A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition

A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition

Cancer cells are metabolically adaptable and the identification of specific vulnerabilities is challenging. Here the authors identify a subset of neuroendocrine cell lines exquisitely sensitive to inhibition of SQLE, an enzyme in the cholesterol biosynthetic pathway, due to the toxic accumulation of...

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Autores principales: Christopher E. Mahoney, David Pirman, Victor Chubukov, Taryn Sleger, Sebastian Hayes, Zi Peng Fan, Eric L. Allen, Ying Chen, Lingling Huang, Meina Liu, Yingjia Zhang, Gabrielle McDonald, Rohini Narayanaswamy, Sung Choe, Yue Chen, Stefan Gross, Giovanni Cianchetta, Anil K. Padyana, Stuart Murray, Wei Liu, Kevin M. Marks, Joshua Murtie, Marion Dorsch, Shengfang Jin, Nelamangala Nagaraja, Scott A. Biller, Thomas Roddy, Janeta Popovici-Muller, Gromoslaw A. Smolen
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/27aeab8f4bce40e788924435c21f0b77
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spelling oai:doaj.org-article:27aeab8f4bce40e788924435c21f0b772021-12-02T14:38:38ZA chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition10.1038/s41467-018-07959-42041-1723https://doaj.org/article/27aeab8f4bce40e788924435c21f0b772019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07959-4https://doaj.org/toc/2041-1723Cancer cells are metabolically adaptable and the identification of specific vulnerabilities is challenging. Here the authors identify a subset of neuroendocrine cell lines exquisitely sensitive to inhibition of SQLE, an enzyme in the cholesterol biosynthetic pathway, due to the toxic accumulation of pathway intermediate squalene.Christopher E. MahoneyDavid PirmanVictor ChubukovTaryn SlegerSebastian HayesZi Peng FanEric L. AllenYing ChenLingling HuangMeina LiuYingjia ZhangGabrielle McDonaldRohini NarayanaswamySung ChoeYue ChenStefan GrossGiovanni CianchettaAnil K. PadyanaStuart MurrayWei LiuKevin M. MarksJoshua MurtieMarion DorschShengfang JinNelamangala NagarajaScott A. BillerThomas RoddyJaneta Popovici-MullerGromoslaw A. SmolenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Christopher E. Mahoney
David Pirman
Victor Chubukov
Taryn Sleger
Sebastian Hayes
Zi Peng Fan
Eric L. Allen
Ying Chen
Lingling Huang
Meina Liu
Yingjia Zhang
Gabrielle McDonald
Rohini Narayanaswamy
Sung Choe
Yue Chen
Stefan Gross
Giovanni Cianchetta
Anil K. Padyana
Stuart Murray
Wei Liu
Kevin M. Marks
Joshua Murtie
Marion Dorsch
Shengfang Jin
Nelamangala Nagaraja
Scott A. Biller
Thomas Roddy
Janeta Popovici-Muller
Gromoslaw A. Smolen
A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition
description Cancer cells are metabolically adaptable and the identification of specific vulnerabilities is challenging. Here the authors identify a subset of neuroendocrine cell lines exquisitely sensitive to inhibition of SQLE, an enzyme in the cholesterol biosynthetic pathway, due to the toxic accumulation of pathway intermediate squalene.
format article
author Christopher E. Mahoney
David Pirman
Victor Chubukov
Taryn Sleger
Sebastian Hayes
Zi Peng Fan
Eric L. Allen
Ying Chen
Lingling Huang
Meina Liu
Yingjia Zhang
Gabrielle McDonald
Rohini Narayanaswamy
Sung Choe
Yue Chen
Stefan Gross
Giovanni Cianchetta
Anil K. Padyana
Stuart Murray
Wei Liu
Kevin M. Marks
Joshua Murtie
Marion Dorsch
Shengfang Jin
Nelamangala Nagaraja
Scott A. Biller
Thomas Roddy
Janeta Popovici-Muller
Gromoslaw A. Smolen
author_facet Christopher E. Mahoney
David Pirman
Victor Chubukov
Taryn Sleger
Sebastian Hayes
Zi Peng Fan
Eric L. Allen
Ying Chen
Lingling Huang
Meina Liu
Yingjia Zhang
Gabrielle McDonald
Rohini Narayanaswamy
Sung Choe
Yue Chen
Stefan Gross
Giovanni Cianchetta
Anil K. Padyana
Stuart Murray
Wei Liu
Kevin M. Marks
Joshua Murtie
Marion Dorsch
Shengfang Jin
Nelamangala Nagaraja
Scott A. Biller
Thomas Roddy
Janeta Popovici-Muller
Gromoslaw A. Smolen
author_sort Christopher E. Mahoney
title A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition
title_short A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition
title_full A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition
title_fullStr A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition
title_full_unstemmed A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition
title_sort chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to sqle inhibition
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/27aeab8f4bce40e788924435c21f0b77
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