Effect of zinc oxide nanoparticles on anxiety-related behaviors in male rats

The objective of this study was to investigate the influences of zinc oxide nanoparticles (ZONPs) on the anxiety-related behaviors of male albino rats. Because of the sexual differences found in the anxiety related disorders, thirty-six male albino rats 40-days old weighed from 130 to 150 g and divi...

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Autores principales:	Ahmed Mohammed, Hayam Hamdy, Ghada Abdelrady, Mahmoud Seliman, Usama Mahmoud
Formato:	article
Lenguaje:	EN
Publicado:	South Valley University 2020
Materias:	rats anxiety zinc oxide behavior brain Agriculture S Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/27b1d353f65f4b6292b0e2301ad8a871
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spelling	oai:doaj.org-article:27b1d353f65f4b6292b0e2301ad8a8712021-12-02T08:24:09ZEffect of zinc oxide nanoparticles on anxiety-related behaviors in male rats10.21608/SVU.2020.22360.10412535-18262535-1877https://doaj.org/article/27b1d353f65f4b6292b0e2301ad8a8712020-05-01T00:00:00Zhttps://svu.journals.ekb.eg/article_87110.htmlhttps://doaj.org/toc/2535-1826https://doaj.org/toc/2535-1877The objective of this study was to investigate the influences of zinc oxide nanoparticles (ZONPs) on the anxiety-related behaviors of male albino rats. Because of the sexual differences found in the anxiety related disorders, thirty-six male albino rats 40-days old weighed from 130 to 150 g and divided into three groups; group I served as a control, groups II and III were subjected to daily intraperitoneal injection of ZONPs (30 mg/kg or 60 mg/kg, respectively) for 5 days sequentially. Each treatment contained four replicates of 3 rats each. Eight rats per treatment (i.e.2 rats/replicate) were randomly taken and marked with green livestock spray for behavioral observation and anxiety testing on same day of injection. Elevated plus maize, open field, forced swimming, tail suspension tests were used for anxiety testing. Afterwards, the rats were sacrificed, and the histopathological evaluation of brain tissue was done. The results showed that the intraperitoneal injection of ZONPs reduced the standing behavior, climbing time of the forced swimming test, and increased the sleeping behavior, immobility time of the forced swimming test and agitation and immobility time of the tail suspension test (P < 0.05); while the ZONPs had no effects on alert activities, open field test, and elevated plus maize test (P > 0.05) in ZONPs injected groups. In addition, ZONPs induced necrosis of the nerve cells in cerebral cortex and the Purkinje cells in cerebellum.Ahmed Mohammed Hayam HamdyGhada AbdelradyMahmoud SelimanUsama MahmoudSouth Valley Universityarticleratsanxietyzinc oxidebehaviorbrainAgricultureSVeterinary medicineSF600-1100ENSVU-International Journal of Veterinary Sciences, Vol 3, Iss 1, Pp 123-132 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	rats anxiety zinc oxide behavior brain Agriculture S Veterinary medicine SF600-1100
spellingShingle	rats anxiety zinc oxide behavior brain Agriculture S Veterinary medicine SF600-1100 Ahmed Mohammed Hayam Hamdy Ghada Abdelrady Mahmoud Seliman Usama Mahmoud Effect of zinc oxide nanoparticles on anxiety-related behaviors in male rats
description	The objective of this study was to investigate the influences of zinc oxide nanoparticles (ZONPs) on the anxiety-related behaviors of male albino rats. Because of the sexual differences found in the anxiety related disorders, thirty-six male albino rats 40-days old weighed from 130 to 150 g and divided into three groups; group I served as a control, groups II and III were subjected to daily intraperitoneal injection of ZONPs (30 mg/kg or 60 mg/kg, respectively) for 5 days sequentially. Each treatment contained four replicates of 3 rats each. Eight rats per treatment (i.e.2 rats/replicate) were randomly taken and marked with green livestock spray for behavioral observation and anxiety testing on same day of injection. Elevated plus maize, open field, forced swimming, tail suspension tests were used for anxiety testing. Afterwards, the rats were sacrificed, and the histopathological evaluation of brain tissue was done. The results showed that the intraperitoneal injection of ZONPs reduced the standing behavior, climbing time of the forced swimming test, and increased the sleeping behavior, immobility time of the forced swimming test and agitation and immobility time of the tail suspension test (P < 0.05); while the ZONPs had no effects on alert activities, open field test, and elevated plus maize test (P > 0.05) in ZONPs injected groups. In addition, ZONPs induced necrosis of the nerve cells in cerebral cortex and the Purkinje cells in cerebellum.
format	article
author	Ahmed Mohammed Hayam Hamdy Ghada Abdelrady Mahmoud Seliman Usama Mahmoud
author_facet	Ahmed Mohammed Hayam Hamdy Ghada Abdelrady Mahmoud Seliman Usama Mahmoud
author_sort	Ahmed Mohammed
title	Effect of zinc oxide nanoparticles on anxiety-related behaviors in male rats
title_short	Effect of zinc oxide nanoparticles on anxiety-related behaviors in male rats
title_full	Effect of zinc oxide nanoparticles on anxiety-related behaviors in male rats
title_fullStr	Effect of zinc oxide nanoparticles on anxiety-related behaviors in male rats
title_full_unstemmed	Effect of zinc oxide nanoparticles on anxiety-related behaviors in male rats
title_sort	effect of zinc oxide nanoparticles on anxiety-related behaviors in male rats
publisher	South Valley University
publishDate	2020
url	https://doaj.org/article/27b1d353f65f4b6292b0e2301ad8a871
work_keys_str_mv	AT ahmedmohammed effectofzincoxidenanoparticlesonanxietyrelatedbehaviorsinmalerats AT hayamhamdy effectofzincoxidenanoparticlesonanxietyrelatedbehaviorsinmalerats AT ghadaabdelrady effectofzincoxidenanoparticlesonanxietyrelatedbehaviorsinmalerats AT mahmoudseliman effectofzincoxidenanoparticlesonanxietyrelatedbehaviorsinmalerats AT usamamahmoud effectofzincoxidenanoparticlesonanxietyrelatedbehaviorsinmalerats
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Effect of zinc oxide nanoparticles on anxiety-related behaviors in male rats

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