Impact of risk factors on different interval cancer subtypes in a population-based breast cancer screening programme.

<h4>Background</h4>Interval cancers are primary breast cancers diagnosed in women after a negative screening test and before the next screening invitation. Our aim was to evaluate risk factors for interval cancer and their subtypes and to compare the risk factors identified with those as...

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Autores principales:	Jordi Blanch, Maria Sala, Josefa Ibáñez, Laia Domingo, Belén Fernandez, Arantza Otegi, Teresa Barata, Raquel Zubizarreta, Joana Ferrer, Xavier Castells, Montserrat Rué, Dolores Salas, INCA Study Group
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/27b16eca5fad4e2386747d8678620049
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spelling	oai:doaj.org-article:27b16eca5fad4e2386747d86786200492021-11-25T05:55:42ZImpact of risk factors on different interval cancer subtypes in a population-based breast cancer screening programme.1932-620310.1371/journal.pone.0110207https://doaj.org/article/27b16eca5fad4e2386747d86786200492014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0110207https://doaj.org/toc/1932-6203<h4>Background</h4>Interval cancers are primary breast cancers diagnosed in women after a negative screening test and before the next screening invitation. Our aim was to evaluate risk factors for interval cancer and their subtypes and to compare the risk factors identified with those associated with incident screen-detected cancers.<h4>Methods</h4>We analyzed data from 645,764 women participating in the Spanish breast cancer screening program from 2000-2006 and followed-up until 2009. A total of 5,309 screen-detected and 1,653 interval cancers were diagnosed. Among the latter, 1,012 could be classified on the basis of findings in screening and diagnostic mammograms, consisting of 489 true interval cancers (48.2%), 235 false-negatives (23.2%), 172 minimal-signs (17.2%) and 114 occult tumors (11.3%). Information on the screening protocol and women's characteristics were obtained from the screening program registry. Cause-specific Cox regression models were used to estimate the hazard ratios (HR) of risks factors for interval cancer and incident screen-detected cancer. A multinomial regression model, using screen-detected tumors as a reference group, was used to assess the effect of breast density and other factors on the occurrence of interval cancer subtypes.<h4>Results</h4>A previous false-positive was the main risk factor for interval cancer (HR = 2.71, 95%CI: 2.28-3.23); this risk was higher for false-negatives (HR = 8.79, 95%CI: 6.24-12.40) than for true interval cancer (HR = 2.26, 95%CI: 1.59-3.21). A family history of breast cancer was associated with true intervals (HR = 2.11, 95%CI: 1.60-2.78), previous benign biopsy with a false-negatives (HR = 1.83, 95%CI: 1.23-2.71). High breast density was mainly associated with occult tumors (RRR = 4.92, 95%CI: 2.58-9.38), followed by true intervals (RRR = 1.67, 95%CI: 1.18-2.36) and false-negatives (RRR = 1.58, 95%CI: 1.00-2.49).<h4>Conclusion</h4>The role of women's characteristics differs among interval cancer subtypes. This information could be useful to improve effectiveness of breast cancer screening programmes and to better classify subgroups of women with different risks of developing cancer.Jordi BlanchMaria SalaJosefa IbáñezLaia DomingoBelén FernandezArantza OtegiTeresa BarataRaquel ZubizarretaJoana FerrerXavier CastellsMontserrat RuéDolores SalasINCA Study GroupPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 10, p e110207 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jordi Blanch Maria Sala Josefa Ibáñez Laia Domingo Belén Fernandez Arantza Otegi Teresa Barata Raquel Zubizarreta Joana Ferrer Xavier Castells Montserrat Rué Dolores Salas INCA Study Group Impact of risk factors on different interval cancer subtypes in a population-based breast cancer screening programme.
description	<h4>Background</h4>Interval cancers are primary breast cancers diagnosed in women after a negative screening test and before the next screening invitation. Our aim was to evaluate risk factors for interval cancer and their subtypes and to compare the risk factors identified with those associated with incident screen-detected cancers.<h4>Methods</h4>We analyzed data from 645,764 women participating in the Spanish breast cancer screening program from 2000-2006 and followed-up until 2009. A total of 5,309 screen-detected and 1,653 interval cancers were diagnosed. Among the latter, 1,012 could be classified on the basis of findings in screening and diagnostic mammograms, consisting of 489 true interval cancers (48.2%), 235 false-negatives (23.2%), 172 minimal-signs (17.2%) and 114 occult tumors (11.3%). Information on the screening protocol and women's characteristics were obtained from the screening program registry. Cause-specific Cox regression models were used to estimate the hazard ratios (HR) of risks factors for interval cancer and incident screen-detected cancer. A multinomial regression model, using screen-detected tumors as a reference group, was used to assess the effect of breast density and other factors on the occurrence of interval cancer subtypes.<h4>Results</h4>A previous false-positive was the main risk factor for interval cancer (HR = 2.71, 95%CI: 2.28-3.23); this risk was higher for false-negatives (HR = 8.79, 95%CI: 6.24-12.40) than for true interval cancer (HR = 2.26, 95%CI: 1.59-3.21). A family history of breast cancer was associated with true intervals (HR = 2.11, 95%CI: 1.60-2.78), previous benign biopsy with a false-negatives (HR = 1.83, 95%CI: 1.23-2.71). High breast density was mainly associated with occult tumors (RRR = 4.92, 95%CI: 2.58-9.38), followed by true intervals (RRR = 1.67, 95%CI: 1.18-2.36) and false-negatives (RRR = 1.58, 95%CI: 1.00-2.49).<h4>Conclusion</h4>The role of women's characteristics differs among interval cancer subtypes. This information could be useful to improve effectiveness of breast cancer screening programmes and to better classify subgroups of women with different risks of developing cancer.
format	article
author	Jordi Blanch Maria Sala Josefa Ibáñez Laia Domingo Belén Fernandez Arantza Otegi Teresa Barata Raquel Zubizarreta Joana Ferrer Xavier Castells Montserrat Rué Dolores Salas INCA Study Group
author_facet	Jordi Blanch Maria Sala Josefa Ibáñez Laia Domingo Belén Fernandez Arantza Otegi Teresa Barata Raquel Zubizarreta Joana Ferrer Xavier Castells Montserrat Rué Dolores Salas INCA Study Group
author_sort	Jordi Blanch
title	Impact of risk factors on different interval cancer subtypes in a population-based breast cancer screening programme.
title_short	Impact of risk factors on different interval cancer subtypes in a population-based breast cancer screening programme.
title_full	Impact of risk factors on different interval cancer subtypes in a population-based breast cancer screening programme.
title_fullStr	Impact of risk factors on different interval cancer subtypes in a population-based breast cancer screening programme.
title_full_unstemmed	Impact of risk factors on different interval cancer subtypes in a population-based breast cancer screening programme.
title_sort	impact of risk factors on different interval cancer subtypes in a population-based breast cancer screening programme.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/27b16eca5fad4e2386747d8678620049
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Impact of risk factors on different interval cancer subtypes in a population-based breast cancer screening programme.

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