Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos
In the mouse embryo, anterior-posterior polarity is established by distal visceral endoderm (DVE) at embryonic day 5.5 but how this arises is unclear. Here, the authors show that expression of Lefty1 earlier can define DVE, and that future DVE cells are selected by Nodal signalling and stochasticity...
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| Autores principales: | , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2017
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/27afd91f581c4169ace787ed238630bd |
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| Sumario: | In the mouse embryo, anterior-posterior polarity is established by distal visceral endoderm (DVE) at embryonic day 5.5 but how this arises is unclear. Here, the authors show that expression of Lefty1 earlier can define DVE, and that future DVE cells are selected by Nodal signalling and stochasticity. |
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