A 1,000-Year-Old Antimicrobial Remedy with Antistaphylococcal Activity

ABSTRACT Plant-derived compounds and other natural substances are a rich potential source of compounds that kill or attenuate pathogens that are resistant to current antibiotics. Medieval societies used a range of these natural substances to treat conditions clearly recognizable to the modern eye as...

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Autores principales:	Freya Harrison, Aled E. L. Roberts, Rebecca Gabrilska, Kendra P. Rumbaugh, Christina Lee, Stephen P. Diggle
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2015
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/27b1a8e836224ae694662dd7a648d3da
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spelling	oai:doaj.org-article:27b1a8e836224ae694662dd7a648d3da2021-11-15T15:41:26ZA 1,000-Year-Old Antimicrobial Remedy with Antistaphylococcal Activity10.1128/mBio.01129-152150-7511https://doaj.org/article/27b1a8e836224ae694662dd7a648d3da2015-09-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01129-15https://doaj.org/toc/2150-7511ABSTRACT Plant-derived compounds and other natural substances are a rich potential source of compounds that kill or attenuate pathogens that are resistant to current antibiotics. Medieval societies used a range of these natural substances to treat conditions clearly recognizable to the modern eye as microbial infections, and there has been much debate over the likely efficacy of these treatments. Our interdisciplinary team, comprising researchers from both sciences and humanities, identified and reconstructed a potential remedy for Staphylococcus aureus infection from a 10th century Anglo-Saxon leechbook. The remedy repeatedly killed established S. aureus biofilms in an in vitro model of soft tissue infection and killed methicillin-resistant S. aureus (MRSA) in a mouse chronic wound model. While the remedy contained several ingredients that are individually known to have some antibacterial activity, full efficacy required the combined action of several ingredients, highlighting the scholarship of premodern doctors and the potential of ancient texts as a source of new antimicrobial agents. IMPORTANCE While the antibiotic potential of some materials used in historical medicine has been demonstrated, empirical tests of entire remedies are scarce. This is an important omission, because the efficacy of “ancientbiotics” could rely on the combined activity of their various ingredients. This would lead us to underestimate their efficacy and, by extension, the scholarship of premodern doctors. It could also help us to understand why some natural compounds that show antibacterial promise in the laboratory fail to yield positive results in clinical trials. We have reconstructed a 1,000-year-old remedy which kills the bacteria it was designed to treat and have shown that this activity relies on the combined activity of several antimicrobial ingredients. Our results highlight (i) the scholarship and rational methodology of premodern medical professionals and (ii) the untapped potential of premodern remedies for yielding novel therapeutics at a time when new antibiotics are desperately needed.Freya HarrisonAled E. L. RobertsRebecca GabrilskaKendra P. RumbaughChristina LeeStephen P. DiggleAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 6, Iss 4 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Freya Harrison Aled E. L. Roberts Rebecca Gabrilska Kendra P. Rumbaugh Christina Lee Stephen P. Diggle A 1,000-Year-Old Antimicrobial Remedy with Antistaphylococcal Activity
description	ABSTRACT Plant-derived compounds and other natural substances are a rich potential source of compounds that kill or attenuate pathogens that are resistant to current antibiotics. Medieval societies used a range of these natural substances to treat conditions clearly recognizable to the modern eye as microbial infections, and there has been much debate over the likely efficacy of these treatments. Our interdisciplinary team, comprising researchers from both sciences and humanities, identified and reconstructed a potential remedy for Staphylococcus aureus infection from a 10th century Anglo-Saxon leechbook. The remedy repeatedly killed established S. aureus biofilms in an in vitro model of soft tissue infection and killed methicillin-resistant S. aureus (MRSA) in a mouse chronic wound model. While the remedy contained several ingredients that are individually known to have some antibacterial activity, full efficacy required the combined action of several ingredients, highlighting the scholarship of premodern doctors and the potential of ancient texts as a source of new antimicrobial agents. IMPORTANCE While the antibiotic potential of some materials used in historical medicine has been demonstrated, empirical tests of entire remedies are scarce. This is an important omission, because the efficacy of “ancientbiotics” could rely on the combined activity of their various ingredients. This would lead us to underestimate their efficacy and, by extension, the scholarship of premodern doctors. It could also help us to understand why some natural compounds that show antibacterial promise in the laboratory fail to yield positive results in clinical trials. We have reconstructed a 1,000-year-old remedy which kills the bacteria it was designed to treat and have shown that this activity relies on the combined activity of several antimicrobial ingredients. Our results highlight (i) the scholarship and rational methodology of premodern medical professionals and (ii) the untapped potential of premodern remedies for yielding novel therapeutics at a time when new antibiotics are desperately needed.
format	article
author	Freya Harrison Aled E. L. Roberts Rebecca Gabrilska Kendra P. Rumbaugh Christina Lee Stephen P. Diggle
author_facet	Freya Harrison Aled E. L. Roberts Rebecca Gabrilska Kendra P. Rumbaugh Christina Lee Stephen P. Diggle
author_sort	Freya Harrison
title	A 1,000-Year-Old Antimicrobial Remedy with Antistaphylococcal Activity
title_short	A 1,000-Year-Old Antimicrobial Remedy with Antistaphylococcal Activity
title_full	A 1,000-Year-Old Antimicrobial Remedy with Antistaphylococcal Activity
title_fullStr	A 1,000-Year-Old Antimicrobial Remedy with Antistaphylococcal Activity
title_full_unstemmed	A 1,000-Year-Old Antimicrobial Remedy with Antistaphylococcal Activity
title_sort	1,000-year-old antimicrobial remedy with antistaphylococcal activity
publisher	American Society for Microbiology
publishDate	2015
url	https://doaj.org/article/27b1a8e836224ae694662dd7a648d3da
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A 1,000-Year-Old Antimicrobial Remedy with Antistaphylococcal Activity

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