Polyphenols from Blumea laciniata Extended the Lifespan and Enhanced Resistance to Stress in Caenorhabditis elegans via the Insulin Signaling Pathway

Blumea laciniata is widely used as a folk medicine in Asia, but relevant literature on it is rarely reported. We confirmed that polyphenol extract (containing chlorogenic acid, rutin, and luteolin-4-O-glucoside) from B. laciniata (EBL) showed strong antioxidant...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Tao Chen, Siyuan Luo, Xiaoju Wang, Yiling Zhou, Yali Dai, Lijun Zhou, Shiling Feng, Ming Yuan, Chunbang Ding
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Blumea laciniata</i> antioxidant ability anti-ageing effect <i>Caenorhabditis elegans</i> Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/27af7d1c2ba54cfea4af2dc8036bf263
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:27af7d1c2ba54cfea4af2dc8036bf263
record_format	dspace
spelling	oai:doaj.org-article:27af7d1c2ba54cfea4af2dc8036bf2632021-11-25T16:27:40ZPolyphenols from <i>Blumea laciniata</i> Extended the Lifespan and Enhanced Resistance to Stress in <i>Caenorhabditis elegans</i> via the Insulin Signaling Pathway10.3390/antiox101117442076-3921https://doaj.org/article/27af7d1c2ba54cfea4af2dc8036bf2632021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1744https://doaj.org/toc/2076-3921<i>Blumea laciniata</i> is widely used as a folk medicine in Asia, but relevant literature on it is rarely reported. We confirmed that polyphenol extract (containing chlorogenic acid, rutin, and luteolin-4-O-glucoside) from <i>B. laciniata</i> (EBL) showed strong antioxidant ability in vitro. Hence, in this work, we applied <i>Caenorhabditis elegans</i> to further investigate the antioxidant and anti-ageing abilities of EBL in vivo. The results showed that EBL enhanced the survival of <i>C. elegans</i> under thermal stress by 12.62% and sharply reduced the reactive oxygen species level as well as the content of malonaldehyde. Moreover, EBL increased the activities of antioxidant enzymes such as catalase and superoxide dismutase. Additionally, EBL promoted DAF-16, a transcription factor, into the nucleus. Besides, EBL extended the lifespan of <i>C. elegans</i> by 17.39%, showing an anti-ageing effect. Different mutants indicated that the insulin/IGF-1 signaling pathway participated in the antioxidant and anti-ageing effect of EBL on <i>C. elegans</i>.Tao ChenSiyuan LuoXiaoju WangYiling ZhouYali DaiLijun ZhouShiling FengMing YuanChunbang DingMDPI AGarticle<i>Blumea laciniata</i>antioxidant abilityanti-ageing effect<i>Caenorhabditis elegans</i>Therapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1744, p 1744 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Blumea laciniata</i> antioxidant ability anti-ageing effect <i>Caenorhabditis elegans</i> Therapeutics. Pharmacology RM1-950
spellingShingle	<i>Blumea laciniata</i> antioxidant ability anti-ageing effect <i>Caenorhabditis elegans</i> Therapeutics. Pharmacology RM1-950 Tao Chen Siyuan Luo Xiaoju Wang Yiling Zhou Yali Dai Lijun Zhou Shiling Feng Ming Yuan Chunbang Ding Polyphenols from <i>Blumea laciniata</i> Extended the Lifespan and Enhanced Resistance to Stress in <i>Caenorhabditis elegans</i> via the Insulin Signaling Pathway
description	<i>Blumea laciniata</i> is widely used as a folk medicine in Asia, but relevant literature on it is rarely reported. We confirmed that polyphenol extract (containing chlorogenic acid, rutin, and luteolin-4-O-glucoside) from <i>B. laciniata</i> (EBL) showed strong antioxidant ability in vitro. Hence, in this work, we applied <i>Caenorhabditis elegans</i> to further investigate the antioxidant and anti-ageing abilities of EBL in vivo. The results showed that EBL enhanced the survival of <i>C. elegans</i> under thermal stress by 12.62% and sharply reduced the reactive oxygen species level as well as the content of malonaldehyde. Moreover, EBL increased the activities of antioxidant enzymes such as catalase and superoxide dismutase. Additionally, EBL promoted DAF-16, a transcription factor, into the nucleus. Besides, EBL extended the lifespan of <i>C. elegans</i> by 17.39%, showing an anti-ageing effect. Different mutants indicated that the insulin/IGF-1 signaling pathway participated in the antioxidant and anti-ageing effect of EBL on <i>C. elegans</i>.
format	article
author	Tao Chen Siyuan Luo Xiaoju Wang Yiling Zhou Yali Dai Lijun Zhou Shiling Feng Ming Yuan Chunbang Ding
author_facet	Tao Chen Siyuan Luo Xiaoju Wang Yiling Zhou Yali Dai Lijun Zhou Shiling Feng Ming Yuan Chunbang Ding
author_sort	Tao Chen
title	Polyphenols from <i>Blumea laciniata</i> Extended the Lifespan and Enhanced Resistance to Stress in <i>Caenorhabditis elegans</i> via the Insulin Signaling Pathway
title_short	Polyphenols from <i>Blumea laciniata</i> Extended the Lifespan and Enhanced Resistance to Stress in <i>Caenorhabditis elegans</i> via the Insulin Signaling Pathway
title_full	Polyphenols from <i>Blumea laciniata</i> Extended the Lifespan and Enhanced Resistance to Stress in <i>Caenorhabditis elegans</i> via the Insulin Signaling Pathway
title_fullStr	Polyphenols from <i>Blumea laciniata</i> Extended the Lifespan and Enhanced Resistance to Stress in <i>Caenorhabditis elegans</i> via the Insulin Signaling Pathway
title_full_unstemmed	Polyphenols from <i>Blumea laciniata</i> Extended the Lifespan and Enhanced Resistance to Stress in <i>Caenorhabditis elegans</i> via the Insulin Signaling Pathway
title_sort	polyphenols from <i>blumea laciniata</i> extended the lifespan and enhanced resistance to stress in <i>caenorhabditis elegans</i> via the insulin signaling pathway
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/27af7d1c2ba54cfea4af2dc8036bf263
work_keys_str_mv	AT taochen polyphenolsfromiblumealaciniataiextendedthelifespanandenhancedresistancetostressinicaenorhabditiselegansiviatheinsulinsignalingpathway AT siyuanluo polyphenolsfromiblumealaciniataiextendedthelifespanandenhancedresistancetostressinicaenorhabditiselegansiviatheinsulinsignalingpathway AT xiaojuwang polyphenolsfromiblumealaciniataiextendedthelifespanandenhancedresistancetostressinicaenorhabditiselegansiviatheinsulinsignalingpathway AT yilingzhou polyphenolsfromiblumealaciniataiextendedthelifespanandenhancedresistancetostressinicaenorhabditiselegansiviatheinsulinsignalingpathway AT yalidai polyphenolsfromiblumealaciniataiextendedthelifespanandenhancedresistancetostressinicaenorhabditiselegansiviatheinsulinsignalingpathway AT lijunzhou polyphenolsfromiblumealaciniataiextendedthelifespanandenhancedresistancetostressinicaenorhabditiselegansiviatheinsulinsignalingpathway AT shilingfeng polyphenolsfromiblumealaciniataiextendedthelifespanandenhancedresistancetostressinicaenorhabditiselegansiviatheinsulinsignalingpathway AT mingyuan polyphenolsfromiblumealaciniataiextendedthelifespanandenhancedresistancetostressinicaenorhabditiselegansiviatheinsulinsignalingpathway AT chunbangding polyphenolsfromiblumealaciniataiextendedthelifespanandenhancedresistancetostressinicaenorhabditiselegansiviatheinsulinsignalingpathway
_version_	1718413124781998080

Polyphenols from <i>Blumea laciniata</i> Extended the Lifespan and Enhanced Resistance to Stress in <i>Caenorhabditis elegans</i> via the Insulin Signaling Pathway

Ejemplares similares