A double-blind, placebo-controlled study on the effects of lutein and zeaxanthin on neural processing speed and efficiency.

Lutein and zeaxanthin are major carotenoids in the eye but are also found in post-receptoral visual pathways. It has been hypothesized that these pigments influence the processing of visual signals within and post-retina, and that increasing lutein and zeaxanthin levels within the visual system will...

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Autores principales:	Emily R Bovier, Lisa M Renzi, Billy R Hammond
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/27ad8e51a8904d3886cd493f1a598abc
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spelling	oai:doaj.org-article:27ad8e51a8904d3886cd493f1a598abc2021-11-25T05:59:28ZA double-blind, placebo-controlled study on the effects of lutein and zeaxanthin on neural processing speed and efficiency.1932-620310.1371/journal.pone.0108178https://doaj.org/article/27ad8e51a8904d3886cd493f1a598abc2014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0108178https://doaj.org/toc/1932-6203Lutein and zeaxanthin are major carotenoids in the eye but are also found in post-receptoral visual pathways. It has been hypothesized that these pigments influence the processing of visual signals within and post-retina, and that increasing lutein and zeaxanthin levels within the visual system will lead to increased visual processing speeds. To test this, we measured macular pigment density (as a biomarker of lutein and zeaxanthin levels in brain), critical flicker fusion (CFF) thresholds, and visual motor reaction time in young healthy subjects (n = 92). Changes in these outcome variables were also assessed after four months of supplementation with either placebo (n = 10), zeaxanthin only (20 mg/day; n = 29) or a mixed formulation containing 26 mg/day zeaxanthin, 8 mg/day lutein, and 190 mg/day mixed omega-3 fatty acids (n = 25). Significant correlations were found between retinal lutein and zeaxanthin (macular pigment) and CFF thresholds (p<0.01) and visual motor performance (overall p<0.01). Supplementation with zeaxanthin and the mixed formulation (considered together) produced significant (p<0.01) increases in CFF thresholds (∼12%) and visual motor reaction time (∼10%) compared to placebo. In general, increasing macular pigment density through supplementation (average increase of about 0.09 log units) resulted in significant improvements in visual processing speed, even when testing young, healthy individuals who tend to be at peak efficiency.Emily R BovierLisa M RenziBilly R HammondPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 9, p e108178 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Emily R Bovier Lisa M Renzi Billy R Hammond A double-blind, placebo-controlled study on the effects of lutein and zeaxanthin on neural processing speed and efficiency.
description	Lutein and zeaxanthin are major carotenoids in the eye but are also found in post-receptoral visual pathways. It has been hypothesized that these pigments influence the processing of visual signals within and post-retina, and that increasing lutein and zeaxanthin levels within the visual system will lead to increased visual processing speeds. To test this, we measured macular pigment density (as a biomarker of lutein and zeaxanthin levels in brain), critical flicker fusion (CFF) thresholds, and visual motor reaction time in young healthy subjects (n = 92). Changes in these outcome variables were also assessed after four months of supplementation with either placebo (n = 10), zeaxanthin only (20 mg/day; n = 29) or a mixed formulation containing 26 mg/day zeaxanthin, 8 mg/day lutein, and 190 mg/day mixed omega-3 fatty acids (n = 25). Significant correlations were found between retinal lutein and zeaxanthin (macular pigment) and CFF thresholds (p<0.01) and visual motor performance (overall p<0.01). Supplementation with zeaxanthin and the mixed formulation (considered together) produced significant (p<0.01) increases in CFF thresholds (∼12%) and visual motor reaction time (∼10%) compared to placebo. In general, increasing macular pigment density through supplementation (average increase of about 0.09 log units) resulted in significant improvements in visual processing speed, even when testing young, healthy individuals who tend to be at peak efficiency.
format	article
author	Emily R Bovier Lisa M Renzi Billy R Hammond
author_facet	Emily R Bovier Lisa M Renzi Billy R Hammond
author_sort	Emily R Bovier
title	A double-blind, placebo-controlled study on the effects of lutein and zeaxanthin on neural processing speed and efficiency.
title_short	A double-blind, placebo-controlled study on the effects of lutein and zeaxanthin on neural processing speed and efficiency.
title_full	A double-blind, placebo-controlled study on the effects of lutein and zeaxanthin on neural processing speed and efficiency.
title_fullStr	A double-blind, placebo-controlled study on the effects of lutein and zeaxanthin on neural processing speed and efficiency.
title_full_unstemmed	A double-blind, placebo-controlled study on the effects of lutein and zeaxanthin on neural processing speed and efficiency.
title_sort	double-blind, placebo-controlled study on the effects of lutein and zeaxanthin on neural processing speed and efficiency.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/27ad8e51a8904d3886cd493f1a598abc
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A double-blind, placebo-controlled study on the effects of lutein and zeaxanthin on neural processing speed and efficiency.

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