Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus

Proton pump inhibitors (PPIs) reduce gastric acid secretion and modulate gut microbiota composition. Here Llorente et al. show that PPIs induce bacterial overgrowth of enterococci, which, in turn, exacerbate ethanol-induced liver disease both in mice and humans.

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Autores principales:	Cristina Llorente, Peter Jepsen, Tatsuo Inamine, Lirui Wang, Sena Bluemel, Hui J. Wang, Rohit Loomba, Jasmohan S. Bajaj, Mitchell L. Schubert, Masoumeh Sikaroodi, Patrick M. Gillevet, Jun Xu, Tatiana Kisseleva, Samuel B. Ho, Jessica DePew, Xin Du, Henrik T. Sørensen, Hendrik Vilstrup, Karen E. Nelson, David A. Brenner, Derrick E. Fouts, Bernd Schnabl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/27b348ac046b489ebb905be4e8fb371a
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spelling	oai:doaj.org-article:27b348ac046b489ebb905be4e8fb371a2021-12-02T15:38:41ZGastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus10.1038/s41467-017-00796-x2041-1723https://doaj.org/article/27b348ac046b489ebb905be4e8fb371a2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00796-xhttps://doaj.org/toc/2041-1723Proton pump inhibitors (PPIs) reduce gastric acid secretion and modulate gut microbiota composition. Here Llorente et al. show that PPIs induce bacterial overgrowth of enterococci, which, in turn, exacerbate ethanol-induced liver disease both in mice and humans.Cristina LlorentePeter JepsenTatsuo InamineLirui WangSena BluemelHui J. WangRohit LoombaJasmohan S. BajajMitchell L. SchubertMasoumeh SikaroodiPatrick M. GillevetJun XuTatiana KisselevaSamuel B. HoJessica DePewXin DuHenrik T. SørensenHendrik VilstrupKaren E. NelsonDavid A. BrennerDerrick E. FoutsBernd SchnablNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Cristina Llorente Peter Jepsen Tatsuo Inamine Lirui Wang Sena Bluemel Hui J. Wang Rohit Loomba Jasmohan S. Bajaj Mitchell L. Schubert Masoumeh Sikaroodi Patrick M. Gillevet Jun Xu Tatiana Kisseleva Samuel B. Ho Jessica DePew Xin Du Henrik T. Sørensen Hendrik Vilstrup Karen E. Nelson David A. Brenner Derrick E. Fouts Bernd Schnabl Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus
description	Proton pump inhibitors (PPIs) reduce gastric acid secretion and modulate gut microbiota composition. Here Llorente et al. show that PPIs induce bacterial overgrowth of enterococci, which, in turn, exacerbate ethanol-induced liver disease both in mice and humans.
format	article
author	Cristina Llorente Peter Jepsen Tatsuo Inamine Lirui Wang Sena Bluemel Hui J. Wang Rohit Loomba Jasmohan S. Bajaj Mitchell L. Schubert Masoumeh Sikaroodi Patrick M. Gillevet Jun Xu Tatiana Kisseleva Samuel B. Ho Jessica DePew Xin Du Henrik T. Sørensen Hendrik Vilstrup Karen E. Nelson David A. Brenner Derrick E. Fouts Bernd Schnabl
author_facet	Cristina Llorente Peter Jepsen Tatsuo Inamine Lirui Wang Sena Bluemel Hui J. Wang Rohit Loomba Jasmohan S. Bajaj Mitchell L. Schubert Masoumeh Sikaroodi Patrick M. Gillevet Jun Xu Tatiana Kisseleva Samuel B. Ho Jessica DePew Xin Du Henrik T. Sørensen Hendrik Vilstrup Karen E. Nelson David A. Brenner Derrick E. Fouts Bernd Schnabl
author_sort	Cristina Llorente
title	Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus
title_short	Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus
title_full	Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus
title_fullStr	Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus
title_full_unstemmed	Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus
title_sort	gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal enterococcus
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/27b348ac046b489ebb905be4e8fb371a
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Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus

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