine phenotypes were observed in the study population. The most common phenotype was M+N–S+s+ (n = 36, 24.16%), in contrast to the least common phenotype M+N–S–s– (n = 1, 0.67%). The prevalence of the MNS phenotypes in the current study population was highly and significantly different from that in Europeans (P = 0.044) and African Americans (P = 0.000).Conclusion: In summary, this study reports the frequencies of the MNS antigens and phenotypes in Jazan Province, Saudi Arabia. The most common phenotype was M+N–S+s+, whereas the least observed phenotype was M+N–S–s–. The outcomes of this study may assist the blood banks in Jazan Province to establish an extended phenotyping protocol including the MNS antigens, in particular S and s antigens, to preclude any alloimmunization events.Keywords: MNS blood group, blood donors, transfusion, Saudi Arabia
format	article
author	Halawani AJ Habibullah MM Dobie G Alhazmi A Bantun F Nahari MH Dawmary I Abu-Tawil HI
author_facet	Halawani AJ Habibullah MM Dobie G Alhazmi A Bantun F Nahari MH Dawmary I Abu-Tawil HI
author_sort	Halawani AJ
title	Frequencies of MNS Blood Group Antigens and Phenotypes in Southwestern Saudi Arabia
title_short	Frequencies of MNS Blood Group Antigens and Phenotypes in Southwestern Saudi Arabia
title_full	Frequencies of MNS Blood Group Antigens and Phenotypes in Southwestern Saudi Arabia
title_fullStr	Frequencies of MNS Blood Group Antigens and Phenotypes in Southwestern Saudi Arabia
title_full_unstemmed	Frequencies of MNS Blood Group Antigens and Phenotypes in Southwestern Saudi Arabia
title_sort	frequencies of mns blood group antigens and phenotypes in southwestern saudi arabia
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/27a85f44f2e64a26a1e6c317b7b18507
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Frequencies of MNS Blood Group Antigens and Phenotypes in Southwestern Saudi Arabia

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