Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ

The repressive states of peroxisome proliferator-activated receptor γ (PPARγ) are ill-defined, despite nuclear receptors being a major drug target. Here authors demonstrate multiple structurally distinct repressive states, providing a structural rationale for ligand bias in a nuclear receptor.

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Autores principales:	Zahra Heidari, Ian M. Chrisman, Michelle D. Nemetchek, Scott J. Novick, Anne-Laure Blayo, Trey Patton, Desiree E. Mendes, Philippe Diaz, Theodore M. Kamenecka, Patrick R. Griffin, Travis S. Hughes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/27b2fda7dc814baabc2b2a797db6f945
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spelling	oai:doaj.org-article:27b2fda7dc814baabc2b2a797db6f9452021-12-02T17:32:39ZDefinition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ10.1038/s41467-019-13768-02041-1723https://doaj.org/article/27b2fda7dc814baabc2b2a797db6f9452019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13768-0https://doaj.org/toc/2041-1723The repressive states of peroxisome proliferator-activated receptor γ (PPARγ) are ill-defined, despite nuclear receptors being a major drug target. Here authors demonstrate multiple structurally distinct repressive states, providing a structural rationale for ligand bias in a nuclear receptor.Zahra HeidariIan M. ChrismanMichelle D. NemetchekScott J. NovickAnne-Laure BlayoTrey PattonDesiree E. MendesPhilippe DiazTheodore M. KameneckaPatrick R. GriffinTravis S. HughesNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zahra Heidari Ian M. Chrisman Michelle D. Nemetchek Scott J. Novick Anne-Laure Blayo Trey Patton Desiree E. Mendes Philippe Diaz Theodore M. Kamenecka Patrick R. Griffin Travis S. Hughes Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ
description	The repressive states of peroxisome proliferator-activated receptor γ (PPARγ) are ill-defined, despite nuclear receptors being a major drug target. Here authors demonstrate multiple structurally distinct repressive states, providing a structural rationale for ligand bias in a nuclear receptor.
format	article
author	Zahra Heidari Ian M. Chrisman Michelle D. Nemetchek Scott J. Novick Anne-Laure Blayo Trey Patton Desiree E. Mendes Philippe Diaz Theodore M. Kamenecka Patrick R. Griffin Travis S. Hughes
author_facet	Zahra Heidari Ian M. Chrisman Michelle D. Nemetchek Scott J. Novick Anne-Laure Blayo Trey Patton Desiree E. Mendes Philippe Diaz Theodore M. Kamenecka Patrick R. Griffin Travis S. Hughes
author_sort	Zahra Heidari
title	Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ
title_short	Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ
title_full	Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ
title_fullStr	Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ
title_full_unstemmed	Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ
title_sort	definition of functionally and structurally distinct repressive states in the nuclear receptor pparγ
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/27b2fda7dc814baabc2b2a797db6f945
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Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ

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