Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos

In the mouse embryo, anterior-posterior polarity is established by distal visceral endoderm (DVE) at embryonic day 5.5 but how this arises is unclear. Here, the authors show that expression of Lefty1 earlier can define DVE, and that future DVE cells are selected by Nodal signalling and stochasticity...

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Auteurs principaux:	Katsuyoshi Takaoka, Hiromi Nishimura, Hiroshi Hamada
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/27afd91f581c4169ace787ed238630bd
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id	oai:doaj.org-article:27afd91f581c4169ace787ed238630bd
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spelling	oai:doaj.org-article:27afd91f581c4169ace787ed238630bd2021-12-02T14:40:45ZBoth Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos10.1038/s41467-017-01625-x2041-1723https://doaj.org/article/27afd91f581c4169ace787ed238630bd2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01625-xhttps://doaj.org/toc/2041-1723In the mouse embryo, anterior-posterior polarity is established by distal visceral endoderm (DVE) at embryonic day 5.5 but how this arises is unclear. Here, the authors show that expression of Lefty1 earlier can define DVE, and that future DVE cells are selected by Nodal signalling and stochasticity.Katsuyoshi TakaokaHiromi NishimuraHiroshi HamadaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Katsuyoshi Takaoka Hiromi Nishimura Hiroshi Hamada Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos
description	In the mouse embryo, anterior-posterior polarity is established by distal visceral endoderm (DVE) at embryonic day 5.5 but how this arises is unclear. Here, the authors show that expression of Lefty1 earlier can define DVE, and that future DVE cells are selected by Nodal signalling and stochasticity.
format	article
author	Katsuyoshi Takaoka Hiromi Nishimura Hiroshi Hamada
author_facet	Katsuyoshi Takaoka Hiromi Nishimura Hiroshi Hamada
author_sort	Katsuyoshi Takaoka
title	Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos
title_short	Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos
title_full	Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos
title_fullStr	Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos
title_full_unstemmed	Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos
title_sort	both nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/27afd91f581c4169ace787ed238630bd
work_keys_str_mv	AT katsuyoshitakaoka bothnodalsignallingandstochasticityselectforprospectivedistalvisceralendoderminmouseembryos AT hirominishimura bothnodalsignallingandstochasticityselectforprospectivedistalvisceralendoderminmouseembryos AT hiroshihamada bothnodalsignallingandstochasticityselectforprospectivedistalvisceralendoderminmouseembryos
_version_	1718390163336331264

Both Nodal signalling and stochasticity select for prospective distal visceral endoderm in mouse embryos

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