Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos
In the mouse embryo, anterior-posterior polarity is established by distal visceral endoderm (DVE) at embryonic day 5.5 but how this arises is unclear. Here, the authors show that expression of Lefty1 earlier can define DVE, and that future DVE cells are selected by Nodal signalling and stochasticity...
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Nature Portfolio
2017
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oai:doaj.org-article:27afd91f581c4169ace787ed238630bd2021-12-02T14:40:45ZBoth Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos10.1038/s41467-017-01625-x2041-1723https://doaj.org/article/27afd91f581c4169ace787ed238630bd2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01625-xhttps://doaj.org/toc/2041-1723In the mouse embryo, anterior-posterior polarity is established by distal visceral endoderm (DVE) at embryonic day 5.5 but how this arises is unclear. Here, the authors show that expression of Lefty1 earlier can define DVE, and that future DVE cells are selected by Nodal signalling and stochasticity.Katsuyoshi TakaokaHiromi NishimuraHiroshi HamadaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017) |
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Science Q Katsuyoshi Takaoka Hiromi Nishimura Hiroshi Hamada Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos |
description |
In the mouse embryo, anterior-posterior polarity is established by distal visceral endoderm (DVE) at embryonic day 5.5 but how this arises is unclear. Here, the authors show that expression of Lefty1 earlier can define DVE, and that future DVE cells are selected by Nodal signalling and stochasticity. |
format |
article |
author |
Katsuyoshi Takaoka Hiromi Nishimura Hiroshi Hamada |
author_facet |
Katsuyoshi Takaoka Hiromi Nishimura Hiroshi Hamada |
author_sort |
Katsuyoshi Takaoka |
title |
Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos |
title_short |
Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos |
title_full |
Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos |
title_fullStr |
Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos |
title_full_unstemmed |
Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos |
title_sort |
both nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/27afd91f581c4169ace787ed238630bd |
work_keys_str_mv |
AT katsuyoshitakaoka bothnodalsignallingandstochasticityselectforprospectivedistalvisceralendoderminmouseembryos AT hirominishimura bothnodalsignallingandstochasticityselectforprospectivedistalvisceralendoderminmouseembryos AT hiroshihamada bothnodalsignallingandstochasticityselectforprospectivedistalvisceralendoderminmouseembryos |
_version_ |
1718390163336331264 |