Incidence and management patterns of alcohol-related liver disease in Korea: a nationwide standard cohort study

Abstract The recent incidence and management patterns of alcohol-related liver disease (ARLD) are not well defined in Korea. We sought to evaluate the epidemiology of ARLD with regard to disease severity and alcohol cessation management after diagnosis. We performed an observational cohort study of...

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Autores principales:	Ha Il Kim, Seo Young Park, Hyun Phil Shin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/27ad70ac9e404352a3936ec877c918c9
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spelling	oai:doaj.org-article:27ad70ac9e404352a3936ec877c918c92021-12-02T16:36:04ZIncidence and management patterns of alcohol-related liver disease in Korea: a nationwide standard cohort study10.1038/s41598-021-86197-z2045-2322https://doaj.org/article/27ad70ac9e404352a3936ec877c918c92021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86197-zhttps://doaj.org/toc/2045-2322Abstract The recent incidence and management patterns of alcohol-related liver disease (ARLD) are not well defined in Korea. We sought to evaluate the epidemiology of ARLD with regard to disease severity and alcohol cessation management after diagnosis. We performed an observational cohort study of standardized Common Data Model data from the Health Insurance Review and Assessment-National Patient Samples database between 2012 and 2016. The incidence and demographic properties of ARLD were extracted and divided into non-cirrhotic alcoholic liver disease (ALD) and alcoholic liver cirrhosis (ALC). ALC was compared with non-alcoholic cirrhosis by severity at diagnosis. The management patterns were captured by the initiation of pharmaco- and behavioral therapy for alcohol cessation. We analyzed data from 72,556 ALD to 7295 ALC patients. The ALD incidence was stable from 990 to 1025 per 100,000 people. In ALD, the proportion of patients who were ≥ 65 years old, the proportion of female patients, and the comorbidity index increased significantly during the study period (all P values < 0.001). ALC accounted for > 20% of all cirrhosis, with decompensation occurring twice as often as in non-alcoholic cirrhosis. The initiation of alcoholism management was stationary in ARLD, remaining at < 10% for both pharmacotherapy and behavioral therapy, regardless of severity or the site of diagnosis. The incidence of ARLD did not decrease during the study period. Moreover, an increasing trend in the proportion of people vulnerable to drinking was observed. Unfortunately, management for the cessation of alcohol use remains very low. The best way to manage ARLD should be evaluated in further study.Ha Il KimSeo Young ParkHyun Phil ShinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ha Il Kim Seo Young Park Hyun Phil Shin Incidence and management patterns of alcohol-related liver disease in Korea: a nationwide standard cohort study
description	Abstract The recent incidence and management patterns of alcohol-related liver disease (ARLD) are not well defined in Korea. We sought to evaluate the epidemiology of ARLD with regard to disease severity and alcohol cessation management after diagnosis. We performed an observational cohort study of standardized Common Data Model data from the Health Insurance Review and Assessment-National Patient Samples database between 2012 and 2016. The incidence and demographic properties of ARLD were extracted and divided into non-cirrhotic alcoholic liver disease (ALD) and alcoholic liver cirrhosis (ALC). ALC was compared with non-alcoholic cirrhosis by severity at diagnosis. The management patterns were captured by the initiation of pharmaco- and behavioral therapy for alcohol cessation. We analyzed data from 72,556 ALD to 7295 ALC patients. The ALD incidence was stable from 990 to 1025 per 100,000 people. In ALD, the proportion of patients who were ≥ 65 years old, the proportion of female patients, and the comorbidity index increased significantly during the study period (all P values < 0.001). ALC accounted for > 20% of all cirrhosis, with decompensation occurring twice as often as in non-alcoholic cirrhosis. The initiation of alcoholism management was stationary in ARLD, remaining at < 10% for both pharmacotherapy and behavioral therapy, regardless of severity or the site of diagnosis. The incidence of ARLD did not decrease during the study period. Moreover, an increasing trend in the proportion of people vulnerable to drinking was observed. Unfortunately, management for the cessation of alcohol use remains very low. The best way to manage ARLD should be evaluated in further study.
format	article
author	Ha Il Kim Seo Young Park Hyun Phil Shin
author_facet	Ha Il Kim Seo Young Park Hyun Phil Shin
author_sort	Ha Il Kim
title	Incidence and management patterns of alcohol-related liver disease in Korea: a nationwide standard cohort study
title_short	Incidence and management patterns of alcohol-related liver disease in Korea: a nationwide standard cohort study
title_full	Incidence and management patterns of alcohol-related liver disease in Korea: a nationwide standard cohort study
title_fullStr	Incidence and management patterns of alcohol-related liver disease in Korea: a nationwide standard cohort study
title_full_unstemmed	Incidence and management patterns of alcohol-related liver disease in Korea: a nationwide standard cohort study
title_sort	incidence and management patterns of alcohol-related liver disease in korea: a nationwide standard cohort study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/27ad70ac9e404352a3936ec877c918c9
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Incidence and management patterns of alcohol-related liver disease in Korea: a nationwide standard cohort study

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